Manteia

ENSMUSG00000044199

Mus musculus

Features

Gene ID:	ENSMUSG00000044199

Biological name :	S1pr4

Synonyms :	Q9Z0L1 / S1pr4 / Sphingosine 1-phosphate receptor 4

Possible biological names infered from orthology :	O95977

Species:	Mus musculus

Chr. number:	10
Strand:	-1
Band:	C1
Gene start:	81497747
Gene end:	81500132

Corresponding Affymetrix probe sets:	10371217 (MoGene1.0st) 1451024_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000050412 NCBI entrez gene - 13611 See in Manteia. MGI - MGI:1333809 RefSeq - NM_010102 RefSeq Peptide - NP_034232 swissprot - Q9Z0L1 Ensembl - ENSMUSG00000044199

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
S1pr5 / Q91X56 / Sphingosine 1-phosphate receptor 5 / Q9H228*	ENSMUSG00000045087	38
S1pr1 / O08530 / Sphingosine 1-phosphate receptor 1 / P21453*	ENSMUSG00000045092	35
S1pr3 / Q9Z0U9 / Sphingosine 1-phosphate receptor 3 / Q99500*	ENSMUSG00000067586	35
S1pr2 / P52592 / Sphingosine 1-phosphate receptor 2 / O95136*	ENSMUSG00000043895	32
Lpar1 / P61793 / Lysophosphatidic acid receptor 1 / Q92633*	ENSMUSG00000038668	28
Lpar2 / lysophosphatidic acid receptor 2 / Q9HBW0*	ENSMUSG00000031861	28
Lpar3 / Q9EQ31 / Lysophosphatidic acid receptor 3 / Q9UBY5*	ENSMUSG00000036832	25
Cnr1 / P47746 / Mus musculus cannabinoid receptor 1 (brain) (Cnr1), transcript variant 2, mRNA. / P21554* / cannabinoid receptor 1*	ENSMUSG00000044288	22
Gpr3 / P35413 / G-protein coupled receptor 3 / P46089*	ENSMUSG00000049649	22
Gpr12 / P35412 / G-protein coupled receptor 12 / P47775*	ENSMUSG00000041468	21
Gpr6 / Q6YNI2 / G-protein coupled receptor 6 / P46095*	ENSMUSG00000046922	21
Cnr2 / P47936 / Cannabinoid receptor 2 / P34972*	ENSMUSG00000062585	20

Protein motifs (from Interpro)

Interpro ID	Name
IPR000276	G protein-coupled receptor, rhodopsin-like
IPR004061	Sphingosine 1-phosphate receptor
IPR004064	EDG-6 sphingosine 1-phosphate receptor
IPR017452	GPCR, rhodopsin-like, 7TM

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0003376	sphingosine-1-phosphate signaling pathway	IEA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	IDA
cellular_component	GO:0005739	mitochondrion	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005887	integral component of plasma membrane	TAS
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0004930	G-protein coupled receptor activity	TAS
molecular_function	GO:0038036	sphingosine-1-phosphate receptor activity	IEA

Pathways (from Reactome)

Pathway description

G alpha (i) signalling events

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000228	abnormal thrombopoiesis	"abnormal development of the non-nucleated cells of the blood (platelets, thrombocytes) involved in blood coagulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tet2^tm1.1Mjxu/Tet2⁺ Genetic Background: involves: 129 * C57BL/6
MP:0002417	abnormal megakaryocyte morphology/development	"anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tet2^tm1.1Mjxu/Tet2⁺ Genetic Background: involves: 129 * C57BL/6
MP:0009142	decreased prepulse inhibition	"decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Icam1^tm1Bay/Icam1^tm1Bay,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Icam1^tm1Bay/Icam1^tm1Bay,Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr