ENSMUSG00000043895


Mus musculus

Features
Gene ID: ENSMUSG00000043895
  
Biological name :S1pr2
  
Synonyms : P52592 / S1pr2 / Sphingosine 1-phosphate receptor 2
  
Possible biological names infered from orthology : O95136
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A3
Gene start: 20962361
Gene end: 20976781
  
Corresponding Affymetrix probe sets: 10591412 (MoGene1.0st)   1428176_at (Mouse Genome 430 2.0 Array)   1447224_at (Mouse Genome 430 2.0 Array)   1447880_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000150113
Ensembl peptide - ENSMUSP00000053394
NCBI entrez gene - 14739     See in Manteia.
MGI - MGI:99569
RefSeq - NM_010333
RefSeq - XM_006510019
RefSeq Peptide - NP_034463
swissprot - A0A1L1ST05
swissprot - P52592
Ensembl - ENSMUSG00000043895
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 s1pr2ENSDARG00000036548Danio rerio
 S1PR2ENSG00000267534Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
S1pr1 / O08530 / Sphingosine 1-phosphate receptor 1 / P21453*ENSMUSG0000004509248
S1pr5 / Q91X56 / Sphingosine 1-phosphate receptor 5 / Q9H228*ENSMUSG0000004508745
S1pr3 / Q9Z0U9 / Sphingosine 1-phosphate receptor 3 / Q99500*ENSMUSG0000006758642
S1pr4 / Q9Z0L1 / Sphingosine 1-phosphate receptor 4 / O95977*ENSMUSG0000004419935
Lpar2 / lysophosphatidic acid receptor 2 / Q9HBW0*ENSMUSG0000003186131
Lpar1 / P61793 / Lysophosphatidic acid receptor 1 / Q92633*ENSMUSG0000003866829
Lpar3 / Q9EQ31 / Lysophosphatidic acid receptor 3 / Q9UBY5*ENSMUSG0000003683229
Gpr6 / Q6YNI2 / G-protein coupled receptor 6 / P46095*ENSMUSG0000004692226
Cnr1 / P47746 / Mus musculus cannabinoid receptor 1 (brain) (Cnr1), transcript variant 2, mRNA. / P21554* / cannabinoid receptor 1*ENSMUSG0000004428825
Gpr3 / P35413 / G-protein coupled receptor 3 / P46089*ENSMUSG0000004964924
Gpr12 / P35412 / G-protein coupled receptor 12 / P47775*ENSMUSG0000004146823
Cnr2 / P47936 / Cannabinoid receptor 2 / P34972*ENSMUSG0000006258521


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR004061  Sphingosine 1-phosphate receptor
 IPR004063  EDG-5 sphingosine 1-phosphate receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003376 sphingosine-1-phosphate signaling pathway ISO
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IMP
 biological_processGO:0031532 actin cytoskeleton reorganization ISO
 biological_processGO:0046847 filopodium assembly ISO
 biological_processGO:0090394 negative regulation of excitatory postsynaptic potential IMP
 biological_processGO:1903142 positive regulation of establishment of endothelial barrier ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005178 integrin binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0038036 sphingosine-1-phosphate receptor activity ISO


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Lysosphingolipid and LPA receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000034 abnormal vestibule morphology "malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)

 MP:0000048 abnormal stria vascularis "anomalous structure of the layer of highly vascularized pigmented granular cells on the outer wall of the cochlear duct" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Akr1b3tm1Tona/Akr1b3tm1Tona
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Akr1b3tm1Tona/Akr1b3tm1Tona
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Akr1b3tm1Tona/Akr1b3tm1Tona
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Akr1b3tm1Tona/Akr1b3tm1Tona
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Akr1b3tm1Tona/Akr1b3tm1Tona
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Akr1b3tm1Tona/Akr1b3tm1Tona
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fgf14tm1Dor/Fgf14tm1Dor
Genetic Background: B6.129S6-Fgf14tm1Dor

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: 129S5/SvEvBrd-S1pr2tm1Ajml

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf14tm1Dor/Fgf14tm1Dor
Genetic Background: B6.129S6-Fgf14tm1Dor

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)

Allelic Composition: S1pr2tm1Ytak/S1pr2tm1Ytak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)

Allelic Composition: S1pr2tm1.1Toka/S1pr2tm1.1Toka
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fgf14tm1Dor/Fgf14tm1Dor
Genetic Background: B6.129S6-Fgf14tm1Dor

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf14tm1Dor/Fgf14tm1Dor
Genetic Background: B6.129S6-Fgf14tm1Dor

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fgf14tm1Dor/Fgf14tm1Dor
Genetic Background: B6.129S6-Fgf14tm1Dor

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: S1pr2tm1Ytak/S1pr2tm1Ytak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003143 enlarged otoliths "increased average size of the crystalline calciferous particles adhering to the otolithic membrane" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:67072]
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Allelic Composition: S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003144 reduced number of otoliths "decreased average number of the crystalline calciferous particles adhering to the otolithic membrane" [J:30611, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)

 MP:0003149 abnormal tectorial membrane morphology "malformation, malfunction or absence of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: S1pr2tm1Ytak/S1pr2tm1Ytak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: S1pr2tm1Ytak/S1pr2tm1Ytak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004244 abnormal spontaneous abortion rate "change in frequency of a natural or accidental termination of a pregnancy at a stage where the embryo or the fetus is incapable of surviving independently of the mother" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004305 abnormal Rosenthal canal morphology "any structural abnormality in the winding tube of the bony labyrinth that makes two and a half turns about the modiolus of the cochlea; it is divided incompletely into two compartments by a winding shelf of bone, the bony spiral lamina" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)

 MP:0004324 vestibular hair cell degeneration "degeneration or loss of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0004329 saccular degeneration "degeneration or loss of the smaller of the two sacs in the vestibule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)

 MP:0004331 saccular macula degeneration "degeneration or loss of the oval neuroepithelial sensory receptor in the anterior wall of the saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0004334 utricular macular degeneration "degeneration or loss of the neuroepithelial sensory receptor in the inferolateral wall of the utricle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004364 thin stria vascularis "reduced thickness of the stratified, secretory epithelium which lines the upper part of the cochlear spiral ligament and maintains potassium ion homeostasis in the endolymph" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)

 MP:0004365 abnormal strial basal cells "any structural abnormality in the polarized cells which are juxtaposed to fibrocytes in the underlying spiral ligament" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004366 abnormal strial marginal cells "any structural abnormality in the polarized columnar cells of epithelial origin which cover the lateral surface of the cochlear duct, secrete potassium ions and form a continuous sheet in contact with the endolymph; marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004367 abnormal strial intermediate cells "any structural abnormality in the melanocytes known to migrate from the neural crest during ontogeny to become located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004368 abnormal stria vascularis vasculature "any structural anomaly of the blood vessels supplying the stria vascularis in the cochlea of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)

 MP:0004427 abnormal vestibular labyrinth "any structural abnormality in the portion of the membranous labyrinth concerned with the sense of equilibration (vs. the cochlear labyrinth, which is concerned with the sense of hearing) and innervated by the vestibular nerve; it is located within the semicircular canals and vestibule of the bony labyrinth, and consists of the utricle, saccule, and the semicircular, utriculosaccular, and endolymphatic ducts " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004465 degeneration of supporting cells "degeneration or loss of the highly differentiated epithelial cells with distinctive morphological features that surround all hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0004518 absent vestibular hair cell stereocilia "complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on vestibular hair cells in a staircase-like pattern" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0004737 absent distortion product otoacoustic emissions "failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004742 abnormal vestibular system physiology "any functional anomaly of the sensory system responsible for the sense of head position and movement of the body through space; such anomalies may include impaired balance, dizziness, poor regulation of postural muscle tone and inability to detect quick movements of the head " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)

 MP:0004897 otosclerosis "formation of spongy bone in the bony labyrinth of the ear, especially adjacent to the footplate of the stapes; it may cause bony ankylosis of the stapes, resulting in conductive hearing loss; cochlear otosclerosis results in sensorineural hearing loss" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005601 increased angiogenesis "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: S1pr2tm1Ytak/S1pr2tm1Ytak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006023 detached Reissner membrane "partial or complete loss of connection between the membrane and the vestibular wall" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Akr1b3tm1Tona/Akr1b3tm1Tona
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Allelic Composition: S1pr3tm1Jch/S1pr3+,S1pr2tm1Jch/S1pr2tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008308 small scala media "reduced size of the spirally arranged membranous tube suspended within the cochlea, lying between and separating the scala vestibuli and scala tympani" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008483 increased spleen germinal center size "greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008783 decreased B cell apoptosis "reduction in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Ytak/S1pr2tm1Ytak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: S1pr2tm1Ytak/S1pr2tm1Ytak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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