ENSMUSG00000067586


Mus musculus

Features
Gene ID: ENSMUSG00000067586
  
Biological name :S1pr3
  
Synonyms : Q9Z0U9 / S1pr3 / Sphingosine 1-phosphate receptor 3
  
Possible biological names infered from orthology : Q99500
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A5
Gene start: 51408639
Gene end: 51422797
  
Corresponding Affymetrix probe sets: 10405179 (MoGene1.0st)   1437173_at (Mouse Genome 430 2.0 Array)   1438658_a_at (Mouse Genome 430 2.0 Array)   1460661_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000085293
NCBI entrez gene - 13610     See in Manteia.
MGI - MGI:1339365
RefSeq - NM_010101
RefSeq Peptide - NP_034231
swissprot - Q9Z0U9
Ensembl - ENSMUSG00000067586
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 s1pr3aENSDARG00000042470Danio rerio
 S1PR3ENSG00000213694Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
S1pr1 / O08530 / Sphingosine 1-phosphate receptor 1 / P21453*ENSMUSG0000004509250
S1pr5 / Q91X56 / Sphingosine 1-phosphate receptor 5 / Q9H228*ENSMUSG0000004508741
S1pr2 / P52592 / Sphingosine 1-phosphate receptor 2 / O95136*ENSMUSG0000004389539
S1pr4 / Q9Z0L1 / Sphingosine 1-phosphate receptor 4 / O95977*ENSMUSG0000004419936
Lpar1 / P61793 / Lysophosphatidic acid receptor 1 / Q92633*ENSMUSG0000003866831
Lpar2 / lysophosphatidic acid receptor 2 / Q9HBW0*ENSMUSG0000003186129
Lpar3 / Q9EQ31 / Lysophosphatidic acid receptor 3 / Q9UBY5*ENSMUSG0000003683229
Cnr1 / P47746 / Mus musculus cannabinoid receptor 1 (brain) (Cnr1), transcript variant 2, mRNA. / P21554* / cannabinoid receptor 1*ENSMUSG0000004428824
Gpr6 / Q6YNI2 / G-protein coupled receptor 6 / P46095*ENSMUSG0000004692223
Gpr12 / P35412 / G-protein coupled receptor 12 / P47775*ENSMUSG0000004146822
Gpr3 / P35413 / G-protein coupled receptor 3 / P46089*ENSMUSG0000004964921
Cnr2 / P47936 / Cannabinoid receptor 2 / P34972*ENSMUSG0000006258519


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR004061  Sphingosine 1-phosphate receptor
 IPR004062  EDG-3 sphingosine 1-phosphate receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production IMP
 biological_processGO:0003376 sphingosine-1-phosphate signaling pathway IEA
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0032651 regulation of interleukin-1 beta production IMP
 biological_processGO:1903141 negative regulation of establishment of endothelial barrier IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0038036 sphingosine-1-phosphate receptor activity IEA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Lysosphingolipid and LPA receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000034 abnormal vestibule morphology "malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Akr1b3tm1Tona/Akr1b3tm1Tona
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Akr1b3tm1Tona/Akr1b3tm1Tona
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Akr1b3tm1Tona/Akr1b3tm1Tona
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Akr1b3tm1Tona/Akr1b3tm1Tona
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Akr1b3tm1Tona/Akr1b3tm1Tona
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf14tm1Dor/Fgf14tm1Dor
Genetic Background: B6.129S6-Fgf14tm1Dor

Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr,Vcam1tm1Dmil/Vcam1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002273 abnormal alveolar epithelial cell morphology "any structural anomaly of the cells lining the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf14tm1Dor/Fgf14tm1Dor
Genetic Background: B6.129S6-Fgf14tm1Dor

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0004244 abnormal spontaneous abortion rate "change in frequency of a natural or accidental termination of a pregnancy at a stage where the embryo or the fetus is incapable of surviving independently of the mother" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004324 vestibular hair cell degeneration "degeneration or loss of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0004331 saccular macula degeneration "degeneration or loss of the oval neuroepithelial sensory receptor in the anterior wall of the saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0004334 utricular macular degeneration "degeneration or loss of the neuroepithelial sensory receptor in the inferolateral wall of the utricle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0004465 degeneration of supporting cells "degeneration or loss of the highly differentiated epithelial cells with distinctive morphological features that surround all hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0004518 absent vestibular hair cell stereocilia "complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on vestibular hair cells in a staircase-like pattern" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0004742 abnormal vestibular system physiology "any functional anomaly of the sensory system responsible for the sense of head position and movement of the body through space; such anomalies may include impaired balance, dizziness, poor regulation of postural muscle tone and inability to detect quick movements of the head " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf14tm1Dor/Fgf14tm1Dor
Genetic Background: B6.129S6-Fgf14tm1Dor

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Allelic Composition: S1pr3tm1Jch/S1pr3+,S1pr2tm1Jch/S1pr2tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0008466 enlarged mesenteric lymph nodes "increased size of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: CrygcM1Sbao/Crygc+
Genetic Background: involves: BALB/cJ * ICR

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: CrygcM1Sbao/Crygc+
Genetic Background: involves: BALB/cJ * ICR

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: CrygcM1Sbao/Crygc+
Genetic Background: involves: BALB/cJ * ICR

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: CrygcM1Sbao/Crygc+
Genetic Background: involves: BALB/cJ * ICR

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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