ENSMUSG00000044288


Mus musculus

Features
Gene ID: ENSMUSG00000044288
  
Biological name :Cnr1
  
Synonyms : Cnr1 / Mus musculus cannabinoid receptor 1 (brain) (Cnr1), transcript variant 2, mRNA. / P47746
  
Possible biological names infered from orthology : cannabinoid receptor 1 / P21554
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A5
Gene start: 33924593
Gene end: 33948831
  
Corresponding Affymetrix probe sets: 10503902 (MoGene1.0st)   1419425_at (Mouse Genome 430 2.0 Array)   1434172_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000055797
Ensembl peptide - ENSMUSP00000081787
NCBI entrez gene - 12801     See in Manteia.
MGI - MGI:104615
RefSeq - XM_017319939
RefSeq - NM_001355020
RefSeq - NM_007726
RefSeq - XM_006537592
RefSeq - XM_006537593
RefSeq - XM_006537594
RefSeq - XM_006537595
RefSeq - XM_006537591
RefSeq Peptide - NP_001341950
RefSeq Peptide - NP_031752
RefSeq Peptide - NP_001341949
swissprot - P47746
Ensembl - ENSMUSG00000044288
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnr1ENSDARG00000009020Danio rerio
 CNR1ENSGALG00000037511Gallus gallus
 CNR1ENSG00000118432Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cnr2 / P47936 / Cannabinoid receptor 2 / P34972*ENSMUSG0000006258534
S1pr1 / O08530 / Sphingosine 1-phosphate receptor 1 / P21453*ENSMUSG0000004509220
S1pr2 / P52592 / Sphingosine 1-phosphate receptor 2 / O95136*ENSMUSG0000004389519
S1pr3 / Q9Z0U9 / Sphingosine 1-phosphate receptor 3 / Q99500*ENSMUSG0000006758619
Lpar1 / P61793 / Lysophosphatidic acid receptor 1 / Q92633*ENSMUSG0000003866819
S1pr4 / Q9Z0L1 / Sphingosine 1-phosphate receptor 4 / O95977*ENSMUSG0000004419918
S1pr5 / Q91X56 / Sphingosine 1-phosphate receptor 5 / Q9H228*ENSMUSG0000004508718
Gpr6 / Q6YNI2 / G-protein coupled receptor 6 / P46095*ENSMUSG0000004692217
Gpr12 / P35412 / G-protein coupled receptor 12 / P47775*ENSMUSG0000004146817
Lpar2 / lysophosphatidic acid receptor 2 / Q9HBW0*ENSMUSG0000003186117
Lpar3 / Q9EQ31 / Lysophosphatidic acid receptor 3 / Q9UBY5*ENSMUSG0000003683216
Gpr3 / P35413 / G-protein coupled receptor 3 / P46089*ENSMUSG0000004964916


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000810  Cannabinoid receptor type 1
 IPR002230  Cannabinoid receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002866 positive regulation of acute inflammatory response to antigenic stimulus IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007413 axonal fasciculation IMP
 biological_processGO:0007568 aging IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0019216 regulation of lipid metabolic process IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0031622 positive regulation of fever generation IEA
 biological_processGO:0031999 negative regulation of fatty acid beta-oxidation IEA
 biological_processGO:0032228 regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0033004 negative regulation of mast cell activation IEA
 biological_processGO:0033602 negative regulation of dopamine secretion IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0038171 cannabinoid signaling pathway IMP
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042593 glucose homeostasis IPI
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043271 negative regulation of ion transport IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045759 negative regulation of action potential IEA
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0050796 regulation of insulin secretion IEA
 biological_processGO:0051001 negative regulation of nitric-oxide synthase activity IEA
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0060135 maternal process involved in female pregnancy IEA
 biological_processGO:0060259 regulation of feeding behavior IEA
 biological_processGO:0060405 regulation of penile erection IEA
 biological_processGO:0099553 trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IMP
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030426 growth cone IDA
 cellular_componentGO:0042734 presynaptic membrane IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004949 cannabinoid receptor activity ISO
 molecular_functionGO:0008144 drug binding IEA


Pathways (from Reactome)
Pathway description
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Wlstm1.1Whsu/Wlstm1.1Whsu,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Cnr1tm1.1Kpm/Cnr1tm1.1Kpm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Cnr1tm1Map/Cnr1tm1Map,Tg(HD82Gln)81Gschi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * CD-1

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001353 increased aggression to other mice "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Cnr1tm2Ltz/Cnr1tm2Ltz
Genetic Background: B6.Cg-Cnr1tm2Ltz

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: a/a,Myo5ad/Myo5a+,Oca2p/Oca2+,Tyrp1B-lt/Tyrp1+
Genetic Background: involves: C58 * CT/Ch

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cnr1tm1Map/Cnr1tm1Map,Tg(HD82Gln)81Gschi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * CD-1

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Nfatc1tm3Glm/Nfatc1tm3Glm,Sh3bp2tm1Bjro/Sh3bp2tm1Bjro,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Cnr1tm2Ltz/Cnr1tm2Ltz
Genetic Background: B6.Cg-Cnr1tm2Ltz

Allelic Composition: Cnr1tm2Ltz/Cnr1tm2.1Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: B6.Cg-Cnr1tm2Ltz/Cnr1tm2.1Ltz

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Nfatc1tm3Glm/Nfatc1tm3Glm,Sh3bp2tm1Bjro/Sh3bp2tm1Bjro,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cnr1tm1Map/Cnr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001731 abnormal postnatal growth "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]
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Allelic Composition: Cnr1tm1Map/Cnr1tm1Map,Tg(HD82Gln)81Gschi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * CD-1

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: a/a,Myo5ad/Myo5a+,Oca2p/Oca2+,Tyrp1B-lt/Tyrp1+
Genetic Background: involves: C58 * CT/Ch

 MP:0001748 increased circulating adrenocorticotropin level "elevated concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Cnr1tm1.1Ltz/Cnr1tm1.1Ltz
Genetic Background: B6.129P2-Cnr1tm1.1Ltz

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: a/a,Myo5ad/Myo5a+,Oca2p/Oca2+,Tyrp1B-lt/Tyrp1+
Genetic Background: involves: C58 * CT/Ch

 MP:0001981 enhanced chemically-elicited antinociception "greater than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Inpp5dm2Btlr/Inpp5dm2Btlr
Genetic Background: C57BL/6J-Inpp5dm2Btlr

 MP:0001982 reduced chemically-elicited antinociception "less than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfatc1tm3Glm/Nfatc1tm3Glm,Sh3bp2tm1Bjro/Sh3bp2tm1Bjro,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: a/a,Myo5ad/Myo5a+,Oca2p/Oca2+,Tyrp1B-lt/Tyrp1+
Genetic Background: involves: C58 * CT/Ch

Allelic Composition: Cnr1tm1Map/Cnr1tm1Map,Tg(HD82Gln)81Gschi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * CD-1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cnr1tm2Ltz/Cnr1tm2.1Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: B6.Cg-Cnr1tm2Ltz/Cnr1tm2.1Ltz

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0002674 abnormal sperm motility "anomalies in the mobility of the spermatozoa" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Wlstm1.1Whsu/Wlstm1.1Whsu,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: a/a,Myo5ad/Myo5a+,Oca2p/Oca2+,Tyrp1B-lt/Tyrp1+
Genetic Background: involves: C58 * CT/Ch

 MP:0002798 abnormal active avoidance behavior "defects in the ability to escape a hostile environment to actively avoid the unpleasant or punishing stimuli ( e.g. shock) previously encountered in this environment" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0002822 catalepsy "a condition characterized by inactivity, lack of response to stimuli, and a tendency to maintain an immobile posture; the limbs tend to remain in whatever position they are placed (waxy rigidity); occurs with some psychoses, nervous system drug toxicity, and other conditions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: a/a,Myo5ad/Myo5a+,Oca2p/Oca2+,Tyrp1B-lt/Tyrp1+
Genetic Background: involves: C58 * CT/Ch

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Cxcr4tm1Tng/Cxcr4tm1Tng
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cnr1tm1.1Ltz/Cnr1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Tg(Camk2a-cre)2Gsc/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrl * FVB/N

Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrl

Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Cnr1tm2Ltz/Cnr1tm2Ltz
Genetic Background: B6.Cg-Cnr1tm2Ltz

 MP:0002907 abnormal parturition "defect in the process of labor and delivery in female animals " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fmr1tm1Cgr/Y
Genetic Background: involves: 129P2/OlaHsd

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002917 decreased synaptic depression "decrease in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cnr1tm2Ltz/Cnr1tm2Ltz
Genetic Background: B6.Cg-Cnr1tm2Ltz

Allelic Composition: Cnr1tm2Ltz/Cnr1tm2.1Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: B6.Cg-Cnr1tm2Ltz/Cnr1tm2.1Ltz

 MP:0002918 abnormal paired-pulse facilitation "defects in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cnr1tm1.1Ltz/Cnr1tm1.1Ltz
Genetic Background: B6.129P2-Cnr1tm1.1Ltz

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Cnr1tm1Map/Cnr1tm1Map
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Cnr1tm1.1Ltz/Cnr1tm1.1Ltz
Genetic Background: B6.129P2-Cnr1tm1.1Ltz

Allelic Composition: Cnr1tm1Map/Cnr1tm1Map
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003043 hypoalgesia "decreased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: a/a,Myo5ad/Myo5a+,Oca2p/Oca2+,Tyrp1B-lt/Tyrp1+
Genetic Background: involves: C58 * CT/Ch

 MP:0003076 increased susceptibility to ischemic brain injury "increased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [J:90111, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0003360 depression-related behavior 
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Tg(Camk2a-cre)2Gsc/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrl * FVB/N

Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Cnr1tm1Map/Cnr1tm1Map
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Cnr1tm1.1Ltz/Cnr1tm1.1Ltz
Genetic Background: B6.129P2-Cnr1tm1.1Ltz

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Cnr1tm1Map/Cnr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: a/a,Myo5ad/Myo5a+,Oca2p/Oca2+,Tyrp1B-lt/Tyrp1+
Genetic Background: involves: C58 * CT/Ch

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Cnr1tm1.1Ltz/Cnr1tm1.1Ltz
Genetic Background: B6.129P2-Cnr1tm1.1Ltz

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cnr1tm1Map/Cnr1tm1Map,Tg(HD82Gln)81Gschi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * CD-1

 MP:0004209 abnormal sweet taste sensitivity "changes in the ability to perceive a particular flavor or suggestion of something sweet by the chemoreceptors of the gustatory system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cnr1tm1Map/Cnr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Cnr1tm1.1Kpm/Cnr1tm1.1Kpm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cnr1tm1.1Kpm/Cnr1tm1.1Kpm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cnr1tm1Map/Cnr1tm1Map
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005131 increased follicle stimulating hormone level "greater than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: a/a,Myo5ad/Myo5a+,Oca2p/Oca2+,Tyrp1B-lt/Tyrp1+
Genetic Background: involves: C58 * CT/Ch

 MP:0005182 increased circulating estradiol level "greater than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: a/a,Myo5ad/Myo5a+,Oca2p/Oca2+,Tyrp1B-lt/Tyrp1+
Genetic Background: involves: C58 * CT/Ch

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
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Allelic Composition: a/a,Myo5ad/Myo5a+,Oca2p/Oca2+,Tyrp1B-lt/Tyrp1+
Genetic Background: involves: C58 * CT/Ch

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpamtm1Lex/Gpamtm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0006060 increased cerebral infarction size "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Cnr1tm1Map/Cnr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0008235 increased susceptibility to neuronal excitotoxicity "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Cnr1tm1Map/Cnr1tm1Map
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: a/a,Myo5ad/Myo5a+,Oca2p/Oca2+,Tyrp1B-lt/Tyrp1+
Genetic Background: involves: C58 * CT/Ch

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: a/a,Myo5ad/Myo5a+,Oca2p/Oca2+,Tyrp1B-lt/Tyrp1+
Genetic Background: involves: C58 * CT/Ch

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cnr1tm1Map/Cnr1tm1Map
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Cnr1tm1.1Kpm/Cnr1tm1.1Kpm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009450 abnormal axon fasiculation "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Cnr1tm1.1Ltz/Cnr1tm1.1Ltz
Genetic Background: B6.129P2-Cnr1tm1.1Ltz

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cnr1tm2Ltz/Cnr1tm2Ltz
Genetic Background: B6.Cg-Cnr1tm2Ltz

 MP:0009710 anhedonia "inability to experience pleasure in response to normally pleasurable stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cnr1tm1Map/Cnr1tm1Map
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009712 impaired conditioned place preference behavior "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cnr1tm1Map/Cnr1tm1Map
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfatc1tm3Glm/Nfatc1tm3Glm,Sh3bp2tm1Bjro/Sh3bp2tm1Bjro,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0009750 impaired behavioral response to addictive substance "decreased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cnr1tm1Map/Cnr1tm1Map
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Cnr1tm1Zim/Cnr1tm1Zim
Genetic Background: involves: 129 * C57BL/6J

 MP:0009757 impaired behavioral response to morphine "decreased sensitivity to morphine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cnr1tm1Map/Cnr1tm1Map
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cnr1tm1Map/Cnr1tm1Map
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcr4tm1Tng/Cxcr4tm1Tng
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Cnr1tm2Ltz/Cnr1tm2Ltz
Genetic Background: B6.Cg-Cnr1tm2Ltz

Allelic Composition: Cnr1tm2Ltz/Cnr1tm2.1Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: B6.Cg-Cnr1tm2Ltz/Cnr1tm2.1Ltz

 MP:0009775 increased behavioral withdrawal response "increase in the intensity or duration of behaviors displayed after discontinuation of an addictive substance" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cnr1tm1.1Kpm/Cnr1tm1.1Kpm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010119 abnormal bone mineral density "anomaly in the amount of mineral per square centimeter of bone (usually g/cm2), used as a measure of structural strength and screen for osteoporosis; bone mineral density is the ratio of bone mineral content to bone size" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cnr1tm1Map/Cnr1tm1Map
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010698 abnormal impulsive behavior control "any anomaly in the ability of an individual to exert restraint over behavior" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Tg(Camk2a-cre)2Gsc/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrl * FVB/N

Allelic Composition: Cnr1tm1.2Ltz/Cnr1tm1.2Ltz,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

 MP:0011082 abnormal gastrointestinal motility "anomaly in the propulsive movements of the digestive system, resulting in the transit of the contents along the gastrointestinal tract" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1+,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cnr1tm1Zim/Cnr1tm1Zim
Genetic Background: involves: 129 * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0012009 early parturition "the process of labor and delivery in female animals occurs earlier in gestation than expected" [MGI:csmith]
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Allelic Composition: Cnr1tm1Zim/Cnr1tm1Zim
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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