ENSMUSG00000045092


Mus musculus

Features
Gene ID: ENSMUSG00000045092
  
Biological name :S1pr1
  
Synonyms : O08530 / S1pr1 / Sphingosine 1-phosphate receptor 1
  
Possible biological names infered from orthology : P21453
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: G1
Gene start: 115710433
Gene end: 115715072
  
Corresponding Affymetrix probe sets: 10501586 (MoGene1.0st)   1423571_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050897
NCBI entrez gene - 13609     See in Manteia.
MGI - MGI:1096355
RefSeq - NM_007901
RefSeq Peptide - NP_031927
swissprot - O08530
Ensembl - ENSMUSG00000045092
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 s1pr1ENSDARG00000042690Danio rerio
 S1PR1ENSGALG00000005208Gallus gallus
 S1PR1ENSG00000170989Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
S1pr3 / Q9Z0U9 / Sphingosine 1-phosphate receptor 3 / Q99500*ENSMUSG0000006758649
S1pr5 / Q91X56 / Sphingosine 1-phosphate receptor 5 / Q9H228*ENSMUSG0000004508744
S1pr2 / P52592 / Sphingosine 1-phosphate receptor 2 / O95136*ENSMUSG0000004389544
S1pr4 / Q9Z0L1 / Sphingosine 1-phosphate receptor 4 / O95977*ENSMUSG0000004419935
Lpar1 / P61793 / Lysophosphatidic acid receptor 1 / Q92633*ENSMUSG0000003866832
Lpar2 / lysophosphatidic acid receptor 2 / Q9HBW0*ENSMUSG0000003186130
Lpar3 / Q9EQ31 / Lysophosphatidic acid receptor 3 / Q9UBY5*ENSMUSG0000003683229
Cnr1 / P47746 / Mus musculus cannabinoid receptor 1 (brain) (Cnr1), transcript variant 2, mRNA. / P21554* / cannabinoid receptor 1*ENSMUSG0000004428824
Gpr6 / Q6YNI2 / G-protein coupled receptor 6 / P46095*ENSMUSG0000004692223
Gpr12 / P35412 / G-protein coupled receptor 12 / P47775*ENSMUSG0000004146822
Gpr3 / P35413 / G-protein coupled receptor 3 / P46089*ENSMUSG0000004964921
Cnr2 / P47936 / Cannabinoid receptor 2 / P34972*ENSMUSG0000006258521


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000987  EDG-1 sphingosine 1-phosphate receptor
 IPR004061  Sphingosine 1-phosphate receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IDA
 biological_processGO:0001955 blood vessel maturation IMP
 biological_processGO:0003245 cardiac muscle tissue growth involved in heart morphogenesis IMP
 biological_processGO:0003376 sphingosine-1-phosphate signaling pathway IEA
 biological_processGO:0006935 chemotaxis IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0019226 transmission of nerve impulse IEA
 biological_processGO:0030032 lamellipodium assembly IMP
 biological_processGO:0030155 regulation of cell adhesion IDA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030500 regulation of bone mineralization IMP
 biological_processGO:0030595 leukocyte chemotaxis IDA
 biological_processGO:0031532 actin cytoskeleton reorganization IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045124 regulation of bone resorption IMP
 biological_processGO:0045446 endothelial cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050927 positive regulation of positive chemotaxis IEA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA
 biological_processGO:0051497 negative regulation of stress fiber assembly IEA
 biological_processGO:0061384 heart trabecula morphogenesis IMP
 biological_processGO:0072678 T cell migration IMP
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0009897 external side of plasma membrane IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0038036 sphingosine-1-phosphate receptor activity ISO
 molecular_functionGO:0046625 sphingolipid binding IEA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Lysosphingolipid and LPA receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000262 poor arterial differentiation "failure of or inadequate acquisition of the characteristics and/or functions of the arteries" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,S1pr1tm2Rlp/S1pr1tm2Rlp,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: S1pr1tm1Jch/S1pr1tm1Jch,Tg(GFAP-cre)25Mes/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oprm1tm1Shlz/Oprm1tm1Shlz
Genetic Background: involves: C57BL/6

Allelic Composition: S1pr1tm1.1Cys/S1pr1tm1.1Cys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,S1pr1tm2Rlp/S1pr1tm2Rlp,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: F3tm1Dco/F3tm1Dco,Tg(F3)1Nmk/0
Genetic Background: B6.Cg-F3tm1Dco Tg(F3)1Nmk

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: S1pr1tm1Jch/S1pr1tm1Jch,Tg(GFAP-cre)25Mes/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0003719 abnormal pericyte morphology "malformation in the connective tissue cells that occurs around capillaries or other small blood vessels " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003814 vascular smooth muscle cell hypoplasia "decreased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: F3tm1Dco/F3tm1Dco,Tg(F3)1Nmk/0
Genetic Background: B6.Cg-F3tm1Dco Tg(F3)1Nmk

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: S1pr1tm1Jch/S1pr1tm1Jch,Tg(GFAP-cre)25Mes/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oprm1tm1Shlz/Oprm1tm1Shlz
Genetic Background: involves: C57BL/6

Allelic Composition: S1pr1tm1.1Cys/S1pr1tm1.1Cys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: S1pr1tm1Jch/S1pr1tm1Jch,Tg(GFAP-cre)25Mes/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac

 MP:0008053 abnormal NK cell differentiation "atypical production of or inability to produce the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F3tm1Dco/F3tm1Dco,Tg(F3)1Nmk/0
Genetic Background: B6.Cg-F3tm1Dco Tg(F3)1Nmk

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F3tm1Dco/F3tm1Dco,Tg(F3)1Nmk/0
Genetic Background: B6.Cg-F3tm1Dco Tg(F3)1Nmk

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: F3tm1Dco/F3tm1Dco,Tg(F3)1Nmk/0
Genetic Background: B6.Cg-F3tm1Dco Tg(F3)1Nmk

 MP:0009864 abnormal aorta endothelium morphology "any strucutral anomaly of the thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac

 MP:0009865 abnormal aorta smooth muscle morphology "any structural anomaly of the nonstriated, involuntary muscle tissue located in the wall of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011707 impaired fibroblast cell migration "failure of cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0012501 abnormal pericardial cavity morphology "any structural anomaly of the anatomical body cavity in which the heart lies; the pericardial cavity forms in the lateral plate mesoderm above the buccopharyngeal membrane, as part of the early intraembryonic coelom, and is initially continuous with the two early pleural cavities" [MGI:anna]
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Allelic Composition: Tas1r2tm1Csz/Tas1r2tm1Csz,Tas1r3tm1Csz/Tas1r3tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0020321 increased vascular endothelial cell apoptosis "increase in the timing or the number of vascular endothelial cells undergoing programmed cell death" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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