ENSG00000170989


Homo sapiens

Features
Gene ID: ENSG00000170989
  
Biological name :S1PR1
  
Synonyms : P21453 / S1PR1 / sphingosine-1-phosphate receptor 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p21.2
Gene start: 101236888
Gene end: 101241518
  
Corresponding Affymetrix probe sets: 204642_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000305416
NCBI entrez gene - 1901     See in Manteia.
OMIM - 601974
RefSeq - NM_001400
RefSeq - NM_001320730
RefSeq Peptide - NP_001307659
RefSeq Peptide - NP_001391
swissprot - P21453
Ensembl - ENSG00000170989
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 s1pr1ENSDARG00000042690Danio rerio
 S1PR1ENSGALG00000005208Gallus gallus
 S1pr1ENSMUSG00000045092Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
S1PR3 / Q99500 / sphingosine-1-phosphate receptor 3ENSG0000021369450
S1PR5 / Q9H228 / sphingosine-1-phosphate receptor 5ENSG0000018073945
S1PR2 / O95136 / sphingosine-1-phosphate receptor 2ENSG0000026753444
S1PR4 / O95977 / sphingosine-1-phosphate receptor 4ENSG0000012591036
LPAR1 / Q92633 / lysophosphatidic acid receptor 1ENSG0000019812132
LPAR2 / Q9HBW0 / lysophosphatidic acid receptor 2ENSG0000006454730
LPAR3 / Q9UBY5 / lysophosphatidic acid receptor 3ENSG0000017151729
CNR1 / P21554 / cannabinoid receptor 1ENSG0000011843224
GPR12 / P47775 / G protein-coupled receptor 12ENSG0000013297523
GPR6 / P46095 / G protein-coupled receptor 6ENSG0000014636023
GPR3 / P46089 / G protein-coupled receptor 3ENSG0000018177321
CNR2 / P34972 / cannabinoid receptor 2ENSG0000018882221


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000987  EDG-1 sphingosine 1-phosphate receptor
 IPR004061  Sphingosine 1-phosphate receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001955 blood vessel maturation IEA
 biological_processGO:0003245 cardiac muscle tissue growth involved in heart morphogenesis IEA
 biological_processGO:0003376 sphingosine-1-phosphate signaling pathway IEA
 biological_processGO:0006935 chemotaxis ISS
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0019226 transmission of nerve impulse IEA
 biological_processGO:0030032 lamellipodium assembly IEA
 biological_processGO:0030155 regulation of cell adhesion IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030500 regulation of bone mineralization IEA
 biological_processGO:0030595 leukocyte chemotaxis IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045124 regulation of bone resorption IEA
 biological_processGO:0045446 endothelial cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050927 positive regulation of positive chemotaxis IEA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA
 biological_processGO:0051497 negative regulation of stress fiber assembly IEA
 biological_processGO:0061384 heart trabecula morphogenesis IEA
 biological_processGO:0072678 T cell migration IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IPI
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0038036 sphingosine-1-phosphate receptor activity IDA
 molecular_functionGO:0046625 sphingolipid binding IEA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Lysosphingolipid and LPA receptors
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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