ENSDARG00000041799


Danio rerio

Features
Gene ID: ENSDARG00000041799
  
Biological name :cx43
  
Synonyms : connexin 43 / cx43 / O57474
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 40715163
Gene end: 40720530
  
Corresponding Affymetrix probe sets: Dr.582.1.S1_a_at (Zebrafish Array)   NM_131038_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000061260
Ensembl peptide - ENSDARP00000114698
Ensembl peptide - ENSDARP00000127342
Ensembl peptide - ENSDARP00000150086
NCBI entrez gene - 30236     See in Manteia.
RefSeq - NM_131038
RefSeq Peptide - NP_571113
swissprot - O57474
swissprot - U3JAS3
ZFIN ID - ZDB-GENE-991105-4
Ensembl - ENSDARG00000041799
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cx40.8 / connexin 40.8 / GJA1* / P23242* / P17302* / gap junction protein alpha 1*ENSDARG0000007119265
gja3 / gap junction protein, alpha 3 / Q64448* / Q9Y6H8*ENSDARG0000002188946
cx39.9 / connexin 39.9ENSDARG0000000408241
gja8b / gap junction protein alpha 8 paralog b / GJA8* / P28236* / P48165* / gap junction protein alpha 8*ENSDARG0000001507640
cx32.3 / connexin 32.3ENSDARG0000004178739
gja5b / gap junction protein, alpha 5b / GJA5* / P36382* / Q01231* / gap junction protein alpha 5*ENSDARG0000006945038
gja8a / gap junction protein alpha 8 paralog a / GJA8* / P28236* / P48165* / gap junction protein alpha 8*ENSDARG0000006945138
cx34.5 / connexin 34.5ENSDARG0000006941138
gja5a / gap junction protein, alpha 5a / GJA5* / P36382* / Q01231* / gap junction protein alpha 5*ENSDARG0000004006537
cx52.6 / connexin 52.6 / GJA10* / Q9WUS4* / Q969M2* / gap junction protein alpha 10*ENSDARG0000003493036
cx39.4 / connexin 39.4 / GJA4* / P35212* / P28235* / gap junction protein alpha 4*ENSDARG0000007035735
cx52.7 / connexin 52.7 / GJA10* / Q9WUS4* / Q969M2* / gap junction protein alpha 10*ENSDARG0000005779234
cx32.2 / Q7T047 / connexin 32.2ENSDARG0000007678934
cx28.9 / connexin 28.9ENSDARG0000004179734
cx52.9 / connexin 52.9 / GJA9* / P57773* / gap junction protein alpha 9*ENSDARG0000008645333
cx28.1 / connexin 28.1ENSDARG0000004179231
cx47.1 / connexin 47.1 / GJC2* / Q8BQU6* / Q5T442* / gap junction protein gamma 2*ENSDARG0000007389629
cx43.4 / connexin 43.4ENSDARG0000000709929
gjd2b / gap junction protein delta 2b / GJD2* / O54851* / Q9UKL4* / gap junction protein delta 2*ENSDARG0000007078127
cx44.2 / connexin 44.2 / si:dkey-91f15.8ENSDARG0000003420727


Protein motifs (from Interpro)
Interpro ID Name
 IPR000500  Connexin
 IPR002261  Gap junction alpha-1 protein (Cx43)
 IPR013092  Connexin, N-terminal
 IPR013124  Gap junction alpha-1 protein (Cx43), C-terminal
 IPR017990  Connexin, conserved site
 IPR019570  Gap junction protein, cysteine-rich domain
 IPR034634  Connexin, C-terminal
 IPR035091  Gap junction alpha-1 protein (Cx43), alpha helix domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007154 cell communication IDA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031101 fin regeneration IMP
 biological_processGO:0033334 fin morphogenesis IGI
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0035143 caudal fin morphogenesis IMP
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060272 embryonic skeletal joint morphogenesis IMP
 biological_processGO:0060349 bone morphogenesis IMP
 biological_processGO:0070121 Kupffer"s vesicle development IMP
 biological_processGO:0098868 bone growth IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005921 gap junction IDA
 cellular_componentGO:0005922 connexin complex IC
 cellular_componentGO:0014704 intercalated disc ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005243 gap junction channel activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0022832 voltage-gated channel activity IDA
 molecular_functionGO:0022857 transmembrane transporter activity IEA
 molecular_functionGO:0055077 gap junction hemi-channel activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000033 intermediate cell mass of mesoderm intermediate cell mass of mesoderm vacuolated , abnormal
Show

 ZFA:0000107 eye eye edematous , abnormal
Show

 ZFA:0000108 fin fin decreased size , abnormal
fin decreased length , abnormal
Show

 ZFA:0000126 centrum centrum morphology , abnormal
centrum malformed , abnormal
Show

 ZFA:0000263 precaudal vertebra precaudal vertebra decreased length , abnormal
precaudal vertebra condensed , abnormal
Show

 ZFA:0000292 surface structure surface structure quality , abnormal
Show

 ZFA:0000317 postcranial axial skeleton postcranial axial skeleton morphology , abnormal
Show

 ZFA:0000326 caudal vertebra caudal vertebra decreased length , abnormal
Show

 ZFA:0000734 preural vertebra preural vertebra decreased length , abnormal
Show

 ZFA:0001058 caudal fin caudal fin proximal region increased amount , abnormal
caudal fin proximal region decreased amount , abnormal
caudal fin distal region increased amount , abnormal
caudal fin distal region decreased amount , abnormal
caudal fin medial region increased amount , abnormal
caudal fin medial region decreased amount , abnormal
caudal fin decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism shape , abnormal
whole organism dead , abnormal
whole organism decreased length , abnormal
whole organism decreased size , abnormal
Show

 ZFA:0001115 trunk trunk morphology , abnormal
trunk decreased length , abnormal
Show

 ZFA:0001117 post-vent region post-vent region bent , abnormal
Show

 ZFA:0001189 vertebra vertebra decreased length , abnormal
Show

 ZFA:0001269 regenerating fin regenerating fin decreased length , abnormal
regenerating fin decreased amount , abnormal
regenerating fin actinotrichium morphology , abnormal
regenerating fin actinotrichium decreased size , abnormal
Show

 ZFA:0001554 lepidotrichium lepidotrichium shortened , abnormal
Show

 ZFA:0001656 pleuroperitoneal cavity pleuroperitoneal cavity edematous , abnormal
Show

 ZFA:0005349 vertebra 7 vertebra 7 decreased length , abnormal
Show

 ZFA:0005350 vertebra 8 vertebra 8 decreased length , abnormal
Show

 ZFA:0005351 vertebra 9 vertebra 9 decreased length , abnormal
Show

 ZFA:0005353 vertebra 10 vertebra 10 decreased length , abnormal
Show

 ZFA:0005354 vertebra 11 vertebra 11 decreased length , abnormal
Show

 ZFA:0005596 paired fin paired fin shortened , abnormal
Show

 ZFA:0005597 median fin median fin shortened , abnormal
Show

 ZFA:0005633 lepidotrichium segment lepidotrichium segment shortened , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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