ENSDARG00000042336


Danio rerio

Features
Gene ID: ENSDARG00000042336
  
Biological name :impdh1a
  
Synonyms : impdh1a / IMP (inosine 5-monophosphate) dehydrogenase 1a / Q6GMG5
  
Possible biological names infered from orthology : IMPDH1 / Inosine-5-monophosphate dehydrogenase 1 / inosine monophosphate dehydrogenase 1 / P20839 / P50096
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 8805575
Gene end: 8842818
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000122315
Ensembl peptide - ENSDARP00000019185
Ensembl peptide - ENSDARP00000118504
NCBI entrez gene - 431724     See in Manteia.
RefSeq - XM_009293441
RefSeq - NM_001002177
RefSeq Peptide - NP_001002177
swissprot - F1QU25
swissprot - B2GRR5
swissprot - F1QLN9
swissprot - Q6GMG5
ZFIN ID - ZDB-GENE-040704-15
Ensembl - ENSDARG00000042336
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IMPDH1ENSG00000106348Homo sapiens
 Impdh1ENSMUSG00000003500Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5RGV1 / impdh1b / IMP (inosine 5-monophosphate) dehydrogenase 1b / P50096* / IMPDH1* / P20839* / inosine monophosphate dehydrogenase 1* / Inosine-5-monophosphate dehydrogenase 1 *ENSDARG0000002952488
B0UXP9 / impdh2 / IMP (inosine 5-monophosphate) dehydrogenase 2 / P24547* / P12268* / inosine monophosphate dehydrogenase 2* / Inosine-5-monophosphate dehydrogenase 2 *ENSDARG0000000690078
gmpr / guanosine monophosphate reductase / P36959* / Q9DCZ1*ENSDARG0000001616018
gmpr2 / guanosine monophosphate reductase 2 / Q99L27* / Q9P2T1*ENSDARG0000006130118


Protein motifs (from Interpro)
Interpro ID Name
 IPR000644  CBS domain
 IPR001093  IMP dehydrogenase/GMP reductase
 IPR005990  Inosine-5"-monophosphate dehydrogenase
 IPR013785  Aldolase-type TIM barrel
 IPR015875  IMP dehydrogenase / GMP reductase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development IMP
 biological_processGO:0006164 purine nucleotide biosynthetic process IEA
 biological_processGO:0006177 GMP biosynthetic process IEA
 biological_processGO:0006183 GTP biosynthetic process IBA
 biological_processGO:0048066 developmental pigmentation IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003938 IMP dehydrogenase activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Purine ribonucleoside monophosphate biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000152 retina retina decreased size , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
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 ZFA:0001114 head head melanocyte increased amount , abnormal
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 ZFA:0009198 xanthophore xanthophore absent , abnormal
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 ZFA:0009199 iridophore iridophore absent , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000042336 Q6GMG5 / impdh1a / IMP (inosine 5-monophosphate) dehydrogenase 1a / P50096* / IMPDH1* / P20839* / inosine monophosphate dehydrogenase 1* / Inosine-5-monophosphate dehydrogenase 1 *  / complex
 ENSDARG00000029524 Q5RGV1 / impdh1b / IMP (inosine 5-monophosphate) dehydrogenase 1b / P50096* / IMPDH1* / P20839* / inosine monophosphate dehydrogenase 1* / Inosine-5-monophosphate dehydrogenase 1 *  / complex






 

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