ENSMUSG00000003500


Mus musculus

Features
Gene ID: ENSMUSG00000003500
  
Biological name :Impdh1
  
Synonyms : Impdh1 / Inosine-5-monophosphate dehydrogenase 1 / P50096
  
Possible biological names infered from orthology : inosine monophosphate dehydrogenase 1 / P20839
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A3.3
Gene start: 29200434
Gene end: 29216364
  
Corresponding Affymetrix probe sets: 10543572 (MoGene1.0st)   1423239_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125077
Ensembl peptide - ENSMUSP00000124931
Ensembl peptide - ENSMUSP00000125235
Ensembl peptide - ENSMUSP00000125488
Ensembl peptide - ENSMUSP00000077289
Ensembl peptide - ENSMUSP00000123981
Ensembl peptide - ENSMUSP00000124269
Ensembl peptide - ENSMUSP00000124541
NCBI entrez gene - 23917     See in Manteia.
MGI - MGI:96567
RefSeq - XM_011241058
RefSeq - NM_001302933
RefSeq - NM_001302934
RefSeq - NM_011829
RefSeq - XM_006505065
RefSeq - XM_006505066
RefSeq Peptide - NP_001289862
RefSeq Peptide - NP_001289863
RefSeq Peptide - NP_035959
swissprot - F6XXH9
swissprot - F7DEU6
swissprot - E0CYE2
swissprot - E0CZC7
swissprot - E0CXK0
swissprot - P50096
Ensembl - ENSMUSG00000003500
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5RGV1ENSDARG00000029524Danio rerio
 Q6GMG5ENSDARG00000042336Danio rerio
 IMPDH1ENSG00000106348Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Impdh2 / P24547 / Inosine-5-monophosphate dehydrogenase 2 / P12268* / inosine monophosphate dehydrogenase 2*ENSMUSG0000006286784
Gmpr2 / Q99L27 / guanosine monophosphate reductase 2 / Q9P2T1*ENSMUSG0000000232620
Gmpr / Q9DCZ1 / guanosine monophosphate reductase / P36959*ENSMUSG0000000025319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000644  CBS domain
 IPR001093  IMP dehydrogenase/GMP reductase
 IPR005990  Inosine-5"-monophosphate dehydrogenase
 IPR013785  Aldolase-type TIM barrel
 IPR015875  IMP dehydrogenase / GMP reductase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006164 purine nucleotide biosynthetic process IMP
 biological_processGO:0006177 GMP biosynthetic process IEA
 biological_processGO:0006183 GTP biosynthetic process IBA
 biological_processGO:0046651 lymphocyte proliferation IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding ISO
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003938 IMP dehydrogenase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Purine ribonucleoside monophosphate biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx2tm1Kish/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Impdh1tm1Bmi/Impdh1tm1Bmi,Impdh2tm1Bmi/Impdh2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Impdh1tm1Bmi/Impdh1tm1Bmi,Impdh2tm1Bmi/Impdh2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Hprtb-m3/Y,Impdh1tm1Bmi/Impdh1tm1Bmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Impdh1tm1Bmi/Impdh1tm1Bmi,Impdh2tm1Bmi/Impdh2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Hprtb-m3/Y,Impdh1tm1Bmi/Impdh1tm1Bmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Runx2tm1Kish/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Impdh1tm1Bmi/Impdh1tm1Bmi,Impdh2tm1Bmi/Impdh2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Hprtb-m3/Y,Impdh1tm1Bmi/Impdh1tm1Bmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88M4Btlr/Myd88+
Genetic Background: C57BL/6J-Myd88M4Btlr

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Hprtb-m3/Y,Impdh1tm1Bmi/Impdh1tm1Bmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009335 decreased splenocyte proliferation "reduction in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Impdh1tm1Bmi/Impdh1tm1Bmi,Impdh2tm1Bmi/Impdh2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Hprtb-m3/Y,Impdh1tm1Bmi/Impdh1tm1Bmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010235 abnormal retina inner limiting membrane morphology "any structural anomaly of the row of fused Muller cell processes and astrocytes that separates the retinal nerve fiber layer from the vitreous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myd88M4Btlr/Myd88+
Genetic Background: C57BL/6J-Myd88M4Btlr

 MP:0010236 abnormal retina outer limiting membrane morphology "any structural anomaly of the row of junctional complexes between the plasma membranes of rod segments and the Muller glia cells; this barrier separates the layer of inner and outer segments of the rods and cones from the outer nuclear layer and forms a blood-retina barrier" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myd88M4Btlr/Myd88+
Genetic Background: C57BL/6J-Myd88M4Btlr

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
Show

Allelic Composition: Myd88M4Btlr/Myd88+
Genetic Background: C57BL/6J-Myd88M4Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003500 Impdh1 / P50096 / Inosine-5-monophosphate dehydrogenase 1 / P20839* / inosine monophosphate dehydrogenase 1*  / complex






 

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