ENSMUSG00000062867


Mus musculus

Features
Gene ID: ENSMUSG00000062867
  
Biological name :Impdh2
  
Synonyms : Impdh2 / Inosine-5-monophosphate dehydrogenase 2 / P24547
  
Possible biological names infered from orthology : inosine monophosphate dehydrogenase 2 / P12268
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F2
Gene start: 108560286
Gene end: 108565584
  
Corresponding Affymetrix probe sets: 10574427 (MoGene1.0st)   10589041 (MoGene1.0st)   1415851_a_at (Mouse Genome 430 2.0 Array)   1415852_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142117
Ensembl peptide - ENSMUSP00000142305
Ensembl peptide - ENSMUSP00000079888
NCBI entrez gene - 23918     See in Manteia.
MGI - MGI:109367
RefSeq - NM_011830
RefSeq - XM_006511730
RefSeq Peptide - NP_035960
swissprot - A0A0A6YY72
swissprot - P24547
swissprot - Q3UAT9
swissprot - A0A0A6YXS4
Ensembl - ENSMUSG00000062867
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 B0UXP9ENSDARG00000006900Danio rerio
 IMPDH2ENSGALG00000006910Gallus gallus
 IMPDH2ENSG00000178035Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Impdh1 / P50096 / Inosine-5-monophosphate dehydrogenase 1 / P20839* / inosine monophosphate dehydrogenase 1*ENSMUSG0000000350084
Gmpr / Q9DCZ1 / guanosine monophosphate reductase / P36959*ENSMUSG0000000025319
Gmpr2 / Q99L27 / guanosine monophosphate reductase 2 / Q9P2T1*ENSMUSG0000000232619


Protein motifs (from Interpro)
Interpro ID Name
 IPR000644  CBS domain
 IPR001093  IMP dehydrogenase/GMP reductase
 IPR005990  Inosine-5"-monophosphate dehydrogenase
 IPR013785  Aldolase-type TIM barrel
 IPR015875  IMP dehydrogenase / GMP reductase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006164 purine nucleotide biosynthetic process IMP
 biological_processGO:0006177 GMP biosynthetic process IEA
 biological_processGO:0006183 GTP biosynthetic process IBA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0046651 lymphocyte proliferation IMP
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060041 retina development in camera-type eye IEA
 biological_processGO:0071353 cellular response to interleukin-4 IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003938 IMP dehydrogenase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Purine ribonucleoside monophosphate biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx2tm1Kish/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hprtb-m3/Y,Impdh1tm1Bmi/Impdh1tm1Bmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Hprtb-m3/Y,Impdh2tm1Bmi/Impdh2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Impdh1tm1Bmi/Impdh1tm1Bmi,Impdh2tm1Bmi/Impdh2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Impdh1tm1Bmi/Impdh1tm1Bmi,Impdh2tm1Bmi/Impdh2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Hprtb-m3/Y,Impdh2tm1Bmi/Impdh2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Impdh1tm1Bmi/Impdh1tm1Bmi,Impdh2tm1Bmi/Impdh2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009335 decreased splenocyte proliferation "reduction in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Impdh1tm1Bmi/Impdh1tm1Bmi,Impdh2tm1Bmi/Impdh2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Hprtb-m3/Y,Impdh1tm1Bmi/Impdh1tm1Bmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011104 partial embryonic lethality before implantation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Hprtb-m3/Y,Impdh1tm1Bmi/Impdh1tm1Bmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000062867 Impdh2 / P24547 / Inosine-5-monophosphate dehydrogenase 2 / P12268* / inosine monophosphate dehydrogenase 2*  / complex






 

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