ENSDARG00000053493


Danio rerio

Features
Gene ID: ENSDARG00000053493
  
Biological name :aldh1a2
  
Synonyms : aldehyde dehydrogenase 1 family, member A2 / aldh1a2
  
Possible biological names infered from orthology : O94788 / Q62148 / Retinal dehydrogenase 2
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 30326184
Gene end: 30367650
  
Corresponding Affymetrix probe sets: Dr.5206.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000070001
swissprot - Q90Y03
ZFIN ID - ZDB-GENE-011010-3
Ensembl - ENSDARG00000053493
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 O93344ENSGALG00000004270Gallus gallus
 O94788ENSG00000128918Homo sapiens
 Q62148ENSMUSG00000013584Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
aldh2.2 / aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 2 / ALDH2* / P05091* / AC002996.1* / aldehyde dehydrogenase 2 family (mitochondrial)*ENSDARG0000002808765
aldh2.1 / aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 1 / ALDH2* / P05091* / AC002996.1* / aldehyde dehydrogenase 2 family (mitochondrial)*ENSDARG0000008992465
aldh1a3 / aldehyde dehydrogenase 1 family, member A3 / P47895* / Q9JHW9* / Aldehyde dehydrogenase family 1 member A3 *ENSDARG0000007693364
aldh1l1 / aldehyde dehydrogenase 1 family, member L1 / O75891*ENSDARG0000007700449
aldh1l2 / aldehyde dehydrogenase 1 family, member L2 / Q3SY69* / Q8K009* / Mitochondrial 10-formyltetrahydrofolate dehydrogenase *ENSDARG0000007023048
Q66I21 / aldh8a1 / aldehyde dehydrogenase 8 family, member A1 / Q8BH00* / Q9H2A2* / Aldehyde dehydrogenase family 8 member A1 *ENSDARG0000003677638
Q7ZVB2 / aldh9a1a.1 / aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 1 / P49189* / ALDH9A1* / aldehyde dehydrogenase 9 family member A1*ENSDARG0000006910037
aldh9a1a.2 / aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 2 / P49189* / ALDH9A1* / aldehyde dehydrogenase 9 family member A1*ENSDARG0000005533136
Q802W2 / aldh9a1b / aldehyde dehydrogenase 9 family, member A1b / P49189* / ALDH9A1* / aldehyde dehydrogenase 9 family member A1*ENSDARG0000003706135
aldh7a1 / aldehyde dehydrogenase 7 family, member A1 / P49419* / Q9DBF1* / Alpha-aminoadipic semialdehyde dehydrogenase *ENSDARG0000001842628


Protein motifs (from Interpro)
Interpro ID Name
 IPR015590  Aldehyde dehydrogenase domain
 IPR016160  Aldehyde dehydrogenase, cysteine active site
 IPR016161  Aldehyde/histidinol dehydrogenase
 IPR016162  Aldehyde dehydrogenase, N-terminal
 IPR029510  Aldehyde dehydrogenase, glutamic acid active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001889 liver development IMP
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0021575 hindbrain morphogenesis IMP
 biological_processGO:0022010 central nervous system myelination IMP
 biological_processGO:0022011 myelination in peripheral nervous system IMP
 biological_processGO:0031016 pancreas development IMP
 biological_processGO:0031101 fin regeneration IMP
 biological_processGO:0033339 pectoral fin development IMP
 biological_processGO:0039023 pronephric duct morphogenesis IMP
 biological_processGO:0042572 retinol metabolic process IGI
 biological_processGO:0048318 axial mesoderm development IMP
 biological_processGO:0048339 paraxial mesoderm development IMP
 biological_processGO:0048384 retinoic acid receptor signaling pathway IMP
 biological_processGO:0048385 regulation of retinoic acid receptor signaling pathway IMP
 biological_processGO:0048546 digestive tract morphogenesis IMP
 biological_processGO:0048593 camera-type eye morphogenesis IMP
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0048793 pronephros development IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060325 face morphogenesis IMP
 biological_processGO:0061131 pancreas field specification IMP
 biological_processGO:0072015 glomerular visceral epithelial cell development IMP
 molecular_functionGO:0004029 aldehyde dehydrogenase (NAD) activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA


Pathways (from Reactome)
Pathway description
RA biosynthesis pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000029 hindbrain hindbrain posterior region physical object quality , abnormal
hindbrain decreased length , abnormal
hindbrain kinked , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle decreased distance somite 1 , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000069 rhombomere 6 rhombomere 6 increased length , abnormal
Show

 ZFA:0000072 somite 1 somite 1 fused with somite 2 , abnormal
Show

 ZFA:0000075 spinal cord spinal cord anterior region has fewer parts of type spinal cord interneuron , abnormal
spinal cord anterior region has fewer parts of type motor neuron , abnormal
spinal cord molecular quality , abnormal
Show

 ZFA:0000076 swim bladder swim bladder quality , abnormal
swim bladder absent , abnormal
Show

 ZFA:0000084 yolk yolk deformed , abnormal
Show

 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
Show

 ZFA:0000114 heart heart quality , abnormal
heart edematous , abnormal
Show

 ZFA:0000121 lateral plate mesoderm lateral plate mesoderm physical object quality , abnormal
Show

 ZFA:0000123 liver liver decreased size , abnormal
Show

 ZFA:0000135 notochord notochord anterior region apoptotic , abnormal
Show

 ZFA:0000141 pectoral fin bud pectoral fin bud physical object quality , abnormal
pectoral fin bud aplastic , abnormal
pectoral fin bud absent , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct proximal region decreased length , abnormal
pronephric duct distal region increased length , abnormal
Show

 ZFA:0000155 somite somite decreased amount , abnormal
Show

 ZFA:0000163 renal system renal system lacks parts or has fewer parts of type podocyte , abnormal
Show

 ZFA:0000175 posterior lateral line nerve posterior lateral line nerve dendrite unbranched , abnormal
Show

 ZFA:0000369 intermandibularis intermandibularis decreased length , abnormal
Show

 ZFA:0000387 motor nucleus of vagal nerve motor nucleus of vagal nerve anatomical region decreased size , abnormal
Show

 ZFA:0000396 nervous system nervous system wholly anterioralized , abnormal
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 ZFA:0000407 pectoral girdle pectoral girdle absent , abnormal
Show

 ZFA:0000823 rhombomere 5 rhombomere 5 increased length , abnormal
rhombomere 5 decreased distance somite 1 , abnormal
Show

 ZFA:0000857 somite 4 somite 4 somitogenesis increased duration , abnormal
Show

 ZFA:0000949 rhombomere 7 rhombomere 7 physical object quality , abnormal
rhombomere 7 increased length , abnormal
Show

 ZFA:0001076 intestinal bulb intestinal bulb hypoplastic , abnormal
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 ZFA:0001094 whole organism whole organism lacks all parts of type pharyngeal pouch 3 , abnormal
whole organism lacks all parts of type pharyngeal pouch 4 , abnormal
whole organism lacks all parts of type pectoral fin , abnormal
whole organism lacks all parts of type pectoral fin cartilage , abnormal
whole organism lacks all parts of type ceratobranchial 2 cartilage , abnormal
whole organism lacks all parts of type ceratobranchial 3 cartilage , abnormal
whole organism lacks all parts of type ceratobranchial 4 cartilage , abnormal
whole organism lacks all parts of type ceratobranchial 5 cartilage , abnormal
whole organism decreased length , abnormal
whole organism lethal (sensu genetics) , abnormal
Show

 ZFA:0001114 head head misaligned with trunk , abnormal
head notochord has fewer parts of type notochord cell, abnormal
head increased size , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin quality , abnormal
pectoral fin aplastic , abnormal
pectoral fin absent , abnormal
Show

 ZFA:0001168 vertebra 2 vertebra 2 absent , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased size , abnormal
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 ZFA:0001306 pharyngeal arch pharyngeal arch absent , abnormal
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 ZFA:0001338 intestine intestine morphology , abnormal
intestine lacks all parts of type intestinal villus , abnormal
intestine lacks all parts of type columnar/cuboidal epithelial cell , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage decreased size , abnormal
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 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage decreased size , abnormal
Show

 ZFA:0001453 pectoral fin field pectoral fin field physical object quality , abnormal
Show

 ZFA:0001456 pectoral fin endoskeletal disc pectoral fin endoskeletal disc absent , abnormal
Show

 ZFA:0001559 vertebral column vertebral column anterior region decreased length , abnormal
Show

 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 neural crest apoptotic , abnormal
pharyngeal arch 3-7 absent , abnormal
pharyngeal arch 3-7 physical object quality , abnormal
Show

 ZFA:0001620 pronephric proximal convoluted tubule pronephric proximal convoluted tubule decreased length , abnormal
Show

 ZFA:0001624 pronephric distal late tubule pronephric distal late tubule increased length , abnormal
Show

 ZFA:0001651 sternohyoid sternohyoid decreased length , abnormal
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 ZFA:0001673 pronephric podocyte pronephric podocyte decreased amount , abnormal
Show

 ZFA:0005124 intestinal epithelium intestinal epithelium aplastic , abnormal
Show

 ZFA:0007052 hyohyoideus hyohyoideus decreased length , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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