ENSDARG00000077004


Danio rerio

Features
Gene ID: ENSDARG00000077004
  
Biological name :aldh1l1
  
Synonyms : aldehyde dehydrogenase 1 family, member L1 / aldh1l1
  
Possible biological names infered from orthology : Mus musculus aldehyde dehydrogenase 1 family, member L1 (Aldh1l1), transcript variant 2, mRNA. / O75891 / Q8R0Y6
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 22068589
Gene end: 22104394
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000126310
swissprot - I3ITN9
ZFIN ID - ZDB-GENE-100519-4
Ensembl - ENSDARG00000077004
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 O75891ENSG00000144908Homo sapiens
 Q8R0Y6ENSMUSG00000030088Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
aldh1l2 / aldehyde dehydrogenase 1 family, member L2 / Q3SY69* / Q8K009* / Mitochondrial 10-formyltetrahydrofolate dehydrogenase *ENSDARG0000007023077
aldh1a2 / aldehyde dehydrogenase 1 family, member A2 / O94788* / Q62148* / Retinal dehydrogenase 2 *ENSDARG0000005349328
aldh2.1 / aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 1 / ALDH2* / P05091* / AC002996.1* / aldehyde dehydrogenase 2 family (mitochondrial)*ENSDARG0000008992427
aldh2.2 / aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 2 / ALDH2* / P05091* / AC002996.1* / aldehyde dehydrogenase 2 family (mitochondrial)*ENSDARG0000002808726
aldh1a3 / aldehyde dehydrogenase 1 family, member A3 / P47895* / Q9JHW9* / Aldehyde dehydrogenase family 1 member A3 *ENSDARG0000007693326
Q66I21 / aldh8a1 / aldehyde dehydrogenase 8 family, member A1 / Q8BH00* / Q9H2A2* / Aldehyde dehydrogenase family 8 member A1 *ENSDARG0000003677621
Q802W2 / aldh9a1b / aldehyde dehydrogenase 9 family, member A1b / P49189* / ALDH9A1* / aldehyde dehydrogenase 9 family member A1*ENSDARG0000003706121
Q7ZVB2 / aldh9a1a.1 / aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 1 / P49189* / ALDH9A1* / aldehyde dehydrogenase 9 family member A1*ENSDARG0000006910021
aldh9a1a.2 / aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 2 / P49189* / ALDH9A1* / aldehyde dehydrogenase 9 family member A1*ENSDARG0000005533120
aldh7a1 / aldehyde dehydrogenase 7 family, member A1 / P49419* / Q9DBF1* / Alpha-aminoadipic semialdehyde dehydrogenase *ENSDARG0000001842615


Protein motifs (from Interpro)
Interpro ID Name
 IPR001555  Phosphoribosylglycinamide formyltransferase, active site
 IPR002376  Formyl transferase, N-terminal
 IPR005793  Formyl transferase, C-terminal
 IPR009081  Phosphopantetheine binding ACP domain
 IPR011034  Formyl transferase-like, C-terminal domain superfamily
 IPR011407  10-formyltetrahydrofolate dehydrogenase
 IPR015590  Aldehyde dehydrogenase domain
 IPR016160  Aldehyde dehydrogenase, cysteine active site
 IPR016161  Aldehyde/histidinol dehydrogenase
 IPR016162  Aldehyde dehydrogenase, N-terminal
 IPR029510  Aldehyde dehydrogenase, glutamic acid active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0007369 gastrulation IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0009258 10-formyltetrahydrofolate catabolic process IEA
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0048885 neuromast deposition IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0016155 formyltetrahydrofolate dehydrogenase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0016742 hydroxymethyl-, formyl- and related transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IDA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000045 neural crest neural crest accumulation axis , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000106 extension extension shortened , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000114 heart heart morphology , abnormal
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 ZFA:0000155 somite somite shape , abnormal
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 ZFA:0000243 neuromast neuromast displaced , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001115 trunk trunk curved , abnormal
trunk decreased length , abnormal
trunk posterior region lacks all parts of type neuromast , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage morphology , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage morphology , abnormal
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 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage absent , abnormal
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 ZFA:0009044 blood cell blood cell accumulation bulbus arteriosus , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000077004 aldh1l1 / aldehyde dehydrogenase 1 family, member L1 / O75891*  / complex






 

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