ENSG00000144908


Homo sapiens

Features
Gene ID: ENSG00000144908
  
Biological name :ALDH1L1
  
Synonyms : aldehyde dehydrogenase 1 family member L1 / ALDH1L1 / O75891
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q21.3
Gene start: 126103562
Gene end: 126197994
  
Corresponding Affymetrix probe sets: 205208_at (Human Genome U133 Plus 2.0 Array)   215798_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418905
Ensembl peptide - ENSP00000426713
Ensembl peptide - ENSP00000426594
Ensembl peptide - ENSP00000420293
Ensembl peptide - ENSP00000419955
Ensembl peptide - ENSP00000419826
Ensembl peptide - ENSP00000419448
Ensembl peptide - ENSP00000273450
Ensembl peptide - ENSP00000377081
Ensembl peptide - ENSP00000377083
Ensembl peptide - ENSP00000395881
Ensembl peptide - ENSP00000414126
Ensembl peptide - ENSP00000418711
NCBI entrez gene - 10840     See in Manteia.
OMIM - 600249
RefSeq - XM_017005614
RefSeq - NM_001270364
RefSeq - NM_001270365
RefSeq - NM_012190
RefSeq - XM_006713481
RefSeq - XM_011512355
RefSeq - XM_017005613
RefSeq Peptide - NP_001257294
RefSeq Peptide - NP_001257293
RefSeq Peptide - NP_036322
swissprot - C9JY00
swissprot - C9IZ36
swissprot - A0A0S2Z586
swissprot - C9JYZ6
swissprot - F2Z324
swissprot - F8WC34
swissprot - O75891
swissprot - D6RFJ7
Ensembl - ENSG00000144908
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aldh1l1ENSDARG00000077004Danio rerio
 Q8R0Y6ENSMUSG00000030088Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3SY69 / ALDH1L2 / aldehyde dehydrogenase 1 family member L2ENSG0000013601074
O94788 / ALDH1A2 / aldehyde dehydrogenase 1 family member A2ENSG0000012891828
P00352 / ALDH1A1 / aldehyde dehydrogenase 1 family member A1ENSG0000016509227
P30837 / ALDH1B1 / aldehyde dehydrogenase 1 family member B1ENSG0000013712427
P47895 / ALDH1A3 / aldehyde dehydrogenase 1 family member A3ENSG0000018425427
ALDH2 / P05091 / aldehyde dehydrogenase 2 family (mitochondrial)ENSG0000011127527
P49189 / ALDH9A1 / aldehyde dehydrogenase 9 family member A1ENSG0000014314922
Q9H2A2 / ALDH8A1 / aldehyde dehydrogenase 8 family member A1ENSG0000011851420
P49419 / ALDH7A1 / aldehyde dehydrogenase 7 family member A1ENSG0000016490416
AC002996.1ENSG0000025776713


Protein motifs (from Interpro)
Interpro ID Name
 IPR001555  Phosphoribosylglycinamide formyltransferase, active site
 IPR002376  Formyl transferase, N-terminal
 IPR005793  Formyl transferase, C-terminal
 IPR009081  Phosphopantetheine binding ACP domain
 IPR011034  Formyl transferase-like, C-terminal domain superfamily
 IPR011407  10-formyltetrahydrofolate dehydrogenase
 IPR015590  Aldehyde dehydrogenase domain
 IPR016160  Aldehyde dehydrogenase, cysteine active site
 IPR016161  Aldehyde/histidinol dehydrogenase
 IPR016162  Aldehyde dehydrogenase, N-terminal
 IPR029510  Aldehyde dehydrogenase, glutamic acid active site
 IPR036477  Formyl transferase, N-terminal domain superfamily
 IPR036736  ACP-like superfamily
 IPR037022  Formyl transferase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0009258 10-formyltetrahydrofolate catabolic process TAS
 biological_processGO:0046655 folic acid metabolic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003824 catalytic activity TAS
 molecular_functionGO:0004029 aldehyde dehydrogenase (NAD) activity EXP
 molecular_functionGO:0016155 formyltetrahydrofolate dehydrogenase activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0016742 hydroxymethyl-, formyl- and related transferase activity IEA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000144908 O75891 / ALDH1L1 / aldehyde dehydrogenase 1 family member L1  / complex






 

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