ENSG00000136010


Homo sapiens

Features
Gene ID: ENSG00000136010
  
Biological name :ALDH1L2
  
Synonyms : aldehyde dehydrogenase 1 family member L2 / ALDH1L2 / Q3SY69
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q23.3
Gene start: 105019784
Gene end: 105084577
  
Corresponding Affymetrix probe sets: 1556841_a_at (Human Genome U133 Plus 2.0 Array)   1559393_at (Human Genome U133 Plus 2.0 Array)   231202_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000258494
Ensembl peptide - ENSP00000447464
Ensembl peptide - ENSP00000447538
NCBI entrez gene - 160428     See in Manteia.
OMIM - 613584
RefSeq - XM_017018889
RefSeq - NM_001034173
RefSeq - XM_011537986
RefSeq - XM_011537988
RefSeq Peptide - NP_001029345
swissprot - H0YHN9
swissprot - Q3SY69
Ensembl - ENSG00000136010
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aldh1l2ENSDARG00000070230Danio rerio
 ALDH1L2ENSGALG00000012691Gallus gallus
 Q8K009ENSMUSG00000020256Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O75891 / ALDH1L1 / aldehyde dehydrogenase 1 family member L1ENSG0000014490873
P00352 / ALDH1A1 / aldehyde dehydrogenase 1 family member A1ENSG0000016509227
O94788 / ALDH1A2 / aldehyde dehydrogenase 1 family member A2ENSG0000012891827
P47895 / ALDH1A3 / aldehyde dehydrogenase 1 family member A3ENSG0000018425427
ALDH2 / P05091 / aldehyde dehydrogenase 2 family (mitochondrial)ENSG0000011127527
P30837 / ALDH1B1 / aldehyde dehydrogenase 1 family member B1ENSG0000013712426
P49189 / ALDH9A1 / aldehyde dehydrogenase 9 family member A1ENSG0000014314922
Q9H2A2 / ALDH8A1 / aldehyde dehydrogenase 8 family member A1ENSG0000011851419
P49419 / ALDH7A1 / aldehyde dehydrogenase 7 family member A1ENSG0000016490417
AC002996.1ENSG0000025776712


Protein motifs (from Interpro)
Interpro ID Name
 IPR001555  Phosphoribosylglycinamide formyltransferase, active site
 IPR002376  Formyl transferase, N-terminal
 IPR005793  Formyl transferase, C-terminal
 IPR006162  Phosphopantetheine attachment site
 IPR009081  Phosphopantetheine binding ACP domain
 IPR011034  Formyl transferase-like, C-terminal domain superfamily
 IPR011407  10-formyltetrahydrofolate dehydrogenase
 IPR015590  Aldehyde dehydrogenase domain
 IPR016160  Aldehyde dehydrogenase, cysteine active site
 IPR016161  Aldehyde/histidinol dehydrogenase
 IPR016162  Aldehyde dehydrogenase, N-terminal
 IPR029510  Aldehyde dehydrogenase, glutamic acid active site
 IPR036477  Formyl transferase, N-terminal domain superfamily
 IPR036736  ACP-like superfamily
 IPR037022  Formyl transferase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0009258 10-formyltetrahydrofolate catabolic process IEA
 biological_processGO:0046655 folic acid metabolic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004029 aldehyde dehydrogenase (NAD) activity EXP
 molecular_functionGO:0016155 formyltetrahydrofolate dehydrogenase activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0016742 hydroxymethyl-, formyl- and related transferase activity IEA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136010 Q3SY69 / ALDH1L2 / aldehyde dehydrogenase 1 family member L2  / complex






 

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