ENSG00000118514


Homo sapiens

Features
Gene ID: ENSG00000118514
  
Biological name :ALDH8A1
  
Synonyms : aldehyde dehydrogenase 8 family member A1 / ALDH8A1 / Q9H2A2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q23.3
Gene start: 134917390
Gene end: 134950122
  
Corresponding Affymetrix probe sets: 220148_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000265605
Ensembl peptide - ENSP00000356821
Ensembl peptide - ENSP00000437161
Ensembl peptide - ENSP00000435297
Ensembl peptide - ENSP00000325473
Ensembl peptide - ENSP00000356819
NCBI entrez gene - 64577     See in Manteia.
OMIM - 606467
RefSeq - NM_001193480
RefSeq - NM_022568
RefSeq - NM_170771
RefSeq Peptide - NP_072090
RefSeq Peptide - NP_739577
RefSeq Peptide - NP_001180409
swissprot - Q9H2A2
swissprot - H0YF40
swissprot - E9PKV1
Ensembl - ENSG00000118514
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q66I21ENSDARG00000036776Danio rerio
 ALDH8A1ENSGALG00000013969Gallus gallus
 Q8BH00ENSMUSG00000037542Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O94788 / ALDH1A2 / aldehyde dehydrogenase 1 family member A2ENSG0000012891838
ALDH2 / P05091 / aldehyde dehydrogenase 2 family (mitochondrial)ENSG0000011127538
P49189 / ALDH9A1 / aldehyde dehydrogenase 9 family member A1ENSG0000014314938
O75891 / ALDH1L1 / aldehyde dehydrogenase 1 family member L1ENSG0000014490838
P47895 / ALDH1A3 / aldehyde dehydrogenase 1 family member A3ENSG0000018425438
P30837 / ALDH1B1 / aldehyde dehydrogenase 1 family member B1ENSG0000013712437
Q3SY69 / ALDH1L2 / aldehyde dehydrogenase 1 family member L2ENSG0000013601037
P00352 / ALDH1A1 / aldehyde dehydrogenase 1 family member A1ENSG0000016509237
P49419 / ALDH7A1 / aldehyde dehydrogenase 7 family member A1ENSG0000016490427
AC002996.1ENSG0000025776718


Protein motifs (from Interpro)
Interpro ID Name
 IPR015590  Aldehyde dehydrogenase domain
 IPR016160  Aldehyde dehydrogenase, cysteine active site
 IPR016161  Aldehyde/histidinol dehydrogenase
 IPR016162  Aldehyde dehydrogenase, N-terminal
 IPR029510  Aldehyde dehydrogenase, glutamic acid active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0042573 retinoic acid metabolic process IDA
 biological_processGO:0042574 retinal metabolic process IDA
 biological_processGO:0042904 9-cis-retinoic acid biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001758 retinal dehydrogenase activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA


Pathways (from Reactome)
Pathway description
RA biosynthesis pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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