ENSG00000165092


Homo sapiens

Features
Gene ID: ENSG00000165092
  
Biological name :ALDH1A1
  
Synonyms : aldehyde dehydrogenase 1 family member A1 / ALDH1A1 / P00352
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q21.13
Gene start: 72900662
Gene end: 73080442
  
Corresponding Affymetrix probe sets: 212224_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000297785
Ensembl peptide - ENSP00000366138
Ensembl peptide - ENSP00000388026
Ensembl peptide - ENSP00000401361
NCBI entrez gene - 216     See in Manteia.
OMIM - 100640
RefSeq - NM_000689
RefSeq Peptide - NP_000680
swissprot - P00352
swissprot - Q5SYQ7
swissprot - Q5SYQ8
swissprot - Q5SYQ9
swissprot - V9HW83
Ensembl - ENSG00000165092
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ALDH1A1ENSGALG00000015147Gallus gallus
 O35945ENSMUSG00000024747Mus musculus
 P24549ENSMUSG00000053279Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O94788 / ALDH1A2 / aldehyde dehydrogenase 1 family member A2ENSG0000012891872
P47895 / ALDH1A3 / aldehyde dehydrogenase 1 family member A3ENSG0000018425470
ALDH2 / P05091 / aldehyde dehydrogenase 2 family (mitochondrial)ENSG0000011127568
P30837 / ALDH1B1 / aldehyde dehydrogenase 1 family member B1ENSG0000013712464
O75891 / ALDH1L1 / aldehyde dehydrogenase 1 family member L1ENSG0000014490850
Q3SY69 / ALDH1L2 / aldehyde dehydrogenase 1 family member L2ENSG0000013601049
P49189 / ALDH9A1 / aldehyde dehydrogenase 9 family member A1ENSG0000014314938
Q9H2A2 / ALDH8A1 / aldehyde dehydrogenase 8 family member A1ENSG0000011851436
AC002996.1ENSG0000025776734
P49419 / ALDH7A1 / aldehyde dehydrogenase 7 family member A1ENSG0000016490429


Protein motifs (from Interpro)
Interpro ID Name
 IPR015590  Aldehyde dehydrogenase domain
 IPR016160  Aldehyde dehydrogenase, cysteine active site
 IPR016161  Aldehyde/histidinol dehydrogenase
 IPR016162  Aldehyde dehydrogenase, N-terminal
 IPR029510  Aldehyde dehydrogenase, glutamic acid active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001523 retinoid metabolic process ISS
 biological_processGO:0006069 ethanol oxidation TAS
 biological_processGO:0006081 cellular aldehyde metabolic process TAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0042572 retinol metabolic process IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061624 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001758 retinal dehydrogenase activity TAS
 molecular_functionGO:0004029 aldehyde dehydrogenase (NAD) activity IDA
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005497 androgen binding TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0018479 benzaldehyde dehydrogenase (NAD+) activity IBA
 molecular_functionGO:0051287 NAD binding ISS


Pathways (from Reactome)
Pathway description
RA biosynthesis pathway
Fructose catabolism
Ethanol oxidation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000165092 P00352 / ALDH1A1 / aldehyde dehydrogenase 1 family member A1  / complex






 

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