ENSG00000128918


Homo sapiens

Features
Gene ID: ENSG00000128918
  
Biological name :ALDH1A2
  
Synonyms : aldehyde dehydrogenase 1 family member A2 / ALDH1A2 / O94788
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q21.3
Gene start: 57953424
Gene end: 58497866
  
Corresponding Affymetrix probe sets: 207015_s_at (Human Genome U133 Plus 2.0 Array)   207016_s_at (Human Genome U133 Plus 2.0 Array)   240435_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000453408
Ensembl peptide - ENSP00000453600
Ensembl peptide - ENSP00000454028
Ensembl peptide - ENSP00000453734
Ensembl peptide - ENSP00000249750
Ensembl peptide - ENSP00000309623
Ensembl peptide - ENSP00000416754
Ensembl peptide - ENSP00000438296
Ensembl peptide - ENSP00000452850
Ensembl peptide - ENSP00000453292
NCBI entrez gene - 8854     See in Manteia.
OMIM - 603687
RefSeq - NM_170697
RefSeq - NM_001206897
RefSeq - NM_003888
RefSeq - NM_170696
RefSeq Peptide - NP_733798
RefSeq Peptide - NP_001193826
RefSeq Peptide - NP_003879
RefSeq Peptide - NP_733797
swissprot - Q9UED3
swissprot - A0A0G2JL97
swissprot - H0YKL3
swissprot - H0YMG7
swissprot - H0YMT5
swissprot - O94788
swissprot - E9PF31
Ensembl - ENSG00000128918
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aldh1a2ENSDARG00000053493Danio rerio
 O93344ENSGALG00000004270Gallus gallus
 Q62148ENSMUSG00000013584Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P00352 / ALDH1A1 / aldehyde dehydrogenase 1 family member A1ENSG0000016509270
P47895 / ALDH1A3 / aldehyde dehydrogenase 1 family member A3ENSG0000018425469
ALDH2 / P05091 / aldehyde dehydrogenase 2 family (mitochondrial)ENSG0000011127565
P30837 / ALDH1B1 / aldehyde dehydrogenase 1 family member B1ENSG0000013712464
O75891 / ALDH1L1 / aldehyde dehydrogenase 1 family member L1ENSG0000014490849
Q3SY69 / ALDH1L2 / aldehyde dehydrogenase 1 family member L2ENSG0000013601048
P49189 / ALDH9A1 / aldehyde dehydrogenase 9 family member A1ENSG0000014314937
Q9H2A2 / ALDH8A1 / aldehyde dehydrogenase 8 family member A1ENSG0000011851436
AC002996.1ENSG0000025776731
P49419 / ALDH7A1 / aldehyde dehydrogenase 7 family member A1ENSG0000016490428


Protein motifs (from Interpro)
Interpro ID Name
 IPR015590  Aldehyde dehydrogenase domain
 IPR016160  Aldehyde dehydrogenase, cysteine active site
 IPR016161  Aldehyde/histidinol dehydrogenase
 IPR016162  Aldehyde dehydrogenase, N-terminal
 IPR029510  Aldehyde dehydrogenase, glutamic acid active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0001936 regulation of endothelial cell proliferation IEA
 biological_processGO:0002138 retinoic acid biosynthetic process IEA
 biological_processGO:0003007 heart morphogenesis IEA
 biological_processGO:0006776 vitamin A metabolic process NAS
 biological_processGO:0007494 midgut development IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0009855 determination of bilateral symmetry IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0009954 proximal/distal pattern formation IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014032 neural crest cell development IEA
 biological_processGO:0016331 morphogenesis of embryonic epithelium IEA
 biological_processGO:0021915 neural tube development IMP
 biological_processGO:0021983 pituitary gland development IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030326 embryonic limb morphogenesis IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0030902 hindbrain development IEA
 biological_processGO:0031016 pancreas development IEA
 biological_processGO:0031076 embryonic camera-type eye development IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0033189 response to vitamin A IEA
 biological_processGO:0034097 response to cytokine IDA
 biological_processGO:0035115 embryonic forelimb morphogenesis IEA
 biological_processGO:0035799 ureter maturation IEA
 biological_processGO:0042572 retinol metabolic process IEA
 biological_processGO:0042573 retinoic acid metabolic process ISS
 biological_processGO:0042574 retinal metabolic process IEA
 biological_processGO:0042904 9-cis-retinoic acid biosynthetic process IEA
 biological_processGO:0043010 camera-type eye development IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0048384 retinoic acid receptor signaling pathway IEA
 biological_processGO:0048566 embryonic digestive tract development IEA
 biological_processGO:0048738 cardiac muscle tissue development IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060324 face development IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001758 retinal dehydrogenase activity TAS
 molecular_functionGO:0004028 3-chloroallyl aldehyde dehydrogenase activity ISS
 molecular_functionGO:0004029 aldehyde dehydrogenase (NAD) activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0016918 retinal binding ISS


Pathways (from Reactome)
Pathway description
RA biosynthesis pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000128918 O94788 / ALDH1A2 / aldehyde dehydrogenase 1 family member A2  / complex






 

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