Manteia

ENSMUSG00000030088

Mus musculus

Features

Gene ID:	ENSMUSG00000030088

Biological name :	Aldh1l1

Synonyms :	Aldh1l1 / Mus musculus aldehyde dehydrogenase 1 family, member L1 (Aldh1l1), transcript variant 2, mRNA. / Q8R0Y6

Possible biological names infered from orthology :	aldehyde dehydrogenase 1 family member L1 / O75891

Species:	Mus musculus

Chr. number:	6
Strand:	1
Band:	D1
Gene start:	90486427
Gene end:	90600203

Corresponding Affymetrix probe sets:	10540034 (MoGene1.0st) 1424400_a_at (Mouse Genome 430 2.0 Array) 1424401_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000145233 Ensembl peptide - ENSMUSP00000145380 Ensembl peptide - ENSMUSP00000032175 Ensembl peptide - ENSMUSP00000114304 NCBI entrez gene - 107747 See in Manteia. MGI - MGI:1340024 RefSeq - NM_027406 RefSeq - XM_006505279 RefSeq - NM_001356412 RefSeq Peptide - NP_001343341 RefSeq Peptide - NP_081682 swissprot - A0A0N4SVT2 swissprot - Q8R0Y6 swissprot - A0A0N4SW56 Ensembl - ENSMUSG00000030088

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q8K009 / Aldh1l2 / Mitochondrial 10-formyltetrahydrofolate dehydrogenase / Q3SY69* / aldehyde dehydrogenase 1 family member L2*	ENSMUSG00000020256	75
O35945 / Aldh1a7 / Aldehyde dehydrogenase, cytosolic 1 / P00352* / ALDH1A1* / aldehyde dehydrogenase 1 family member A1*	ENSMUSG00000024747	28
Q62148 / Aldh1a2 / Retinal dehydrogenase 2 / O94788* / aldehyde dehydrogenase 1 family member A2*	ENSMUSG00000013584	27
Aldh2 / P47738 / Aldehyde dehydrogenase, mitochondrial / P05091* / AC002996.1* / aldehyde dehydrogenase 2 family (mitochondrial)*	ENSMUSG00000029455	27
Q9JHW9 / Aldh1a3 / Aldehyde dehydrogenase family 1 member A3 / P47895* / aldehyde dehydrogenase 1 family member A3*	ENSMUSG00000015134	27
Q9CZS1 / Aldh1b1 / Aldehyde dehydrogenase X, mitochondrial / P30837* / aldehyde dehydrogenase 1 family member B1*	ENSMUSG00000035561	27
P24549 / Aldh1a1 / Retinal dehydrogenase 1 / P00352* / aldehyde dehydrogenase 1 family member A1*	ENSMUSG00000053279	27
Aldh9a1 / aldehyde dehydrogenase 9 family member A1 / P49189*	ENSMUSG00000026687	21
Q8BH00 / Aldh8a1 / Aldehyde dehydrogenase family 8 member A1 / Q9H2A2* / aldehyde dehydrogenase 8 family member A1*	ENSMUSG00000037542	20
Q9DBF1 / Aldh7a1 / Alpha-aminoadipic semialdehyde dehydrogenase / P49419* / aldehyde dehydrogenase 7 family member A1*	ENSMUSG00000053644	16

Protein motifs (from Interpro)

Interpro ID	Name
IPR001555	Phosphoribosylglycinamide formyltransferase, active site
IPR002376	Formyl transferase, N-terminal
IPR005793	Formyl transferase, C-terminal
IPR009081	Phosphopantetheine binding ACP domain
IPR011034	Formyl transferase-like, C-terminal domain superfamily
IPR011407	10-formyltetrahydrofolate dehydrogenase
IPR015590	Aldehyde dehydrogenase domain
IPR016160	Aldehyde dehydrogenase, cysteine active site
IPR016161	Aldehyde/histidinol dehydrogenase
IPR016162	Aldehyde dehydrogenase, N-terminal
IPR029510	Aldehyde dehydrogenase, glutamic acid active site
IPR036477	Formyl transferase, N-terminal domain superfamily
IPR036736	ACP-like superfamily
IPR037022	Formyl transferase, C-terminal domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006730	one-carbon metabolic process	IEA
biological_process	GO:0008152	metabolic process	IEA
biological_process	GO:0009058	biosynthetic process	IEA
biological_process	GO:0009258	10-formyltetrahydrofolate catabolic process	IEA
biological_process	GO:0055114	oxidation-reduction process	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005739	mitochondrion	IDA
cellular_component	GO:0005829	cytosol	ISO
molecular_function	GO:0003824	catalytic activity	IEA
molecular_function	GO:0004029	aldehyde dehydrogenase (NAD) activity	IBA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0016155	formyltetrahydrofolate dehydrogenase activity	IBA
molecular_function	GO:0016491	oxidoreductase activity	IEA
molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA
molecular_function	GO:0016742	hydroxymethyl-, formyl- and related transferase activity	IEA

Pathways (from Reactome)

Pathway description

Metabolism of folate and pterines

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Adipor1^{tm1b(EUCOMM)Hmgu}/Adipor1^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Adipor1^{tm1b(EUCOMM)Hmgu}/H
MP:0011968	decreased threshold for auditory brainstem response	"reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system" [MGI:csmith]	Show Allelic Composition: Adipor1^{tm1b(EUCOMM)Hmgu}/Adipor1^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Adipor1^{tm1b(EUCOMM)Hmgu}/H

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000030088	Q8R0Y6 / Aldh1l1 / Mus musculus aldehyde dehydrogenase 1 family, member L1 (Aldh1l1), transcript variant 2, mRNA. / O75891* / aldehyde dehydrogenase 1 family member L1*	/ complex

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr