Manteia - Molecule gene

ENSMUSG00000029455

Mus musculus

Features

Gene ID:	ENSMUSG00000029455

Biological name :	Aldh2

Synonyms :	Aldehyde dehydrogenase, mitochondrial / Aldh2 / P47738

Possible biological names infered from orthology :	AC002996.1 / aldehyde dehydrogenase 2 family (mitochondrial) / P05091

Species:	Mus musculus

Chr. number:	5
Strand:	-1
Band:	F
Gene start:	121566027
Gene end:	121593824

Corresponding Affymetrix probe sets:	10533345 (MoGene1.0st) 1434987_at (Mouse Genome 430 2.0 Array) 1434988_x_at (Mouse Genome 430 2.0 Array) 1437410_at (Mouse Genome 430 2.0 Array) 1448143_at (Mouse Genome 430 2.0 Array) 1457155_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000031411 Ensembl peptide - ENSMUSP00000143261 Ensembl peptide - ENSMUSP00000143034 Ensembl peptide - ENSMUSP00000142906 Ensembl peptide - ENSMUSP00000123545 NCBI entrez gene - 11669 See in Manteia. MGI - MGI:99600 RefSeq - NM_009656 RefSeq - NM_001308450 RefSeq Peptide - NP_001295379 RefSeq Peptide - NP_033786 swissprot - D3YYF3 swissprot - Q544B1 swissprot - A0A0G2JFQ0 swissprot - A0A0G2JF60 swissprot - A0A0G2JEU1 swissprot - P47738 Ensembl - ENSMUSG00000029455

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
aldh2.1	ENSDARG00000089924	Danio rerio
aldh2.2	ENSDARG00000028087	Danio rerio
	ENSGALG00000004725	Gallus gallus
AC002996.1	ENSG00000257767	Homo sapiens
ALDH2	ENSG00000111275	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q9CZS1 / Aldh1b1 / Aldehyde dehydrogenase X, mitochondrial / P30837* / aldehyde dehydrogenase 1 family member B1*	ENSMUSG00000035561	72
Q62148 / Aldh1a2 / Retinal dehydrogenase 2 / O94788* / aldehyde dehydrogenase 1 family member A2*	ENSMUSG00000013584	65
P24549 / Aldh1a1 / Retinal dehydrogenase 1 / P00352* / aldehyde dehydrogenase 1 family member A1*	ENSMUSG00000053279	64
Q9JHW9 / Aldh1a3 / Aldehyde dehydrogenase family 1 member A3 / P47895* / aldehyde dehydrogenase 1 family member A3*	ENSMUSG00000015134	64
O35945 / Aldh1a7 / Aldehyde dehydrogenase, cytosolic 1 / P00352* / ALDH1A1* / aldehyde dehydrogenase 1 family member A1*	ENSMUSG00000024747	63
Q8K009 / Aldh1l2 / Mitochondrial 10-formyltetrahydrofolate dehydrogenase / Q3SY69* / aldehyde dehydrogenase 1 family member L2*	ENSMUSG00000020256	48
Q8R0Y6 / Aldh1l1 / Mus musculus aldehyde dehydrogenase 1 family, member L1 (Aldh1l1), transcript variant 2, mRNA. / O75891* / aldehyde dehydrogenase 1 family member L1*	ENSMUSG00000030088	47
Aldh9a1 / aldehyde dehydrogenase 9 family member A1 / P49189*	ENSMUSG00000026687	38
Q8BH00 / Aldh8a1 / Aldehyde dehydrogenase family 8 member A1 / Q9H2A2* / aldehyde dehydrogenase 8 family member A1*	ENSMUSG00000037542	35
Q9DBF1 / Aldh7a1 / Alpha-aminoadipic semialdehyde dehydrogenase / P49419* / aldehyde dehydrogenase 7 family member A1*	ENSMUSG00000053644	27

Protein motifs (from Interpro)

Interpro ID	Name
IPR015590	Aldehyde dehydrogenase domain
IPR016160	Aldehyde dehydrogenase, cysteine active site
IPR016161	Aldehyde/histidinol dehydrogenase
IPR016162	Aldehyde dehydrogenase, N-terminal
IPR029510	Aldehyde dehydrogenase, glutamic acid active site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006068	ethanol catabolic process	IEA
biological_process	GO:0008152	metabolic process	IEA
biological_process	GO:0055114	oxidation-reduction process	IEA
cellular_component	GO:0005739	mitochondrion	IDA
cellular_component	GO:0005759	mitochondrial matrix	IEA
molecular_function	GO:0004029	aldehyde dehydrogenase (NAD) activity	IBA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0016491	oxidoreductase activity	IEA
molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA
molecular_function	GO:0051287	NAD binding	ISS

Pathways (from Reactome)

Pathway description

Metabolism of serotonin

Ethanol oxidation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Acp2^{tm1a(EUCOMM)Wtsi}/Acp2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Acp2^{tm1a(EUCOMM)Wtsi}/H
MP:0000183	decreased circulating LDL cholesterol level	"less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mysm1^{tm1a(KOMP)Wtsi}/Mysm1⁺ Genetic Background: Not Specified
MP:0000186	decreased circulating HDL cholesterol level	"lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mysm1^{tm1a(KOMP)Wtsi}/Mysm1⁺ Genetic Background: Not Specified
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N Allelic Composition: Aldh2^tm1.1Mak/Aldh2⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J Allelic Composition: Aldh2^tm1.1Mak/Aldh2^tm1.1Mak Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0000240	extramedullary hematopoiesis	"formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0000333	decreased bone marrow cell number	"decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0000585	kinked tail	"a sharp bend or zig-zag in the tail" [J:61295]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Mirc14^tm1.1Czc/Mirc14^tm1.1Czc,Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ Genetic Background: either: (involves: 129P2/OlaHsd * 129S4/SvJae * 129S4/SvJaeSor) or (involves: 129P2/OlaHsd * 129S4/SvJae * 129S4/SvJaeSor * C57BL/6)
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0000703	abnormal thymus morphology	"anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0000914	exencephaly	"neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2⁺,Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0001188	hyperpigmentation	"excess of pigment in any or all tissues or a part of a tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50311]	Show Allelic Composition: Tlr4^Lps-8Btlr/Tlr4⁺ Genetic Background: C57BL/6J-Tlr4^Lps-8Btlr Allelic Composition: Aldh2^tm1.1Mak/Aldh2^tm1.1Mak Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Mirc14^tm1.1Czc/Mirc14^tm1.1Czc,Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ Genetic Background: either: (involves: 129P2/OlaHsd * 129S4/SvJae * 129S4/SvJaeSor) or (involves: 129P2/OlaHsd * 129S4/SvJae * 129S4/SvJaeSor * C57BL/6) Allelic Composition: Aldh2^tm1.1Mak/Aldh2⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J Allelic Composition: Aldh2^tm1.1Mak/Aldh2^tm1.1Mak Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0001293	anophthalmia	"congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0001486	abnormal startle reflex	"abberant threshold or reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]	Show Allelic Composition: Acp2^{tm1a(EUCOMM)Wtsi}/Acp2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Acp2^{tm1a(EUCOMM)Wtsi}/H
MP:0001554	increased circulating free fatty acid level	"higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]	Show Allelic Composition: Acp2^{tm1a(EUCOMM)Wtsi}/Acp2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Acp2^{tm1a(EUCOMM)Wtsi}/H
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0001606	impaired hematopoiesis	"atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0001756	abnormal urination	"anomaly in the production and excretion of urine" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Acp2^{tm1a(EUCOMM)Wtsi}/Acp2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Acp2^{tm1a(EUCOMM)Wtsi}/H
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mirc14^tm1.1Czc/Mirc14^tm1.1Czc,Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ Genetic Background: either: (involves: 129P2/OlaHsd * 129S4/SvJae * 129S4/SvJaeSor) or (involves: 129P2/OlaHsd * 129S4/SvJae * 129S4/SvJaeSor * C57BL/6)
MP:0002024	T cell derived lymphoma	"group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mirc14^tm1.1Czc/Mirc14^tm1.1Czc,Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ Genetic Background: either: (involves: 129P2/OlaHsd * 129S4/SvJae * 129S4/SvJaeSor) or (involves: 129P2/OlaHsd * 129S4/SvJae * 129S4/SvJaeSor * C57BL/6)
MP:0002092	abnormal eye morphology	"abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mirc14^tm1.1Czc/Mirc14^tm1.1Czc,Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ Genetic Background: either: (involves: 129P2/OlaHsd * 129S4/SvJae * 129S4/SvJaeSor) or (involves: 129P2/OlaHsd * 129S4/SvJae * 129S4/SvJaeSor * C57BL/6) Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2⁺,Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0002398	abnormal bone marrow cell morphology/development	"anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0002401	abnormal lymphopoiesis	"atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0002590	increased mean corpuscular volume	"greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0002736	abnormal nociception after inflammation	"changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Map7^{Gt(ROSABetageo)1Sor}/Map7^mshi Genetic Background: involves: 129S4/SvJaeSor * BALB/cBy * C57BL/6J
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0002896	abnormal bone mineralization	"defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Acp2^{tm1a(EUCOMM)Wtsi}/Acp2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Acp2^{tm1a(EUCOMM)Wtsi}/H
MP:0002966	decreased circulating alkaline phosphatase level	"reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Mysm1^{tm1a(KOMP)Wtsi}/Mysm1⁺ Genetic Background: Not Specified
MP:0003179	decreased platelet count	"fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0003546	decreased alcohol consumption	"less than normal consumption of alcohol" [RGD:Rat Genome Database submission]	Show Allelic Composition: Slc27a4^pskn/Slc27a4^pskn Genetic Background: involves: FVB
MP:0003718	maternal effect	"expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0003887	increased hepatocyte apoptosis	"increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Aldh2^tm1.1Mak/Aldh2⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J Allelic Composition: Aldh2^tm1.1Mak/Aldh2^tm1.1Mak Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0004134	abnormal chest morphology	"malformation of the part of the body between the neck and the abdomen " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:59168]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0004499	increased incidence of chemically-induced tumors	"higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Aldh2^tm1.1Mak/Aldh2⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J Allelic Composition: Aldh2^tm1.1Mak/Aldh2^tm1.1Mak Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0004810	decreased hematopoietic stem cell number	"reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Acp2^{tm1a(EUCOMM)Wtsi}/Acp2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Acp2^{tm1a(EUCOMM)Wtsi}/H
MP:0005091	increased double-positive T cell count	"greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0005152	pancytopenia	"reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mysm1^{tm1a(KOMP)Wtsi}/Mysm1⁺ Genetic Background: Not Specified
MP:0005202	lethargy	"mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0005316	abnormal response to tactile stimuli	"anomalous reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Acp2^{tm1a(EUCOMM)Wtsi}/Acp2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Acp2^{tm1a(EUCOMM)Wtsi}/H
MP:0005407	hyperalgesia	"increased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Map7^{Gt(ROSABetageo)1Sor}/Map7^mshi Genetic Background: involves: 129S4/SvJaeSor * BALB/cBy * C57BL/6J
MP:0005443	abnormal ethanol metabolism	"altered ability to metabolize the clear, colorless liquid that is the primary ingredient in alcoholic beverages" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:55555]	Show Allelic Composition: Map7^{Gt(ROSABetageo)1Sor}/Map7^mshi Genetic Background: involves: 129S4/SvJaeSor * BALB/cBy * C57BL/6J Allelic Composition: Aldh2^tm1.1Mak/Aldh2⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J Allelic Composition: Aldh2^tm1.1Mak/Aldh2^tm1.1Mak Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0005567	decreased circulating total protein level	"less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]	Show Allelic Composition: Mysm1^{tm1a(KOMP)Wtsi}/Mysm1⁺ Genetic Background: Not Specified
MP:0005584	abnormal enzyme/coenzyme activity	"altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Aldh2^tm1.1Mak/Aldh2⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J Allelic Composition: Aldh2^tm1.1Mak/Aldh2^tm1.1Mak Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0006207	embryonic lethality during organogenesis	"death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0008075	decreased CD4-positive T cell number	"reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Acp2^{tm1a(EUCOMM)Wtsi}/Acp2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Acp2^{tm1a(EUCOMM)Wtsi}/H
MP:0008078	increased CD8-positive T cell number	"greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Acp2^{tm1a(EUCOMM)Wtsi}/Acp2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Acp2^{tm1a(EUCOMM)Wtsi}/H
MP:0008873	increased sensitivity to xenobiotics	"decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0008943	increased sensitivity to induced cell death	"decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0009751	enhanced behavioral response to alcohol	"increased sensitivity to alcohol resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc27a4^pskn/Slc27a4^pskn Genetic Background: involves: FVB Allelic Composition: Aldh2^tm1.1Mak/Aldh2⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J Allelic Composition: Aldh2^tm1.1Mak/Aldh2^tm1.1Mak Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0009763	increased sensitivity to induced morbidity/mortality	"decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Aldh2^tm1.1Mak/Aldh2⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J Allelic Composition: Aldh2^tm1.1Mak/Aldh2^tm1.1Mak Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0009766	increased sensitivity to xenobiotic induced morbidity/mortality	"decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0010308	decreased tumor latency	"earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Aldh2^tm1.1Mak/Aldh2^tm1.1Mak Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0010336	increased acute lymphoblastic leukemia incidence		Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0010763	abnormal hematopoietic stem cell physiology	"any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N
MP:0010954	abnormal cellular respiration	"anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]	Show Allelic Composition: Zeb1^Tw/Zeb1⁺ Genetic Background: involves: C57BL/6J
MP:0012431	increased lymphoma incidence	"greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]	Show Allelic Composition: Aldh2^{tm1a(EUCOMM)Wtsi}/Aldh2^{tm1a(EUCOMM)Wtsi},Fancd2^tm1Hou/Fancd2^tm1Hou Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000029455	Aldh2 / P47738 / Aldehyde dehydrogenase, mitochondrial / P05091* / AC002996.1* / aldehyde dehydrogenase 2 family (mitochondrial)*	/ complex

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr