ENSDARG00000087657


Danio rerio

Features
Gene ID: ENSDARG00000087657
  
Biological name :fasn
  
Synonyms : ccdc57 / fasn / fatty acid synthase
  
Possible biological names infered from orthology : Fatty acid synthase [Acyl-carrier-protein] S-acetyltransferase [Acyl-carrier-protein] S-malonyltransferase 3-oxoacyl-[acyl-carrier-protein] synthase 3-oxoacyl-[acyl-carrier-protein] reductase 3-hydroxyacyl-[acyl-carrier-protein] dehydratase Enoyl-[acyl-carrier-protein] reductase Oleoyl-[acyl-carrier-protein] hydrolase / P19096 / P49327
  
Species: Danio rerio
  
Chr. number: 12
Strand: 1
Band:
Gene start: 33361948
Gene end: 33472581
  
Corresponding Affymetrix probe sets: Dr.6321.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000105444
Ensembl peptide - ENSDARP00000112100
Ensembl peptide - ENSDARP00000149024
Ensembl peptide - ENSDARP00000124028
Ensembl peptide - ENSDARP00000104714
NCBI entrez gene - 100318317     See in Manteia.
NCBI entrez gene - 559001     See in Manteia.
RefSeq - XM_009306806
swissprot - E7F5V3
swissprot - E7EY31
swissprot - F8W3U6
ZFIN ID - ZDB-GENE-030131-7802
ZFIN ID - ZDB-GENE-090603-1
Ensembl - ENSDARG00000087657
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FASNENSGALG00000040896Gallus gallus
 FASNENSG00000169710Homo sapiens
 FasnENSMUSG00000025153Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
si:dkey-61p9.11ENSDARG0000009676217
oxsm / 3-oxoacyl-ACP synthase, mitochondrial / Q9NWU1*ENSDARG000000988554


Protein motifs (from Interpro)
Interpro ID Name
 IPR001031  Thioesterase
 IPR006162  Phosphopantetheine attachment site
 IPR009081  Phosphopantetheine binding ACP domain
 IPR011032  GroES-like superfamily
 IPR013149  Alcohol dehydrogenase, C-terminal
 IPR013968  Polyketide synthase, ketoreductase domain
 IPR014030  Beta-ketoacyl synthase, N-terminal
 IPR014031  Beta-ketoacyl synthase, C-terminal
 IPR014043  Acyl transferase
 IPR016035  Acyl transferase/acyl hydrolase/lysophospholipase
 IPR016036  Malonyl-CoA ACP transacylase, ACP-binding
 IPR016039  Thiolase-like
 IPR016040  NAD(P)-binding domain
 IPR018201  Beta-ketoacyl synthase, active site
 IPR020801  Polyketide synthase, acyl transferase domain
 IPR020806  Polyketide synthase, phosphopantetheine-binding domain
 IPR020807  Polyketide synthase, dehydratase domain
 IPR020841  Polyketide synthase, beta-ketoacyl synthase domain
 IPR020843  Polyketide synthase, enoylreductase domain
 IPR023102  Fatty acid synthase, domain 2
 IPR029058  Alpha/Beta hydrolase fold
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase
 IPR032821  Ketoacyl-synthetase, C-terminal extension


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061959 response to (R)-carnitine IEP
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004312 fatty acid synthase activity IEA
 molecular_functionGO:0004313 [acyl-carrier-protein] S-acetyltransferase activity IEA
 molecular_functionGO:0004314 [acyl-carrier-protein] S-malonyltransferase activity IEA
 molecular_functionGO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
 molecular_functionGO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
 molecular_functionGO:0004317 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity IEA
 molecular_functionGO:0004319 enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity IEA
 molecular_functionGO:0004320 oleoyl-[acyl-carrier-protein] hydrolase activity IEA
 molecular_functionGO:0016295 myristoyl-[acyl-carrier-protein] hydrolase activity IEA
 molecular_functionGO:0016296 palmitoyl-[acyl-carrier-protein] hydrolase activity IEA
 molecular_functionGO:0016297 acyl-[acyl-carrier-protein] hydrolase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016788 hydrolase activity, acting on ester bonds IEA
 molecular_functionGO:0031177 phosphopantetheine binding IEA


Pathways (from Reactome)
Pathway description
ChREBP activates metabolic gene expression
Vitamin B5 (pantothenate) metabolism
Fatty acyl-CoA biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000087657 fasn / ccdc57 / fatty acid synthase / P19096* / P49327* / Fatty acid synthase [Acyl-carrier-protein] S-acetyltransferase [Acyl-carrier-protein] S-malonyltransferase 3-oxoacyl-[acyl-carrier-...  / reaction / complex






 

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