ENSGALG00000040896


Gallus gallus

Features
Gene ID: ENSGALG00000040896
  
Biological name :FASN
  
Synonyms : FASN / fatty acid synthase
  
Possible biological names infered from orthology : Fatty acid synthase [Acyl-carrier-protein] S-acetyltransferase [Acyl-carrier-protein] S-malonyltransferase 3-oxoacyl-[acyl-carrier-protein] synthase 3-oxoacyl-[acyl-carrier-protein] reductase 3-hydroxyacyl-[acyl-carrier-protein] dehydratase Enoyl-[acyl-carrier-protein] reductase Oleoyl-[acyl-carrier-protein] hydrolase / P19096 / P49327
  
Species: Gallus gallus
  
Chr. number: 18
Strand: 1
Band:
Gene start: 4968055
Gene end: 5062966
  
Corresponding Affymetrix probe sets: Gga.10992.1.A1_at (Chicken Array)   Gga.2448.1.S2_at (Chicken Array)   Gga.5501.1.S1_at (Chicken Array)   Gga.8951.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000048384
Ensembl peptide - ENSGALP00000059364
Ensembl peptide - ENSGALP00000055708
Ensembl peptide - ENSGALP00000048887
NCBI entrez gene - 396061     See in Manteia.
RefSeq - NM_205155
RefSeq Peptide - NP_990486
swissprot - A0A1L1RKS2
swissprot - A0A1D5PS28
swissprot - A0A1D5P842
swissprot - A0A1D5P6Q5
Ensembl - ENSGALG00000040896
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fasnENSDARG00000087657Danio rerio
 FASNENSG00000169710Homo sapiens
 FasnENSMUSG00000025153Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENSGALG000000447144
ENSGALG000000449864
OXSM* / Q9D404* / Q9NWU1* / 3-oxoacyl-ACP synthase, mitochondrial* / 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial *ENSGALG000000113121


Protein motifs (from Interpro)
Interpro ID Name
 IPR001031  Thioesterase
 IPR001227  Acyl transferase domain superfamily
 IPR006162  Phosphopantetheine attachment site
 IPR009081  Phosphopantetheine binding ACP domain
 IPR011032  GroES-like superfamily
 IPR013149  Alcohol dehydrogenase, C-terminal
 IPR013968  Polyketide synthase, ketoreductase domain
 IPR014030  Beta-ketoacyl synthase, N-terminal
 IPR014031  Beta-ketoacyl synthase, C-terminal
 IPR014043  Acyl transferase
 IPR016035  Acyl transferase/acyl hydrolase/lysophospholipase
 IPR016036  Malonyl-CoA ACP transacylase, ACP-binding
 IPR016039  Thiolase-like
 IPR016040  NAD(P)-binding domain
 IPR018201  Beta-ketoacyl synthase, active site
 IPR020801  Polyketide synthase, acyl transferase domain
 IPR020806  Polyketide synthase, phosphopantetheine-binding domain
 IPR020807  Polyketide synthase, dehydratase domain
 IPR020841  Polyketide synthase, beta-ketoacyl synthase domain
 IPR020843  Polyketide synthase, enoylreductase domain
 IPR023102  Fatty acid synthase, domain 2
 IPR029058  Alpha/Beta hydrolase fold
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase
 IPR032821  Ketoacyl-synthetase, C-terminal extension


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006089 lactate metabolic process IMP
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0030879 mammary gland development IEA
 biological_processGO:0032100 positive regulation of appetite IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071353 cellular response to interleukin-4 IEA
 cellular_componentGO:0005623 cell IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0042587 glycogen granule IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004312 fatty acid synthase activity IEA
 molecular_functionGO:0004313 [acyl-carrier-protein] S-acetyltransferase activity IEA
 molecular_functionGO:0004314 [acyl-carrier-protein] S-malonyltransferase activity IEA
 molecular_functionGO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
 molecular_functionGO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
 molecular_functionGO:0004317 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity IEA
 molecular_functionGO:0004319 enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity IEA
 molecular_functionGO:0004320 oleoyl-[acyl-carrier-protein] hydrolase activity IEA
 molecular_functionGO:0016295 myristoyl-[acyl-carrier-protein] hydrolase activity IEA
 molecular_functionGO:0016296 palmitoyl-[acyl-carrier-protein] hydrolase activity IEA
 molecular_functionGO:0016297 acyl-[acyl-carrier-protein] hydrolase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016788 hydrolase activity, acting on ester bonds IEA
 molecular_functionGO:0031177 phosphopantetheine binding IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
ChREBP activates metabolic gene expression
Vitamin B5 (pantothenate) metabolism
Fatty acyl-CoA biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000027981 AASDHPPT / aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase / Q9CQF6* / Q9NRN7* / L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase *  / reaction
 ENSGALG00000040896 FASN / fatty acid synthase / P19096* / P49327* / Fatty acid synthase [Acyl-carrier-protein] S-acetyltransferase [Acyl-carrier-protein] S-malonyltransferase 3-oxoacyl-[acyl-carrier-protein] ...  / reaction / complex






 

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