ENSG00000169710


Homo sapiens

Features
Gene ID: ENSG00000169710
  
Biological name :FASN
  
Synonyms : FASN / fatty acid synthase / P49327
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q25.3
Gene start: 82078333
Gene end: 82098332
  
Corresponding Affymetrix probe sets: 212218_s_at (Human Genome U133 Plus 2.0 Array)   217006_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000304592
Ensembl peptide - ENSP00000490921
Ensembl peptide - ENSP00000490553
Ensembl peptide - ENSP00000489808
Ensembl peptide - ENSP00000489514
Ensembl peptide - ENSP00000488964
Ensembl peptide - ENSP00000462949
NCBI entrez gene - 2194     See in Manteia.
OMIM - 600212
RefSeq - XM_011523538
RefSeq - NM_004104
RefSeq Peptide - NP_004095
swissprot - A0A0U1RQF0
swissprot - A0A1B0GVK4
swissprot - J3KTF0
swissprot - A0A1B0GWG8
swissprot - P49327
swissprot - A0A0U1RRG3
swissprot - A0A1B0GTR5
Ensembl - ENSG00000169710
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fasnENSDARG00000087657Danio rerio
 FASNENSGALG00000040896Gallus gallus
 FasnENSMUSG00000025153Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
OXSM / Q9NWU1 / 3-oxoacyl-ACP synthase, mitochondrialENSG000001510934


Protein motifs (from Interpro)
Interpro ID Name
 IPR001031  Thioesterase
 IPR006162  Phosphopantetheine attachment site
 IPR009081  Phosphopantetheine binding ACP domain
 IPR011032  GroES-like superfamily
 IPR013149  Alcohol dehydrogenase, C-terminal
 IPR013217  Methyltransferase type 12
 IPR013968  Polyketide synthase, ketoreductase domain
 IPR014030  Beta-ketoacyl synthase, N-terminal
 IPR014031  Beta-ketoacyl synthase, C-terminal
 IPR014043  Acyl transferase
 IPR016035  Acyl transferase/acyl hydrolase/lysophospholipase
 IPR016036  Malonyl-CoA ACP transacylase, ACP-binding
 IPR016039  Thiolase-like
 IPR018201  Beta-ketoacyl synthase, active site
 IPR020801  Polyketide synthase, acyl transferase domain
 IPR020806  Polyketide synthase, phosphopantetheine-binding domain
 IPR020807  Polyketide synthase, dehydratase domain
 IPR020841  Polyketide synthase, beta-ketoacyl synthase domain
 IPR020843  Polyketide synthase, enoylreductase domain
 IPR023102  Fatty acid synthase, domain 2
 IPR029058  Alpha/Beta hydrolase fold
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase
 IPR032821  Ketoacyl-synthetase, C-terminal extension
 IPR036291  NAD(P)-binding domain superfamily
 IPR036736  ACP-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation HDA
 biological_processGO:0006084 acetyl-CoA metabolic process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process TAS
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0015939 pantothenate metabolic process TAS
 biological_processGO:0030879 mammary gland development IEA
 biological_processGO:0031325 positive regulation of cellular metabolic process TAS
 biological_processGO:0045540 regulation of cholesterol biosynthetic process TAS
 biological_processGO:0046949 fatty-acyl-CoA biosynthetic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071353 cellular response to interleukin-4 IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0042587 glycogen granule IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004312 fatty acid synthase activity IEA
 molecular_functionGO:0004313 [acyl-carrier-protein] S-acetyltransferase activity IEA
 molecular_functionGO:0004314 [acyl-carrier-protein] S-malonyltransferase activity IEA
 molecular_functionGO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
 molecular_functionGO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
 molecular_functionGO:0004317 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity IEA
 molecular_functionGO:0004319 enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity IEA
 molecular_functionGO:0004320 oleoyl-[acyl-carrier-protein] hydrolase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0016295 myristoyl-[acyl-carrier-protein] hydrolase activity IEA
 molecular_functionGO:0016296 palmitoyl-[acyl-carrier-protein] hydrolase activity IEA
 molecular_functionGO:0016297 acyl-[acyl-carrier-protein] hydrolase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016788 hydrolase activity, acting on ester bonds IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0019171 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IEA
 molecular_functionGO:0031177 phosphopantetheine binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0047117 enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity IEA
 molecular_functionGO:0047451 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity IEA
 molecular_functionGO:0070402 NADPH binding IEA
 molecular_functionGO:0102131 3-oxo-glutaryl-[acp] methyl ester reductase activity IEA
 molecular_functionGO:0102132 3-oxo-pimeloyl-[acp] methyl ester reductase activity IEA


Pathways (from Reactome)
Pathway description
ChREBP activates metabolic gene expression
Vitamin B5 (pantothenate) metabolism
Activation of gene expression by SREBF (SREBP)
Fatty acyl-CoA biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000169710 FASN / P49327 / fatty acid synthase  / reaction / complex
 ENSG00000149313 Q9NRN7 / AASDHPPT / aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase  / reaction
 ENSG00000152463 OLAH / Q9NV23 / oleoyl-ACP hydrolase  / reaction






 

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