ENSMUSG00000025153


Mus musculus

Features
Gene ID: ENSMUSG00000025153
  
Biological name :Fasn
  
Synonyms : Fasn / Fatty acid synthase [Acyl-carrier-protein] S-acetyltransferase [Acyl-carrier-protein] S-malonyltransferase 3-oxoacyl-[acyl-carrier-protein] synthase 3-oxoacyl-[acyl-carrier-protein] reductase 3-hydroxyacyl-[acyl-carrier-protein] dehydratase Enoyl-[acyl-carrier-protein] reductase Oleoyl-[acyl-carrier-protein] hydrolase / P19096
  
Possible biological names infered from orthology : fatty acid synthase / P49327
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 120805846
Gene end: 120824547
  
Corresponding Affymetrix probe sets: 10393970 (MoGene1.0st)   1423828_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000052872
Ensembl peptide - ENSMUSP00000146068
Ensembl peptide - ENSMUSP00000145585
NCBI entrez gene - 14104     See in Manteia.
MGI - MGI:95485
RefSeq - NM_007988
RefSeq Peptide - NP_032014
swissprot - A0A0U1RPP5
swissprot - A0A0U1RNJ1
swissprot - P19096
Ensembl - ENSMUSG00000025153
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fasnENSDARG00000087657Danio rerio
 FASNENSGALG00000040896Gallus gallus
 FASNENSG00000169710Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Oxsm / Q9D404 / 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial / Q9NWU1* / 3-oxoacyl-ACP synthase, mitochondrial*ENSMUSG000000217864


Protein motifs (from Interpro)
Interpro ID Name
 IPR001031  Thioesterase
 IPR006162  Phosphopantetheine attachment site
 IPR009081  Phosphopantetheine binding ACP domain
 IPR011032  GroES-like superfamily
 IPR013149  Alcohol dehydrogenase, C-terminal
 IPR013217  Methyltransferase type 12
 IPR013968  Polyketide synthase, ketoreductase domain
 IPR014030  Beta-ketoacyl synthase, N-terminal
 IPR014031  Beta-ketoacyl synthase, C-terminal
 IPR014043  Acyl transferase
 IPR016035  Acyl transferase/acyl hydrolase/lysophospholipase
 IPR016036  Malonyl-CoA ACP transacylase, ACP-binding
 IPR016039  Thiolase-like
 IPR018201  Beta-ketoacyl synthase, active site
 IPR020801  Polyketide synthase, acyl transferase domain
 IPR020806  Polyketide synthase, phosphopantetheine-binding domain
 IPR020807  Polyketide synthase, dehydratase domain
 IPR020841  Polyketide synthase, beta-ketoacyl synthase domain
 IPR020843  Polyketide synthase, enoylreductase domain
 IPR023102  Fatty acid synthase, domain 2
 IPR029058  Alpha/Beta hydrolase fold
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase
 IPR032821  Ketoacyl-synthetase, C-terminal extension
 IPR036291  NAD(P)-binding domain superfamily
 IPR036736  ACP-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006084 acetyl-CoA metabolic process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IDA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0030879 mammary gland development IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071353 cellular response to interleukin-4 IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0042587 glycogen granule IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004312 fatty acid synthase activity IEA
 molecular_functionGO:0004313 [acyl-carrier-protein] S-acetyltransferase activity IEA
 molecular_functionGO:0004314 [acyl-carrier-protein] S-malonyltransferase activity IEA
 molecular_functionGO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
 molecular_functionGO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
 molecular_functionGO:0004317 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity IEA
 molecular_functionGO:0004319 enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity IEA
 molecular_functionGO:0004320 oleoyl-[acyl-carrier-protein] hydrolase activity IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0016295 myristoyl-[acyl-carrier-protein] hydrolase activity IEA
 molecular_functionGO:0016296 palmitoyl-[acyl-carrier-protein] hydrolase activity IEA
 molecular_functionGO:0016297 acyl-[acyl-carrier-protein] hydrolase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016788 hydrolase activity, acting on ester bonds IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0019171 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IEA
 molecular_functionGO:0031177 phosphopantetheine binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0047117 enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity IEA
 molecular_functionGO:0047451 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity IEA
 molecular_functionGO:0070402 NADPH binding IEA
 molecular_functionGO:0102131 3-oxo-glutaryl-[acp] methyl ester reductase activity IEA
 molecular_functionGO:0102132 3-oxo-pimeloyl-[acp] methyl ester reductase activity IEA


Pathways (from Reactome)
Pathway description
ChREBP activates metabolic gene expression
Vitamin B5 (pantothenate) metabolism
Fatty acyl-CoA biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Grid2tm1Mmsh/Grid2tm1Mmsh
Genetic Background: involves: C57BL/6N

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Grid2tm1Mmsh/Grid2tm1Mmsh
Genetic Background: involves: C57BL/6N

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
Show

Allelic Composition: Grid2tm1Mmsh/Grid2tm1Mmsh
Genetic Background: involves: C57BL/6N

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Grid2tm1Mmsh/Grid2tm1Mmsh
Genetic Background: involves: C57BL/6N

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Grid2tm1Mmsh/Grid2tm1Mmsh
Genetic Background: involves: C57BL/6N

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fasntm1Sem/Fasntm1Sem,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grid2tm1Mmsh/Grid2tm1Mmsh
Genetic Background: involves: C57BL/6N

 MP:0002712 increased circulating glucagon level "greater than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fasntm1Sem/Fasntm1Sem,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fasntm1Sem/Fasntm1Sem,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fasntm1Sem/Fasntm1Sem,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Grid2tm1Mmsh/Grid2tm1Mmsh
Genetic Background: involves: C57BL/6N

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fasntm1Sem/Fasntm1Sem,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0005280 abnormal fatty acid level "anomalous concentration of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Grid2tm1Mmsh/Grid2tm1Mmsh
Genetic Background: involves: C57BL/6N

 MP:0005286 decreased saturated fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons in which the carbon chain contains only single carbon-carbon bonds " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fasntm1Sem/Fasntm1Sem,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Grid2tm1Mmsh/Grid2tm1Mmsh
Genetic Background: involves: C57BL/6N

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fasntm1Sem/Fasntm1Sem,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Grid2tm1Mmsh/Grid2tm1Mmsh
Genetic Background: involves: C57BL/6N

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fasntm1Sem/Fasntm1Sem,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0005645 abnormal hypothalamus physiology "anomalous function of the ventral and medial region of the diencephalon forming the walls of the ventral half of the third ventricle, which is normally involved in the functions of the autonomic (visceral motor) nervous system and, through its vascular link with the anterior lobe of the pituitary gland, in endocrine mechanisms" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grid2tm1Mmsh/Grid2tm1Mmsh
Genetic Background: involves: C57BL/6N

 MP:0006204 embryonic lethality before implantation "death anytime after fertilization but before implantation (E0 to less than E4.5)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kittm2Bsm/Kit+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008907 decreased total fat pad weight "less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fasntm1Sem/Fasntm1Sem,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fasntm1Sem/Fasntm1Sem,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fasntm1Sem/Fasntm1Sem,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Fasntm1Sem/Fasntm1Sem,Tg(Ins2-cre)25Mgn/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0010026 decreased liver cholesterol level "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fasntm1Sem/Fasntm1Sem,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Fasntm1Sem/Fasntm1Sem,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Fasntm1Schi/Fasn+
Genetic Background: 129S7/SvEvBrd-Fasntm1Schi

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Kittm2Bsm/Kit+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Fasntm1Schi/Fasn+
Genetic Background: 129S7/SvEvBrd-Fasntm1Schi

 MP:0011957 decreased compensatory feeding amount "decreased amount of food consumed after a period of fasting" [MGI:csmith]
Show

Allelic Composition: Fasntm1Sem/Fasntm1Sem,Tg(Ins2-cre)25Mgn/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025894 Q9CQF6 / Aasdhppt / L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase / Q9NRN7* / aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase*  / reaction
 ENSMUSG00000025153 Fasn / P19096 / Fatty acid synthase [Acyl-carrier-protein] S-acetyltransferase [Acyl-carrier-protein] S-malonyltransferase 3-oxoacyl-[acyl-carrier-protein] synthase 3-oxoacyl-[acyl-carrier-p...  / complex / reaction






 

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