ENSDARG00000099079


Danio rerio

Features
Gene ID: ENSDARG00000099079
  
Biological name :aclya
  
Synonyms : aclya / ATP citrate lyase a
  
Possible biological names infered from orthology : ACLY / ATP citrate lyase / P53396 / Q91V92
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 17951790
Gene end: 18009316
  
Corresponding Affymetrix probe sets: Dr.22172.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000131909
swissprot - F1QZ09
ZFIN ID - ZDB-GENE-031113-1
Ensembl - ENSDARG00000099079
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ACLYENSGALG00000003475Gallus gallus
 ACLYENSG00000131473Homo sapiens
 AclyENSMUSG00000020917Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
aclyb / ATP citrate lyase b / ACLY* / P53396* / Q91V92* / ATP citrate lyase*ENSDARG0000005565284
suclg1 / succinate-CoA ligase, alpha subunit / P53597* / Q9WUM5* / Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial *ENSDARG000000527128


Protein motifs (from Interpro)
Interpro ID Name
 IPR002020  Citrate synthase
 IPR003781  CoA-binding
 IPR005811  ATP-citrate lyase/succinyl-CoA ligase
 IPR014608  ATP-citrate synthase
 IPR016040  NAD(P)-binding domain
 IPR016102  Succinyl-CoA synthetase-like
 IPR016142  Citrate synthase-like, large alpha subdomain
 IPR016143  Citrate synthase-like, small alpha subdomain
 IPR017440  ATP-citrate lyase/succinyl-CoA ligase, active site
 IPR017866  Succinyl-CoA synthetase, beta subunit, conserved site
 IPR032263  ATP-citrate synthase, citrate-binding domain
 IPR033847  ATP-citrate lyase/succinyl-CoA ligase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006085 acetyl-CoA biosynthetic process IBA
 biological_processGO:0006101 citrate metabolic process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IBA
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0009346 citrate lyase complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003878 ATP citrate synthase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer IEA
 molecular_functionGO:0048037 cofactor binding IEA


Pathways (from Reactome)
Pathway description
ChREBP activates metabolic gene expression
Neutrophil degranulation
Fatty acyl-CoA biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000075 spinal cord spinal cord motor neuron axon guidance decreased process quality , abnormal
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 ZFA:0001056 myotome myotome acetylcholine-gated channel complex increased distribution , abnormal
myotome acetylcholine-gated channel complex increased area , abnormal
myotome regulation of synaptic transmission, cholinergic decreased process quality , abnormal
myotome neuromuscular junction of skeletal muscle fiber area , abnormal
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 ZFA:0009052 motor neuron motor neuron axon decreased length , abnormal
motor neuron neuronal cell body mislocalised , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000099079 aclya / ATP citrate lyase a / ACLY* / P53396* / Q91V92* / ATP citrate lyase*  / complex
 ENSDARG00000055652 aclyb / ATP citrate lyase b / ACLY* / P53396* / Q91V92* / ATP citrate lyase*  / complex






 

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