ENSMUSG00000020917


Mus musculus

Features
Gene ID: ENSMUSG00000020917
  
Biological name :Acly
  
Synonyms : Acly / ATP citrate lyase / Q91V92
  
Possible biological names infered from orthology : P53396
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 100476353
Gene end: 100528000
  
Corresponding Affymetrix probe sets: 10391146 (MoGene1.0st)   1425326_at (Mouse Genome 430 2.0 Array)   1438389_x_at (Mouse Genome 430 2.0 Array)   1439445_x_at (Mouse Genome 430 2.0 Array)   1439459_x_at (Mouse Genome 430 2.0 Array)   1446315_at (Mouse Genome 430 2.0 Array)   1451666_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000007131
Ensembl peptide - ENSMUSP00000103008
Ensembl peptide - ENSMUSP00000103012
Ensembl peptide - ENSMUSP00000127632
NCBI entrez gene - 104112     See in Manteia.
MGI - MGI:103251
RefSeq - NM_001199296
RefSeq - NM_134037
RefSeq Peptide - NP_001186225
RefSeq Peptide - NP_598798
swissprot - Q3TS02
swissprot - Q3V117
swissprot - Q91V92
Ensembl - ENSMUSG00000020917
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aclyaENSDARG00000099079Danio rerio
 aclybENSDARG00000055652Danio rerio
 ACLYENSGALG00000003475Gallus gallus
 ACLYENSG00000131473Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9WUM5 / Suclg1 / Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial / P53597* / succinate-CoA ligase alpha subunit*ENSMUSG000000527389


Protein motifs (from Interpro)
Interpro ID Name
 IPR002020  Citrate synthase
 IPR003781  CoA-binding
 IPR005811  ATP-citrate lyase/succinyl-CoA ligase
 IPR014608  ATP-citrate synthase
 IPR016102  Succinyl-CoA synthetase-like
 IPR016142  Citrate synthase-like, large alpha subdomain
 IPR016143  Citrate synthase-like, small alpha subdomain
 IPR017440  ATP-citrate lyase/succinyl-CoA ligase, active site
 IPR017866  Succinyl-CoA synthetase, beta subunit, conserved site
 IPR032263  ATP-citrate synthase, citrate-binding domain
 IPR033847  ATP-citrate lyase/succinyl-CoA ligase, conserved site
 IPR036291  NAD(P)-binding domain superfamily
 IPR036969  Citrate synthase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006085 acetyl-CoA biosynthetic process IBA
 biological_processGO:0006101 citrate metabolic process ISO
 biological_processGO:0006107 oxaloacetate metabolic process ISS
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IBA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008610 lipid biosynthetic process ISS
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009346 citrate lyase complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003878 ATP citrate synthase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer IEA
 molecular_functionGO:0048037 cofactor binding IEA


Pathways (from Reactome)
Pathway description
ChREBP activates metabolic gene expression
Neutrophil degranulation
Fatty acyl-CoA biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Lmx1atm1Ics/Lmx1atm1Ics,Lmx1btm1Rjo/Lmx1b+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Sim1tm1Fan/Sim1+,Sim2tm1Fan/Sim2+
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020917 Acly / Q91V92 / ATP citrate lyase / P53396*  / complex






 

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