ENSG00000131473


Homo sapiens

Features
Gene ID: ENSG00000131473
  
Biological name :ACLY
  
Synonyms : ACLY / ATP citrate lyase / P53396
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.2
Gene start: 41866908
Gene end: 41930542
  
Corresponding Affymetrix probe sets: 201127_s_at (Human Genome U133 Plus 2.0 Array)   201128_s_at (Human Genome U133 Plus 2.0 Array)   210337_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464717
Ensembl peptide - ENSP00000445349
Ensembl peptide - ENSP00000466259
Ensembl peptide - ENSP00000468705
Ensembl peptide - ENSP00000253792
Ensembl peptide - ENSP00000345398
Ensembl peptide - ENSP00000377474
NCBI entrez gene - 47     See in Manteia.
OMIM - 108728
RefSeq - XM_017024688
RefSeq - NM_001096
RefSeq - NM_001303274
RefSeq - NM_001303275
RefSeq - NM_198830
RefSeq - XM_005257395
RefSeq Peptide - NP_001290203
RefSeq Peptide - NP_001087
RefSeq Peptide - NP_001290204
RefSeq Peptide - NP_942127
swissprot - K7ESG8
swissprot - A0A024R1Y2
swissprot - A0A024R1T9
swissprot - P53396
swissprot - K7EIE7
Ensembl - ENSG00000131473
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aclyaENSDARG00000099079Danio rerio
 aclybENSDARG00000055652Danio rerio
 ACLYENSGALG00000003475Gallus gallus
 AclyENSMUSG00000020917Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P53597 / SUCLG1 / succinate-CoA ligase alpha subunitENSG000001635419


Protein motifs (from Interpro)
Interpro ID Name
 IPR002020  Citrate synthase
 IPR003781  CoA-binding
 IPR005811  ATP-citrate lyase/succinyl-CoA ligase
 IPR014608  ATP-citrate synthase
 IPR016102  Succinyl-CoA synthetase-like
 IPR016142  Citrate synthase-like, large alpha subdomain
 IPR016143  Citrate synthase-like, small alpha subdomain
 IPR017440  ATP-citrate lyase/succinyl-CoA ligase, active site
 IPR017866  Succinyl-CoA synthetase, beta subunit, conserved site
 IPR032263  ATP-citrate synthase, citrate-binding domain
 IPR033847  ATP-citrate lyase/succinyl-CoA ligase, conserved site
 IPR036291  NAD(P)-binding domain superfamily
 IPR036969  Citrate synthase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006085 acetyl-CoA biosynthetic process IDA
 biological_processGO:0006101 citrate metabolic process IDA
 biological_processGO:0006107 oxaloacetate metabolic process IDA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IBA
 biological_processGO:0006695 cholesterol biosynthetic process TAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008610 lipid biosynthetic process IDA
 biological_processGO:0015936 coenzyme A metabolic process TAS
 biological_processGO:0031325 positive regulation of cellular metabolic process TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0046949 fatty-acyl-CoA biosynthetic process TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009346 citrate lyase complex IBA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003878 ATP citrate synthase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer IEA
 molecular_functionGO:0048037 cofactor binding IEA


Pathways (from Reactome)
Pathway description
ChREBP activates metabolic gene expression
Neutrophil degranulation
Fatty acyl-CoA biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000131473 ACLY / P53396 / ATP citrate lyase  / complex






 

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