ENSDARG00000101239


Danio rerio

Features
Gene ID: ENSDARG00000101239
  
Biological name :hsd17b4
  
Synonyms : hsd17b4 / hydroxysteroid (17-beta) dehydrogenase 4
  
Possible biological names infered from orthology : P51659 / P51660 / Q9DAH1 / Q9UJQ7 / SCP2D1 / SCP2 sterol binding domain containing 1 / SCP2 sterol-binding domain-containing protein 1
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 41688
Gene end: 65189
  
Corresponding Affymetrix probe sets: Dr.20943.1.A1_at (Zebrafish Array)   Dr.4883.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000136011
NCBI entrez gene - 393105     See in Manteia.
swissprot - A0A0R4INZ2
swissprot - Q8AYH1
ZFIN ID - ZDB-GENE-040421-1
Ensembl - ENSDARG00000101239
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HSD17B4ENSGALG00000002187Gallus gallus
 P51659ENSG00000133835Homo sapiens
 Q9UJQ7ENSG00000132631Homo sapiens
 P51660ENSMUSG00000024507Mus musculus
 Q9DAH1ENSMUSG00000027431Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
scp2a / sterol carrier protein 2a / SCP2* / P32020* / P22307* / sterol carrier protein 2* / sterol carrier protein 2, liver*ENSDARG0000001219414
scp2b / sterol carrier protein 2bENSDARG000001023566


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR002539  MaoC-like domain
 IPR003033  SCP2 sterol-binding domain
 IPR016040  NAD(P)-binding domain
 IPR020904  Short-chain dehydrogenase/reductase, conserved site
 IPR029069  HotDog domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0048568 embryonic organ development IMP
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
alpha-linolenic acid (ALA) metabolism
Beta-oxidation of pristanoyl-CoA
Beta-oxidation of very long chain fatty acids
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000084 yolk yolk increased size , abnormal
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 ZFA:0000123 liver liver decreased size , abnormal
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 ZFA:0000140 pancreas pancreas absent , abnormal
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 ZFA:0001094 whole organism whole organism decreased amount , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001115 trunk trunk curved , abnormal
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 ZFA:0009052 motor neuron motor neuron axonogenesis disrupted , abnormal
motor neuron axon development disrupted , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
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 ZFA:0009298 terminal Schwann cell terminal Schwann cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000101239 hsd17b4 / hydroxysteroid (17-beta) dehydrogenase 4 / P51659* / Q9UJQ7* / SCP2D1* / SCP2 sterol binding domain containing 1*  / complex






 

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