ENSMUSG00000024507


Mus musculus

Features
Gene ID: ENSMUSG00000024507
  
Biological name :Hsd17b4
  
Synonyms : Hsd17b4 / hydroxysteroid (17-beta) dehydrogenase 4 / P51660
  
Possible biological names infered from orthology : P51659
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: D1
Gene start: 50128201
Gene end: 50196269
  
Corresponding Affymetrix probe sets: 10455656 (MoGene1.0st)   1417369_at (Mouse Genome 430 2.0 Array)   1455777_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025385
NCBI entrez gene - 15488     See in Manteia.
MGI - MGI:105089
RefSeq - NM_008292
RefSeq Peptide - NP_032318
swissprot - P51660
Ensembl - ENSMUSG00000024507
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hsd17b4ENSDARG00000101239Danio rerio
 HSD17B4ENSGALG00000002187Gallus gallus
 P51659ENSG00000133835Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Scp2 / P32020 / sterol carrier protein 2, liver / P22307* / sterol carrier protein 2*ENSMUSG0000002860314
Q9DAH1 / Scp2d1 / SCP2 sterol-binding domain-containing protein 1 / Q9UJQ7* / SCP2 sterol binding domain containing 1*ENSMUSG000000274318


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR002539  MaoC-like domain
 IPR003033  SCP2 sterol-binding domain
 IPR020904  Short-chain dehydrogenase/reductase, conserved site
 IPR029069  HotDog domain superfamily
 IPR036291  NAD(P)-binding domain superfamily
 IPR036527  SCP2 sterol-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000038 very long-chain fatty acid metabolic process IMP
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006635 fatty acid beta-oxidation IEA
 biological_processGO:0008209 androgen metabolic process ISO
 biological_processGO:0008210 estrogen metabolic process ISO
 biological_processGO:0036111 very long-chain fatty-acyl-CoA metabolic process ISO
 biological_processGO:0036112 medium-chain fatty-acyl-CoA metabolic process ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060009 Sertoli cell development IMP
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005777 peroxisome ISO
 molecular_functionGO:0003857 3-hydroxyacyl-CoA dehydrogenase activity ISO
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016508 long-chain-enoyl-CoA hydratase activity ISO
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0033989 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0044594 17-beta-hydroxysteroid dehydrogenase (NAD+) activity ISO


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
alpha-linolenic acid (ALA) metabolism
Beta-oxidation of pristanoyl-CoA
Beta-oxidation of very long chain fatty acids
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Grid2ho-16J/Grid2ho-16J
Genetic Background: C57BL/6J-Grid2ho-16J/J

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Hsd17b4tm2Baes/Hsd17b4tm2Baes,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Hsd17b4tm2Baes/Hsd17b4tm2Baes,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hsd17b4tm2Baes/Hsd17b4tm2Baes,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Hsd17b4tm2Baes/Hsd17b4tm2Baes,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Hsd17b4tm2Baes/Hsd17b4tm2Baes,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Hsd17b4tm2Baes/Hsd17b4tm2Baes,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Hsd17b4tm2Baes/Hsd17b4tm2Baes,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Hsd17b4tm2Baes/Hsd17b4tm2Baes,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
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Allelic Composition: Hsd17b4tm2Baes/Hsd17b4tm2Baes,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001666 abnormal nutrient absorption "anomalous ability of the body to take in constituents of food necessary for normal physiologic function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Hsd17b4tm2Baes/Hsd17b4tm2Baes,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Hsd17b4tm2Baes/Hsd17b4tm2Baes,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Hsd17b4tm2Baes/Hsd17b4tm2Baes,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hsd17b4tm2Baes/Hsd17b4tm2Baes,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Hsd17b4tm2Baes/Hsd17b4tm2Baes,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Asah1tm1.1Jhkh/Asah1+,Smpd1tm1Esc/Smpd1+
Genetic Background: involves: 129S1/Sv

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hsd17b4tm2Baes/Hsd17b4tm2Baes,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0004144 hypotonia "decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004774 abnormal bile salt level "anomalous concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Hsd17b4tm2Baes/Hsd17b4tm2Baes,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Hsd17b4tm2Baes/Hsd17b4tm2Baes,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Hsd17b4tm2Baes/Hsd17b4tm2Baes,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Hsd17b4tm2Baes/Hsd17b4tm2Baes,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Slc19a2tm1Ejn/Slc19a2tm1Ejn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Ehhadhtm1Jkr/Ehhadhtm1Jkr,Hsd17b4tm1Baes/Hsd17b4tm1Baes
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0014185 cerebellum atrophy "acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna]
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Allelic Composition: Hsd17b4tm2Baes/Hsd17b4tm2Baes,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020087 Q9DBA6 / Tysnd1 / trypsin domain containing 1 / Q2T9J0*  / reaction
 ENSMUSG00000024507 P51660 / Hsd17b4 / hydroxysteroid (17-beta) dehydrogenase 4 / P51659*  / complex






 

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