ENSMUSG00000028603


Mus musculus

Features
Gene ID: ENSMUSG00000028603
  
Biological name :Scp2
  
Synonyms : P32020 / Scp2 / sterol carrier protein 2, liver
  
Possible biological names infered from orthology : P22307 / sterol carrier protein 2
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C7
Gene start: 108043839
Gene end: 108144998
  
Corresponding Affymetrix probe sets: 10514956 (MoGene1.0st)   1419974_at (Mouse Genome 430 2.0 Array)   1419975_at (Mouse Genome 430 2.0 Array)   1426219_at (Mouse Genome 430 2.0 Array)   1449686_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102312
Ensembl peptide - ENSMUSP00000123630
Ensembl peptide - ENSMUSP00000121673
Ensembl peptide - ENSMUSP00000030340
NCBI entrez gene - 20280     See in Manteia.
MGI - MGI:98254
RefSeq - NM_011327
RefSeq - XM_011240477
RefSeq Peptide - NP_035457
swissprot - A2APS5
swissprot - P32020
swissprot - A2APS4
Ensembl - ENSMUSG00000028603
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scp2aENSDARG00000012194Danio rerio
 SCP2ENSGALG00000010652Gallus gallus
 SCP2ENSG00000116171Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P51660 / Hsd17b4 / hydroxysteroid (17-beta) dehydrogenase 4 / P51659*ENSMUSG0000002450719
Q9DAH1 / Scp2d1 / SCP2 sterol-binding domain-containing protein 1 / Q9UJQ7* / SCP2 sterol binding domain containing 1*ENSMUSG000000274319


Protein motifs (from Interpro)
Interpro ID Name
 IPR003033  SCP2 sterol-binding domain
 IPR016039  Thiolase-like
 IPR020613  Thiolase, conserved site
 IPR020615  Thiolase, acyl-enzyme intermediate active site
 IPR020616  Thiolase, N-terminal
 IPR020617  Thiolase, C-terminal
 IPR036527  SCP2 sterol-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006637 acyl-CoA metabolic process TAS
 biological_processGO:0006694 steroid biosynthetic process IBA
 biological_processGO:0006701 progesterone biosynthetic process ISO
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0007031 peroxisome organization IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0015914 phospholipid transport IBA
 biological_processGO:0030301 cholesterol transport IBA
 biological_processGO:0032385 positive regulation of intracellular cholesterol transport ISO
 biological_processGO:0032959 inositol trisphosphate biosynthetic process ISO
 biological_processGO:0045940 positive regulation of steroid metabolic process ISO
 biological_processGO:0072659 protein localization to plasma membrane ISO
 biological_processGO:1901373 lipid hydroperoxide transport ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005777 peroxisome TAS
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0000062 fatty-acyl-CoA binding ISO
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0008526 phosphatidylinositol transporter activity ISO
 molecular_functionGO:0015248 sterol transporter activity IBA
 molecular_functionGO:0015485 cholesterol binding ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups IEA
 molecular_functionGO:0032934 sterol binding IBA
 molecular_functionGO:0033814 propanoyl-CoA C-acyltransferase activity IEA
 molecular_functionGO:0036042 long-chain fatty acyl-CoA binding ISO
 molecular_functionGO:0050632 propionyl-CoA C2-trimethyltridecanoyltransferase activity TAS
 molecular_functionGO:0070538 oleic acid binding ISO


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
alpha-linolenic acid (ALA) metabolism
Beta-oxidation of pristanoyl-CoA
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Sulf1tm1.1Cpe/Sulf1tm1.1Cpe,Sulf2tm1.1Cpe/Sulf2tm1.1Cpe
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Sulf1tm1.1Cpe/Sulf1tm1.1Cpe,Sulf2tm1.1Cpe/Sulf2tm1.1Cpe
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000606 decreased hepatocyte number "fewer than normal number of parenchymal liver cells" [J:23170]
Show

Allelic Composition: Scp2tm1Kier/Scp2tm1Kier
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCr

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Maddtm1Ytk/Maddtm1Ytk
Genetic Background: involves: 129X1/SvJ

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

Allelic Composition: Scp2tm1Kier/Scp2tm1Kier
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCr

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Scp2tm1Kier/Scp2tm1Kier
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCr

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scp2tm1Kier/Scp2tm1Kier
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCr

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Scp2tm1Kier/Scp2tm1Kier
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCr

 MP:0004772 abnormal bile secretion "any anomaly in the quantity or rate of bile secreted through the bile ducts in a given length of time" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

 MP:0004774 abnormal bile salt level "anomalous concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

 MP:0005145 increased circulating VLDL cholesterol level "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Scp2tm1Kier/Scp2tm1Kier
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCr

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

Allelic Composition: Scp2tm1Kier/Scp2tm1Kier
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCr

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

Allelic Composition: Scp2tm1Kier/Scp2tm1Kier
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCr

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scp2tm1Kier/Scp2tm1Kier
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCr

 MP:0010026 decreased liver cholesterol level "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scp2tm1Kier/Scp2tm1Kier
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020087 Q9DBA6 / Tysnd1 / trypsin domain containing 1 / Q2T9J0*  / reaction






 

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