ENSDARG00000103125


Danio rerio

Features
Gene ID: ENSDARG00000103125
  
Biological name :tsc2
  
Synonyms : tsc2 / TSC complex subunit 2
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 54198893
Gene end: 54274861
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000131915
Ensembl peptide - ENSDARP00000143378
NCBI entrez gene - 567524     See in Manteia.
RefSeq - NM_001328401
RefSeq - XM_021475603
RefSeq Peptide - NP_001315330
swissprot - A0A286Y892
swissprot - A0A0G2KHX4
ZFIN ID - ZDB-GENE-030131-2702
Ensembl - ENSDARG00000103125
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ralgapa1 / Ral GTPase activating protein, alpha subunit 1 (catalytic) / Q6GYQ0* / Q6GYP7* / Ral GTPase activating protein, alpha subunit 1* / Ral GTPase activating protein catalytic alpha subunit 1*ENSDARG0000007688915
ralgapa2 / Ral GTPase activating protein, alpha subunit 2 (catalytic) / Q2PPJ7* / A3KGS3* / Ral GTPase-activating protein subunit alpha-2 * / Ral GTPase activating protein catalytic alpha subunit 2*ENSDARG0000000586115
sipa1l1 / signal-induced proliferation-associated 1 like 1 / O43166* / Q8C0T5* / Signal-induced proliferation-associated 1-like protein 1 *ENSDARG000000201349
sipa1l2 / signal-induced proliferation-associated 1 like 2 / Q80TE4* / Q9P2F8* / Mus musculus signal-induced proliferation-associated 1 like 2 (Sipa1l2), transcript variant 2, mRNA.*ENSDARG000000616408
sipa1l3 / signal-induced proliferation-associated 1 like 3 / G3X9J0* / O60292*ENSDARG000000616998
zmp:0000001168 / SIPA1* / Q96FS4* / signal-induced proliferation-associated 1*ENSDARG000000766975
rap1gap2b / RAP1 GTPase activating protein 2b / Q5SVL6* / Q684P5* / RAP1GAP2* / RAP1 GTPase activating protein 2*ENSDARG000000742224
A5PF44 / si:ch211-182d3.1 / GARNL3* / Q5VVW2* / GTPase activating Rap/RanGAP domain like 3*ENSDARG000000606314
rap1gap2a / RAP1 GTPase activating protein 2a / Q5SVL6* / Q684P5* / RAP1GAP2* / RAP1 GTPase activating protein 2*ENSDARG000000615513
si:ch1073-90m23.1ENSDARG000000915733
si:dkey-166d12.2 / P47736* / RAP1GAP* / RAP1 GTPase activating protein*ENSDARG000000532723
rap1gap / RAP1 GTPase activating protein / A2ALS5* / P47736* / Mus musculus Rap1 GTPase-activating protein (Rap1gap), transcript variant 5, mRNA.*ENSDARG000000565543
CABZ01067150.1ENSDARG000001161220


Protein motifs (from Interpro)
Interpro ID Name
 IPR000331  Rap GTPase activating protein domain
 IPR003913  Tuberin
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR018515  Tuberin-type domain
 IPR021133  HEAT, type 2
 IPR024584  Tuberin, N-terminal
 IPR027107  Tuberin/Ral GTPase-activating protein subunit alpha


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IBA
 biological_processGO:0032007 negative regulation of TOR signaling IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IBA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction IEA
 biological_processGO:0051726 regulation of cell cycle IBA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IBA
 biological_processGO:0060575 intestinal epithelial cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0033596 TSC1-TSC2 complex IEA
 molecular_functionGO:0005096 GTPase activator activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
brain protein serine/threonine kinase activity increased occurrence , abnormal
Show

 ZFA:0000075 spinal cord spinal cord increased diameter , abnormal
spinal cord protein serine/threonine kinase activity increased occurrence , abnormal
Show

 ZFA:0000076 swim bladder swim bladder collapsed , abnormal
Show

 ZFA:0000101 diencephalon diencephalon anterior region disorganized , abnormal
Show

 ZFA:0000107 eye eye protein serine/threonine kinase activity increased occurrence , abnormal
Show

 ZFA:0000123 liver liver color , abnormal
liver increased size , abnormal
liver fatty , abnormal
liver protein serine/threonine kinase activity increased occurrence , abnormal
Show

 ZFA:0000304 ventral telencephalon ventral telencephalon dorsal region increased width , abnormal
ventral telencephalon dorsal region disorganized , abnormal
Show

 ZFA:0000505 dorsal telencephalon dorsal telencephalon increased size , abnormal
dorsal telencephalon disorganized , abnormal
Show

 ZFA:0000529 kidney kidney protein serine/threonine kinase activity increased occurrence , abnormal
Show

 ZFA:0000597 telencephalic white matter telencephalic white matter composition , abnormal
Show

 ZFA:0000696 telencephalic ventricle telencephalic ventricle morphology , abnormal
Show

 ZFA:0001094 whole organism whole organism viability , abnormal
Show

 ZFA:0001338 intestine intestine protein serine/threonine kinase activity increased occurrence , abnormal
Show

 ZFA:0005314 blood vessel blood vessel increased diameter , abnormal
Show

 ZFA:0009067 CNS neuron (sensu Vertebrata) CNS neuron (sensu Vertebrata) cell body increased size , abnormal
CNS neuron (sensu Vertebrata) mislocalised , abnormal
Show

 ZFA:0009111 hepatocyte hepatocyte ballooning , abnormal
hepatocyte increased size , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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