ENSDARG00000104573


Danio rerio

Features
Gene ID: ENSDARG00000104573
  
Biological name :slc12a2
  
Synonyms : slc12a2 / solute carrier family 12 (sodium/potassium/chloride transporter), member 2
  
Possible biological names infered from orthology : P55011 / solute carrier family 12 member 2
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 16225117
Gene end: 16310179
  
Corresponding Affymetrix probe sets: Dr.17930.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000105107
Ensembl peptide - ENSDARP00000135730
Ensembl peptide - ENSDARP00000131505
NCBI entrez gene - 415170     See in Manteia.
RefSeq - NM_001163654
RefSeq - XM_021479152
RefSeq Peptide - NP_001157126
swissprot - A0A0G2KGS0
swissprot - E7FG36
swissprot - A0A0G2KTI4
ZFIN ID - ZDB-GENE-040625-53
Ensembl - ENSDARG00000104573
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLC12A2ENSGALG00000014690Gallus gallus
 P55011ENSG00000064651Homo sapiens
 Slc12a2ENSMUSG00000024597Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
slc12a3 / solute carrier family 12 (sodium/chloride transporter), member 3 / P55017* / P59158* / solute carrier family 12 member 3*ENSDARG0000001385544
slc12a10.1 / solute carrier family 12 (sodium/potassium/chloride transporters), member 10, tandem duplicate 1ENSDARG0000005531341
slc12a10.2 / solute carrier family 12 (sodium/potassium/chloride transporters), member 10, tandem duplicate 2ENSDARG0000007117339
slc12a10.3 / slc12a10.3 solute carrier family 12 (sodium/potassium/chloride transporters), member 10, tandem duplicate 3ENSDARG0000005525339
slc12a1 / solute carrier family 12 (sodium/potassium/chloride transporter), member 1 / Q13621* / solute carrier family 12 member 1*ENSDARG0000009809636
slc12a4 / solute carrier family 12 (potassium/chloride transporter), member 4 / Q9JIS8* / Q9UP95* / solute carrier family 12 member 4*ENSDARG0000001437825
slc12a5b / solute carrier family 12 (potassium/chloride transporter), member 5b / Q91V14* / Q9H2X9* / SLC12A5* / solute carrier family 12 member 5*ENSDARG0000007818724
slc12a7b / solute carrier family 12 (potassium/chloride transporter), member 7b / Q9WVL3* / Q9Y666* / SLC12A7* / solute carrier family 12 member 7*ENSDARG0000006205824
CABZ01063543.1 / P55011* / SLC12A2* / solute carrier family 12 member 2*ENSDARG0000011304524
slc12a5a / solute carrier family 12 (potassium/chloride transporter), member 5a / Q91V14* / Q9H2X9* / SLC12A5* / solute carrier family 12 member 5*ENSDARG0000007581523
slc12a7a / solute carrier family 12 (potassium/chloride transporter), member 7a / Q9WVL3* / Q9Y666* / SLC12A7* / solute carrier family 12 member 7*ENSDARG0000007375623
A2BFP5 / slc12a9 / solute carrier family 12, member 9 / Q99MR3* / Q9BXP2*ENSDARG0000006036621
zgc:153039ENSDARG0000010272421
slc12a8 / solute carrier family 12, member 8 / A0AV02* / Q8VI23* / solute carrier family 12 (potassium/chloride transporters), member 8*ENSDARG0000007438416
si:cabz01090193.1 / Q9UHW9* / Q924N4* / Gm21985* / SLC12A6* / solute carrier family 12 member 6*ENSDARG000001054855


Protein motifs (from Interpro)
Interpro ID Name
 IPR002443  Na/K/Cl co-transporter
 IPR002444  Na/K/Cl co-transporter 1
 IPR004841  Amino acid permease/ SLC12A domain
 IPR004842  SLC12A transporter family
 IPR013612  Amino acid permease, N-terminal
 IPR018491  SLC12A transporter, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0043583 ear development IMP
 biological_processGO:0048798 swim bladder inflation IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0072488 ammonium transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IBA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0008519 ammonium transmembrane transporter activity IBA
 molecular_functionGO:0015377 cation:chloride symporter activity IEA


Pathways (from Reactome)
Pathway description
Cation-coupled Chloride cotransporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
brain morphology , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle morphology , abnormal
Show

 ZFA:0000076 swim bladder swim bladder increased length , abnormal
swim bladder increased volume , abnormal
Show

 ZFA:0000107 eye eye quality , abnormal
Show

 ZFA:0000135 notochord notochord morphology , abnormal
Show

 ZFA:0000155 somite somite morphology , abnormal
Show

 ZFA:0000168 anterior macula anterior macula morphology , abnormal
Show

 ZFA:0000217 inner ear inner ear quality , abnormal
inner ear decreased size , abnormal
inner ear collapsed , abnormal
inner ear morphology , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000386 macula macula crowded , abnormal
Show

 ZFA:0000431 semicircular canal semicircular canal morphology , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism balance , abnormal
whole organism movement behavioral quality , abnormal
whole organism unbalanced , abnormal
whole organism circling , abnormal
Show

 ZFA:0001206 intermediate mesoderm intermediate mesoderm morphology , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0009090 pigment cell pigment cell quality , abnormal
Show

 ZFA:0009091 melanocyte melanocyte area , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr