ENSG00000064651


Homo sapiens

Features
Gene ID: ENSG00000064651
  
Biological name :SLC12A2
  
Synonyms : P55011 / SLC12A2 / solute carrier family 12 member 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q23.3
Gene start: 128083766
Gene end: 128189688
  
Corresponding Affymetrix probe sets: 204404_at (Human Genome U133 Plus 2.0 Array)   225835_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262461
Ensembl peptide - ENSP00000340878
Ensembl peptide - ENSP00000427109
Ensembl peptide - ENSP00000486323
NCBI entrez gene - 6558     See in Manteia.
OMIM - 600840
RefSeq - XM_017009771
RefSeq - NM_001046
RefSeq - NM_001256461
RefSeq Peptide - NP_001037
RefSeq Peptide - NP_001243390
swissprot - P55011
swissprot - Q53ZR1
swissprot - G3XAL9
Ensembl - ENSG00000064651
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01063543.1ENSDARG00000113045Danio rerio
 slc12a2ENSDARG00000104573Danio rerio
 SLC12A2ENSGALG00000014690Gallus gallus
 Slc12a2ENSMUSG00000024597Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q13621 / SLC12A1 / solute carrier family 12 member 1ENSG0000007480358
P55017 / SLC12A3 / solute carrier family 12 member 3ENSG0000007091544
Q9H2X9 / SLC12A5 / solute carrier family 12 member 5ENSG0000012414024
Q9Y666 / SLC12A7 / solute carrier family 12 member 7ENSG0000011350424
Q9UP95 / SLC12A4 / solute carrier family 12 member 4ENSG0000012406724
Q9UHW9 / SLC12A6 / solute carrier family 12 member 6ENSG0000014019923
Q9BXP2 / SLC12A9 / solute carrier family 12 member 9ENSG0000014682820
A0AV02 / SLC12A8 / solute carrier family 12 member 8ENSG0000022195515


Protein motifs (from Interpro)
Interpro ID Name
 IPR002443  Na/K/Cl co-transporter
 IPR002444  Na/K/Cl co-transporter 1
 IPR004841  Amino acid permease/ SLC12A domain
 IPR004842  SLC12A transporter family
 IPR013612  Amino acid permease, N-terminal
 IPR018491  SLC12A transporter, C-terminal
 IPR036640  ABC transporter type 1, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0006972 hyperosmotic response IEA
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0015696 ammonium transport IDA
 biological_processGO:0030321 transepithelial chloride transport IDA
 biological_processGO:0045795 positive regulation of cell volume IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070634 transepithelial ammonium transport IDA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:0072488 ammonium transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IBA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1903561 extracellular vesicle HDA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008511 sodium:potassium:chloride symporter activity TAS
 molecular_functionGO:0008519 ammonium transmembrane transporter activity IDA
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0015377 cation:chloride symporter activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
Cation-coupled Chloride cotransporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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