ENSG00000124067


Homo sapiens

Features
Gene ID: ENSG00000124067
  
Biological name :SLC12A4
  
Synonyms : Q9UP95 / SLC12A4 / solute carrier family 12 member 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q22.1
Gene start: 67943474
Gene end: 67969601
  
Corresponding Affymetrix probe sets: 209400_at (Human Genome U133 Plus 2.0 Array)   209401_s_at (Human Genome U133 Plus 2.0 Array)   209402_s_at (Human Genome U133 Plus 2.0 Array)   211112_at (Human Genome U133 Plus 2.0 Array)   228644_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464660
Ensembl peptide - ENSP00000445962
Ensembl peptide - ENSP00000438334
Ensembl peptide - ENSP00000395983
Ensembl peptide - ENSP00000318557
Ensembl peptide - ENSP00000463148
Ensembl peptide - ENSP00000464168
Ensembl peptide - ENSP00000458902
Ensembl peptide - ENSP00000458975
Ensembl peptide - ENSP00000461403
NCBI entrez gene - 6560     See in Manteia.
OMIM - 604119
RefSeq - NM_005072
RefSeq - NM_001145961
RefSeq - NM_001145962
RefSeq - NM_001145963
RefSeq - NM_001145964
RefSeq Peptide - NP_001139433
RefSeq Peptide - NP_005063
RefSeq Peptide - NP_001139436
RefSeq Peptide - NP_001139435
RefSeq Peptide - NP_001139434
swissprot - Q9UP95
swissprot - I3L1N8
swissprot - I3L4N6
swissprot - J3QKM4
swissprot - J3QRE2
swissprot - J3QSF2
Ensembl - ENSG00000124067
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc12a4ENSDARG00000014378Danio rerio
 SLC12A4ENSGALG00000034179Gallus gallus
 Q9JIS8ENSMUSG00000017765Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UHW9 / SLC12A6 / solute carrier family 12 member 6ENSG0000014019974
Q9Y666 / SLC12A7 / solute carrier family 12 member 7ENSG0000011350468
Q9H2X9 / SLC12A5 / solute carrier family 12 member 5ENSG0000012414068
P55011 / SLC12A2 / solute carrier family 12 member 2ENSG0000006465126
Q13621 / SLC12A1 / solute carrier family 12 member 1ENSG0000007480325
P55017 / SLC12A3 / solute carrier family 12 member 3ENSG0000007091524
Q9BXP2 / SLC12A9 / solute carrier family 12 member 9ENSG0000014682821
A0AV02 / SLC12A8 / solute carrier family 12 member 8ENSG0000022195516


Protein motifs (from Interpro)
Interpro ID Name
 IPR000076  K/Cl co-transporter
 IPR000622  K/Cl co-transporter 1
 IPR004841  Amino acid permease/ SLC12A domain
 IPR004842  SLC12A transporter family
 IPR018491  SLC12A transporter, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport TAS
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006884 cell volume homeostasis TAS
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071477 cellular hypotonic salinity response IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005765 lysosomal membrane HDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0015377 cation:chloride symporter activity IEA
 molecular_functionGO:0015379 potassium:chloride symporter activity TAS
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
Cation-coupled Chloride cotransporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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