ENSG00000015171


Homo sapiens

Features
Gene ID: ENSG00000015171
  
Biological name :ZMYND11
  
Synonyms : Q15326 / zinc finger MYND-type containing 11 / ZMYND11
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: p15.3
Gene start: 134465
Gene end: 254637
  
Corresponding Affymetrix probe sets: 1554158_at (Human Genome U133 Plus 2.0 Array)   1554159_a_at (Human Genome U133 Plus 2.0 Array)   202136_at (Human Genome U133 Plus 2.0 Array)   202137_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000385484
Ensembl peptide - ENSP00000381053
Ensembl peptide - ENSP00000386010
Ensembl peptide - ENSP00000487386
Ensembl peptide - ENSP00000473321
Ensembl peptide - ENSP00000452959
Ensembl peptide - ENSP00000424205
Ensembl peptide - ENSP00000397072
Ensembl peptide - ENSP00000309992
Ensembl peptide - ENSP00000370996
Ensembl peptide - ENSP00000371003
Ensembl peptide - ENSP00000371017
Ensembl peptide - ENSP00000371020
Ensembl peptide - ENSP00000381046
Ensembl peptide - ENSP00000381050
NCBI entrez gene - 10771     See in Manteia.
OMIM - 608668
RefSeq - XM_017015594
RefSeq - NM_001202466
RefSeq - NM_001202467
RefSeq - NM_001202468
RefSeq - NM_006624
RefSeq - NM_212479
RefSeq - XM_005252359
RefSeq - XM_005252361
RefSeq - XM_005252362
RefSeq - XM_006717376
RefSeq - XM_017015587
RefSeq - XM_017015588
RefSeq - XM_017015589
RefSeq - XM_017015590
RefSeq - XM_017015591
RefSeq - XM_017015592
RefSeq - XM_017015593
RefSeq - NM_001202464
RefSeq - NM_001202465
RefSeq Peptide - NP_001189395
RefSeq Peptide - NP_001189396
RefSeq Peptide - NP_001189397
RefSeq Peptide - NP_001316986
RefSeq Peptide - NP_006615
RefSeq Peptide - NP_997644
RefSeq Peptide - NP_001189393
RefSeq Peptide - NP_001189394
swissprot - Q15326
swissprot - E7EV75
swissprot - E7ENI9
swissprot - B7Z2J6
swissprot - B0QZE2
swissprot - J3QKD2
swissprot - A0A0A0MRY2
swissprot - E9PE09
Ensembl - ENSG00000015171
  
Related genetic diseases (OMIM): 616083 - Mental retardation, autosomal dominant 30, 616083
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zmynd11ENSDARG00000057249Danio rerio
 ZMYND11ENSGALG00000006599Gallus gallus
 Q8R5C8ENSMUSG00000021156Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9ULU4 / ZMYND8 / zinc finger MYND-type containing 8ENSG0000010104031
TAF1 / P21675 / TATA-box binding protein associated factor 1ENSG0000014713315
TAF1L / Q8IZX4 / TATA-box binding protein associated factor 1 likeENSG0000012272814


Protein motifs (from Interpro)
Interpro ID Name
 IPR000313  PWWP domain
 IPR001487  Bromodomain
 IPR001965  Zinc finger, PHD-type
 IPR002893  Zinc finger, MYND-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR035505  ZMYND8/11, PWWP domain
 IPR036427  Bromodomain-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0034243 regulation of transcription elongation from RNA polymerase II promoter ISS
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0046329 negative regulation of JNK cascade IMP
 biological_processGO:0051607 defense response to virus IDA
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003690 double-stranded DNA binding IDA
 molecular_functionGO:0003712 transcription coregulator activity IBA
 molecular_functionGO:0003714 transcription corepressor activity ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0035064 methylated histone binding ISS
 molecular_functionGO:0042393 histone binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0000154 Wide mouth "Abnormally wide mouth." [HPO:curators]
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 HP:0000316 Hypertelorism 
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 HP:0000508 Ptosis "Drooping of the eyelid." [HPO:curators]
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 HP:0000718 Aggressive behavior "Aggressive behavior can denote verbal aggression, physical aggression against objects, physical aggression against people, and may also include aggression towards oneself." [HPO:curators]
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 HP:0000750 Impaired language development 
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 HP:0001256 Mental retardation, mild "Mild mental retardation is defined as an intelligence quotient (IQ) in the range of 50-69." [HPO:curators]
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 HP:0001263 Developmental retardation "A delay in the achievement of motor or mental milestones manifested prior to age 18 and generally associated with lifelong mental and/or physical impairments." [HPO:curators]
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 HP:0001999 Facial dysmorphism 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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