ENSG00000063244


Homo sapiens

Features
Gene ID: ENSG00000063244
  
Biological name :U2AF2
  
Synonyms : P26368 / U2AF2 / U2 small nuclear RNA auxiliary factor 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.42
Gene start: 55654146
Gene end: 55674715
  
Corresponding Affymetrix probe sets: 214171_s_at (Human Genome U133 Plus 2.0 Array)   218381_s_at (Human Genome U133 Plus 2.0 Array)   218382_s_at (Human Genome U133 Plus 2.0 Array)   229508_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000388475
Ensembl peptide - ENSP00000466935
Ensembl peptide - ENSP00000470020
Ensembl peptide - ENSP00000307863
Ensembl peptide - ENSP00000466167
NCBI entrez gene - 11338     See in Manteia.
OMIM - 191318
RefSeq - XM_011526410
RefSeq - NM_001012478
RefSeq - NM_007279
RefSeq - XM_006722994
RefSeq Peptide - NP_001012496
RefSeq Peptide - NP_009210
swissprot - K7ELP8
swissprot - K7ENG2
swissprot - M0QYQ9
swissprot - P26368
Ensembl - ENSG00000063244
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 u2af2aENSDARG00000012505Danio rerio
 u2af2bENSDARG00000011740Danio rerio
 U2af2ENSMUSG00000030435Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
UHMK1 / Q8TAS1 / U2AF homology motif kinase 1ENSG0000015233216


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR006529  U2 snRNP auxilliary factor, large subunit, splicing factor
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome IC
 biological_processGO:0006369 termination of RNA polymerase II transcription TAS
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006405 RNA export from nucleus TAS
 biological_processGO:0006406 mRNA export from nucleus TAS
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0031124 mRNA 3"-end processing TAS
 biological_processGO:0031397 negative regulation of protein ubiquitination IMP
 biological_processGO:0033120 positive regulation of RNA splicing IDA
 biological_processGO:0048025 negative regulation of mRNA splicing, via spliceosome IDA
 cellular_componentGO:0000243 commitment complex IBA
 cellular_componentGO:0000974 Prp19 complex IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005681 spliceosomal complex IDA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0071004 U2-type prespliceosome IDA
 cellular_componentGO:0089701 U2AF IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008187 poly-pyrimidine tract binding IBA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0030628 pre-mRNA 3"-splice site binding IDA
 molecular_functionGO:0070742 C2H2 zinc finger domain binding IEA


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA Splicing - Major Pathway
mRNA 3-end processing


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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