ENSG00000067066


Homo sapiens

Features
Gene ID: ENSG00000067066
  
Biological name :SP100
  
Synonyms : P23497 / SP100 / SP100 nuclear antigen
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q37.1
Gene start: 230415942
Gene end: 230544090
  
Corresponding Affymetrix probe sets: 202863_at (Human Genome U133 Plus 2.0 Array)   202864_s_at (Human Genome U133 Plus 2.0 Array)   210218_s_at (Human Genome U133 Plus 2.0 Array)   210219_at (Human Genome U133 Plus 2.0 Array)   210985_s_at (Human Genome U133 Plus 2.0 Array)   237426_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000399389
Ensembl peptide - ENSP00000416563
Ensembl peptide - ENSP00000393679
Ensembl peptide - ENSP00000400277
Ensembl peptide - ENSP00000264052
Ensembl peptide - ENSP00000343023
Ensembl peptide - ENSP00000386404
Ensembl peptide - ENSP00000386427
Ensembl peptide - ENSP00000386998
Ensembl peptide - ENSP00000387311
Ensembl peptide - ENSP00000391616
NCBI entrez gene - 6672     See in Manteia.
OMIM - 604585
RefSeq - NM_001080391
RefSeq - NM_001206702
RefSeq - NM_001206703
RefSeq - NM_001206704
RefSeq - NM_003113
RefSeq - NM_001206701
RefSeq Peptide - NP_001073860
RefSeq Peptide - NP_001193631
RefSeq Peptide - NP_001193632
RefSeq Peptide - NP_001193633
RefSeq Peptide - NP_003104
RefSeq Peptide - NP_001193630
swissprot - P23497
swissprot - C9JBL0
swissprot - E9PHV6
swissprot - H0Y4R8
swissprot - H7C1G8
swissprot - H7C4B4
Ensembl - ENSG00000067066
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sp100.1ENSDARG00000055359Danio rerio
 sp100.2ENSDARG00000102588Danio rerio
 sp100.3ENSDARG00000090449Danio rerio
 Sp100ENSMUSG00000026222Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9H930 / SP140L / SP140 nuclear body protein likeENSG0000018540437
SP140 / Q13342 / SP140 nuclear body proteinENSG0000007926334
SP110 / Q9HB58 / SP110 nuclear body proteinENSG0000013589923


Protein motifs (from Interpro)
Interpro ID Name
 IPR000770  SAND domain
 IPR001487  Bromodomain
 IPR001965  Zinc finger, PHD-type
 IPR004865  HSR domain
 IPR009071  High mobility group box domain
 IPR010919  SAND-like domain superfamily
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR036427  Bromodomain-like superfamily
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000723 telomere maintenance IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA
 biological_processGO:0010596 negative regulation of endothelial cell migration IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0034340 response to type I interferon IMP
 biological_processGO:0034341 response to interferon-gamma IMP
 biological_processGO:0043392 negative regulation of DNA binding IDA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0045185 maintenance of protein location IDA
 biological_processGO:0045765 regulation of angiogenesis IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0046826 negative regulation of protein export from nucleus IMP
 biological_processGO:0051271 negative regulation of cellular component movement IMP
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway IC
 biological_processGO:0060337 type I interferon signaling pathway IC
 biological_processGO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
 biological_processGO:1902044 regulation of Fas signaling pathway IMP
 cellular_componentGO:0000784 nuclear chromosome, telomeric region HDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0030870 Mre11 complex IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070087 chromo shadow domain binding IPI


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins
Interferon gamma signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction / complex






 

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