ENSG00000078295


Homo sapiens

Features
Gene ID: ENSG00000078295
  
Biological name :ADCY2
  
Synonyms : ADCY2 / adenylate cyclase 2 / Q08462
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: p15.31
Gene start: 7396208
Gene end: 7830081
  
Corresponding Affymetrix probe sets: 213217_at (Human Genome U133 Plus 2.0 Array)   213219_at (Human Genome U133 Plus 2.0 Array)   217687_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000425069
Ensembl peptide - ENSP00000426196
Ensembl peptide - ENSP00000342952
NCBI entrez gene - 108     See in Manteia.
OMIM - 103071
RefSeq - NM_020546
RefSeq - XM_011513942
RefSeq Peptide - NP_065433
swissprot - D6REB8
swissprot - H0YA58
swissprot - Q08462
Ensembl - ENSG00000078295
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adcy2aENSDARG00000058392Danio rerio
 adcy2bENSDARG00000014588Danio rerio
 ADCY2ENSGALG00000013060Gallus gallus
 Adcy2ENSMUSG00000021536Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADCY4 / Q8NFM4 / adenylate cyclase 4ENSG0000012946756
ADCY7 / P51828 / adenylate cyclase 7ENSG0000012128155
ADCY5 / O95622 / adenylate cyclase 5ENSG0000017317538
ADCY6 / O43306 / adenylate cyclase 6ENSG0000017423338
ADCY8 / P40145 / adenylate cyclase 8ENSG0000015589735
ADCY1 / Q08828 / adenylate cyclase 1ENSG0000016474233
ADCY3 / O60266 / adenylate cyclase 3ENSG0000013803133
ADCY9 / O60503 / adenylate cyclase 9ENSG0000016210428


Protein motifs (from Interpro)
Interpro ID Name
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR009398  Adenylate cyclase, conserved domain
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR029787  Nucleotide cyclase
 IPR030672  Adenylate cyclase
 IPR032628  Adenylate cyclase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003091 renal water homeostasis TAS
 biological_processGO:0006171 cAMP biosynthetic process ISS
 biological_processGO:0006182 cGMP biosynthetic process IBA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007190 activation of adenylate cyclase activity TAS
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0019933 cAMP-mediated signaling ISS
 biological_processGO:0034199 activation of protein kinase A activity TAS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0071377 cellular response to glucagon stimulus TAS
 biological_processGO:1904322 cellular response to forskolin ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0008074 guanylate cyclase complex, soluble IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0045121 membrane raft ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISS
 molecular_functionGO:0004016 adenylate cyclase activity ISS
 molecular_functionGO:0004383 guanylate cyclase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008179 adenylate cyclase binding ISS
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA
 molecular_functionGO:0030145 manganese ion binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity ISS


Pathways (from Reactome)
Pathway description
Glucagon signaling in metabolic regulation
PKA activation
PKA activation in glucagon signalling
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
G alpha (s) signalling events
G alpha (i) signalling events
G alpha (z) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog off state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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