ENSG00000155897


Homo sapiens

Features
Gene ID: ENSG00000155897
  
Biological name :ADCY8
  
Synonyms : ADCY8 / adenylate cyclase 8 / P40145
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q24.22
Gene start: 130780301
Gene end: 131042426
  
Corresponding Affymetrix probe sets: 206811_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000286355
Ensembl peptide - ENSP00000428010
Ensembl peptide - ENSP00000367161
NCBI entrez gene - 114     See in Manteia.
OMIM - 103070
RefSeq - XM_005250769
RefSeq - XM_006716501
RefSeq - XM_017013006
RefSeq - XM_017013007
RefSeq - NM_001115
RefSeq Peptide - NP_001106
swissprot - P40145
swissprot - E5RFR2
swissprot - A0A0K0K1K3
swissprot - E7EVL1
Ensembl - ENSG00000155897
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adcy8ENSDARG00000031783Danio rerio
 ADCY8ENSGALG00000030251Gallus gallus
 Adcy8ENSMUSG00000022376Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADCY6 / O43306 / adenylate cyclase 6ENSG0000017423337
ADCY5 / O95622 / adenylate cyclase 5ENSG0000017317536
ADCY1 / Q08828 / adenylate cyclase 1ENSG0000016474232
ADCY2 / Q08462 / adenylate cyclase 2ENSG0000007829531
ADCY4 / Q8NFM4 / adenylate cyclase 4ENSG0000012946730
ADCY3 / O60266 / adenylate cyclase 3ENSG0000013803130
ADCY7 / P51828 / adenylate cyclase 7ENSG0000012128127
ADCY9 / O60503 / adenylate cyclase 9ENSG0000016210425


Protein motifs (from Interpro)
Interpro ID Name
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR009398  Adenylate cyclase, conserved domain
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR029787  Nucleotide cyclase
 IPR030672  Adenylate cyclase
 IPR032628  Adenylate cyclase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003091 renal water homeostasis TAS
 biological_processGO:0006171 cAMP biosynthetic process IEA
 biological_processGO:0006182 cGMP biosynthetic process IBA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007190 activation of adenylate cyclase activity TAS
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007611 learning or memory TAS
 biological_processGO:0007616 long-term memory IEA
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0034199 activation of protein kinase A activity TAS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0071377 cellular response to glucagon stimulus TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008074 guanylate cyclase complex, soluble IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004016 adenylate cyclase activity IEA
 molecular_functionGO:0004383 guanylate cyclase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity TAS
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Glucagon signaling in metabolic regulation
PKA activation
PKA activation in glucagon signalling
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
G alpha (s) signalling events
G alpha (i) signalling events
G alpha (z) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
CREB phosphorylation through the activation of Adenylate Cyclase
Hedgehog off state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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