ENSMUSG00000022376


Mus musculus

Features
Gene ID: ENSMUSG00000022376
  
Biological name :Adcy8
  
Synonyms : Adcy8 / Adenylate cyclase type 8 / P97490
  
Possible biological names infered from orthology : adenylate cyclase 8 / P40145
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D1
Gene start: 64697084
Gene end: 64922296
  
Corresponding Affymetrix probe sets: 10429029 (MoGene1.0st)   1418754_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023007
Ensembl peptide - ENSMUSP00000154029
NCBI entrez gene - 11514     See in Manteia.
MGI - MGI:1341110
RefSeq - XM_006520319
RefSeq - NM_001291903
RefSeq - NM_009623
RefSeq Peptide - NP_033753
RefSeq Peptide - NP_001278832
swissprot - P97490
Ensembl - ENSMUSG00000022376
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adcy8ENSDARG00000031783Danio rerio
 ADCY8ENSGALG00000030251Gallus gallus
 ADCY8ENSG00000155897Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adcy6 / adenylate cyclase 6 / O43306*ENSMUSG0000002299436
Adcy5 / P84309 / Adenylate cyclase type 5 / O95622* / adenylate cyclase 5*ENSMUSG0000002284036
Adcy1 / O88444 / Adenylate cyclase type 1 / Q08828* / adenylate cyclase 1*ENSMUSG0000002043132
Adcy3 / Q8VHH7 / Adenylate cyclase type 3 / O60266* / adenylate cyclase 3*ENSMUSG0000002065430
Adcy2 / adenylate cyclase 2 / Q08462*ENSMUSG0000002153630
Adcy4 / Q91WF3 / Adenylate cyclase type 4 / Q8NFM4* / adenylate cyclase 4*ENSMUSG0000002222029
Adcy7 / P51829 / Adenylate cyclase type 7 / P51828* / adenylate cyclase 7*ENSMUSG0000003165928
Adcy9 / P51830 / Adenylate cyclase type 9 / O60503* / adenylate cyclase 9*ENSMUSG0000000558025


Protein motifs (from Interpro)
Interpro ID Name
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR009398  Adenylate cyclase, conserved domain
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR029787  Nucleotide cyclase
 IPR030672  Adenylate cyclase
 IPR032628  Adenylate cyclase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006171 cAMP biosynthetic process IEA
 biological_processGO:0006182 cGMP biosynthetic process IBA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007616 long-term memory IGI
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008074 guanylate cyclase complex, soluble IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004016 adenylate cyclase activity IEA
 molecular_functionGO:0004383 guanylate cyclase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Glucagon signaling in metabolic regulation
PKA activation
PKA activation in glucagon signalling
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
G alpha (s) signalling events
G alpha (z) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
CREB phosphorylation through the activation of Adenylate Cyclase
Hedgehog off state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Usp14nmf375/Usp14nmf375
Genetic Background: B6;CByJ-Usp14nmf375/J

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Usp14nmf375/Usp14nmf375
Genetic Background: B6;CByJ-Usp14nmf375/J

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Myt1)2Ggu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003963 abnormal corticosterone level "anomalous blood or tissue concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0004000 impaired passive avoidance behavior "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Usp14nmf375/Usp14nmf375
Genetic Background: B6;CByJ-Usp14nmf375/J

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adcy1tm1Drs/Adcy1tm1Drs,Adcy8tm1Ljm/Adcy8tm1Ljm
Genetic Background: involves: 129 * Black Swiss

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Usp14nmf375/Usp14nmf375
Genetic Background: B6;CByJ-Usp14nmf375/J

Allelic Composition: Adcy1tm1Drs/Adcy1tm1Drs,Adcy8tm1Ljm/Adcy8tm1Ljm
Genetic Background: involves: 129 * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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