ENSMUSG00000005580


Mus musculus

Features
Gene ID: ENSMUSG00000005580
  
Biological name :Adcy9
  
Synonyms : Adcy9 / Adenylate cyclase type 9 / P51830
  
Possible biological names infered from orthology : adenylate cyclase 9 / O60503
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A1
Gene start: 4287529
Gene end: 4420498
  
Corresponding Affymetrix probe sets: 10437364 (MoGene1.0st)   1418586_at (Mouse Genome 430 2.0 Array)   1419811_at (Mouse Genome 430 2.0 Array)   1434454_at (Mouse Genome 430 2.0 Array)   1449620_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005719
Ensembl peptide - ENSMUSP00000113421
Ensembl peptide - ENSMUSP00000113498
NCBI entrez gene - 11515     See in Manteia.
MGI - MGI:108450
RefSeq - XM_011245806
RefSeq - NM_001291910
RefSeq - NM_009624
RefSeq - XM_011245805
RefSeq Peptide - NP_033754
RefSeq Peptide - NP_001278839
swissprot - P51830
swissprot - E9Q706
Ensembl - ENSMUSG00000005580
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adcy9ENSDARG00000100869Danio rerio
 CR339059.1ENSDARG00000103847Danio rerio
 ADCY9ENSGALG00000007779Gallus gallus
 ADCY9ENSG00000162104Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adcy4 / Q91WF3 / Adenylate cyclase type 4 / Q8NFM4* / adenylate cyclase 4*ENSMUSG0000002222023
Adcy6 / adenylate cyclase 6 / O43306*ENSMUSG0000002299423
Adcy1 / O88444 / Adenylate cyclase type 1 / Q08828* / adenylate cyclase 1*ENSMUSG0000002043123
Adcy3 / Q8VHH7 / Adenylate cyclase type 3 / O60266* / adenylate cyclase 3*ENSMUSG0000002065423
Adcy8 / P97490 / Adenylate cyclase type 8 / P40145* / adenylate cyclase 8*ENSMUSG0000002237623
Adcy5 / P84309 / Adenylate cyclase type 5 / O95622* / adenylate cyclase 5*ENSMUSG0000002284023
Adcy7 / P51829 / Adenylate cyclase type 7 / P51828* / adenylate cyclase 7*ENSMUSG0000003165922
Adcy2 / adenylate cyclase 2 / Q08462*ENSMUSG0000002153622


Protein motifs (from Interpro)
Interpro ID Name
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR029787  Nucleotide cyclase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006171 cAMP biosynthetic process ISO
 biological_processGO:0006182 cGMP biosynthetic process IBA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway ISO
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0008074 guanylate cyclase complex, soluble IBA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane ISO
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004016 adenylate cyclase activity ISO
 molecular_functionGO:0004383 guanylate cyclase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Glucagon signaling in metabolic regulation
PKA activation
PKA activation in glucagon signalling
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
G alpha (s) signalling events
G alpha (z) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog off state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000497 abnormal small intestine placement "different location or arrangement of the small intestinal tract" [J:40203]
Show

Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0000602 enlarged sinusoidal spaces "larger than normal sized cavities in the liver " [J:23170]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0001015 small superior cervical ganglion "reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:23882]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0003020 decreased circulating chloride level "reduced concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: A830005F24Riktm1.1(KOMP)Mbp/A830005F24Rik+
Genetic Background: C57BL/6N-A830005F24Riktm1.1(KOMP)Mbp/Ucd

 MP:0003826 abnormal Mullerian duct morphology "malformation of the transient embryonic tubes that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0004666 absent stapedial artery "absence of the small artery that passes through the ring of the stapes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0005272 abnormal temporal bone morphology "anomalous structure of the large, irregular bone located at the base and side of the skull; consists of three parts at birth: squamous, tympanic, and petrous" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Dlo/Baxtm1Dlo
Genetic Background: involves: 129P2/OlaHsd

 MP:0009571 abnormal right lung accessory lobe morphology 
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0011683 dual inferior vena cava "presence of two inferior vena cavae, often resulting from the persistence of both supracardinal veins during development; the two structures may be symmetric or asymmetric but typically join together at the renal vein" [MGI:csmith, PMID:10835118]
Show

Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0013840 absent segment of posterior cerebral artery "absence of a portion of one of a pair of blood vessels that supplies oxygenated blood to the posterior aspect of the brain" [UBERON:0001636]
Show

Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0013847 retropleural edema "accumulation of watery or serous fluid in the retropleural space" [MGI:csmith]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0013852 abnormal Mullerian duct topology "aberrant position of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [ISBN:0-683-40008-8]
Show

Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0013876 absent ductus venosus valve "absence of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0013877 abnormal ductus venosus valve morphology "any structural anomaly of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0013971 blood in lymph vessels 
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0013985 abnormal umbilical vein topology "abnormal position of the umbilical vein in relationship to other umbilical cord structures" [MGI:csmith]
Show

Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0014001 abnormal vertebral artery topology "abnormal position of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [MGI:csmith]
Show

Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0014003 additional anastomosis between intracranial vertebral arteries 
Show

Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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