Manteia

ENSMUSG00000022840

Mus musculus

Features

Gene ID:	ENSMUSG00000022840

Biological name :	Adcy5

Synonyms :	Adcy5 / Adenylate cyclase type 5 / P84309

Possible biological names infered from orthology :	adenylate cyclase 5 / O95622

Species:	Mus musculus

Chr. number:	16
Strand:	1
Band:	B3
Gene start:	35154877
Gene end:	35305737

Corresponding Affymetrix probe sets:	10435388 (MoGene1.0st) 1439829_at (Mouse Genome 430 2.0 Array) 1443080_at (Mouse Genome 430 2.0 Array) 1447696_x_at (Mouse Genome 430 2.0 Array) 1455296_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000110563 NCBI entrez gene - 224129 See in Manteia. MGI - MGI:99673 RefSeq - NM_001012765 RefSeq Peptide - NP_001012783 swissprot - P84309 Ensembl - ENSMUSG00000022840

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
adcy5	ENSDARG00000091342	Danio rerio
ADCY5	ENSGALG00000031244	Gallus gallus
ADCY5	ENSG00000173175	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Adcy6 / adenylate cyclase 6 / O43306*	ENSMUSG00000022994	62
Adcy1 / O88444 / Adenylate cyclase type 1 / Q08828* / adenylate cyclase 1*	ENSMUSG00000020431	35
Adcy8 / P97490 / Adenylate cyclase type 8 / P40145* / adenylate cyclase 8*	ENSMUSG00000022376	35
Adcy2 / adenylate cyclase 2 / Q08462*	ENSMUSG00000021536	33
Adcy3 / Q8VHH7 / Adenylate cyclase type 3 / O60266* / adenylate cyclase 3*	ENSMUSG00000020654	31
Adcy7 / P51829 / Adenylate cyclase type 7 / P51828* / adenylate cyclase 7*	ENSMUSG00000031659	31
Adcy4 / Q91WF3 / Adenylate cyclase type 4 / Q8NFM4* / adenylate cyclase 4*	ENSMUSG00000022220	31
Adcy9 / P51830 / Adenylate cyclase type 9 / O60503* / adenylate cyclase 9*	ENSMUSG00000005580	24

Protein motifs (from Interpro)

Interpro ID	Name
IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase
IPR009398	Adenylate cyclase, conserved domain
IPR018297	Adenylyl cyclase class-4/guanylyl cyclase, conserved site
IPR029787	Nucleotide cyclase
IPR030672	Adenylate cyclase
IPR032628	Adenylate cyclase, N-terminal

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001973	adenosine receptor signaling pathway	IGI
biological_process	GO:0006171	cAMP biosynthetic process	TAS
biological_process	GO:0006182	cGMP biosynthetic process	IBA
biological_process	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	IGI
biological_process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	IGI
biological_process	GO:0007204	positive regulation of cytosolic calcium ion concentration	IEA
biological_process	GO:0007626	locomotory behavior	IMP
biological_process	GO:0009190	cyclic nucleotide biosynthetic process	IEA
biological_process	GO:0035556	intracellular signal transduction	IEA
biological_process	GO:0050885	neuromuscular process controlling balance	IMP
biological_process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	IEA
biological_process	GO:1904322	cellular response to forskolin	IEA
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0005929	cilium	IEA
cellular_component	GO:0008074	guanylate cyclase complex, soluble	IBA
cellular_component	GO:0016020	membrane	IDA
cellular_component	GO:0016021	integral component of membrane	ISO
cellular_component	GO:0042995	cell projection	IEA
cellular_component	GO:0045111	intermediate filament cytoskeleton	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004016	adenylate cyclase activity	ISO
molecular_function	GO:0004383	guanylate cyclase activity	IBA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0008179	adenylate cyclase binding	IPI
molecular_function	GO:0016829	lyase activity	IEA
molecular_function	GO:0016849	phosphorus-oxygen lyase activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0046982	protein heterodimerization activity	IPI
molecular_function	GO:0097110	scaffold protein binding	IPI

Pathways (from Reactome)

Pathway description

Glucagon signaling in metabolic regulation

PKA activation

PKA activation in glucagon signalling

Adenylate cyclase activating pathway

Adenylate cyclase inhibitory pathway

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

Adrenaline,noradrenaline inhibits insulin secretion

G alpha (s) signalling events

G alpha (z) signalling events

Vasopressin regulates renal water homeostasis via Aquaporins

Hedgehog off state

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Cdc7^tm1Hmas/Cdc7^tm1Hmas,Trp53^tm2Mok/Trp53^tm2Mok Genetic Background: involves: 129S/Sv * C57BL/6
MP:0001405	impaired coordination	"reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cdc7^tm1Hmas/Cdc7^tm1Hmas,Trp53^tm2Mok/Trp53^tm2Mok Genetic Background: involves: 129S/Sv * C57BL/6
MP:0002757	reduced vertical activity	"lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Cdc7^tm1Hmas/Cdc7^tm1Hmas,Trp53^tm2Mok/Trp53^tm2Mok Genetic Background: involves: 129S/Sv * C57BL/6
MP:0005156	bradykinesia	"decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]	Show Allelic Composition: Cdc7^tm1Hmas/Cdc7^tm1Hmas,Trp53^tm2Mok/Trp53^tm2Mok Genetic Background: involves: 129S/Sv * C57BL/6
MP:0005584	abnormal enzyme/coenzyme activity	"altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cdc7^tm1Hmas/Cdc7^tm1Hmas,Trp53^tm2Mok/Trp53^tm2Mok Genetic Background: involves: 129S/Sv * C57BL/6
MP:0009747	impaired behavioral response to xenobiotic	"decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nf2^tm2.1Gth/Nf2^tm2.1Gth Genetic Background: involves: 129P2/OlaHsd * FVB/N

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr