ENSMUSG00000020431


Mus musculus

Features
Gene ID: ENSMUSG00000020431
  
Biological name :Adcy1
  
Synonyms : Adcy1 / Adenylate cyclase type 1 / O88444
  
Possible biological names infered from orthology : adenylate cyclase 1 / Q08828
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A1
Gene start: 7063489
Gene end: 7178506
  
Corresponding Affymetrix probe sets: 10374202 (MoGene1.0st)   1445359_at (Mouse Genome 430 2.0 Array)   1456487_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020706
NCBI entrez gene - 432530     See in Manteia.
MGI - MGI:99677
RefSeq - NM_009622
RefSeq Peptide - NP_033752
swissprot - O88444
Ensembl - ENSMUSG00000020431
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adcy1aENSDARG00000069026Danio rerio
 adcy1bENSDARG00000088634Danio rerio
 ADCY1ENSGALG00000031170Gallus gallus
 ADCY1ENSG00000164742Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adcy6 / adenylate cyclase 6 / O43306*ENSMUSG0000002299440
Adcy5 / P84309 / Adenylate cyclase type 5 / O95622* / adenylate cyclase 5*ENSMUSG0000002284039
Adcy8 / P97490 / Adenylate cyclase type 8 / P40145* / adenylate cyclase 8*ENSMUSG0000002237636
Adcy4 / Q91WF3 / Adenylate cyclase type 4 / Q8NFM4* / adenylate cyclase 4*ENSMUSG0000002222034
Adcy7 / P51829 / Adenylate cyclase type 7 / P51828* / adenylate cyclase 7*ENSMUSG0000003165934
Adcy2 / adenylate cyclase 2 / Q08462*ENSMUSG0000002153633
Adcy3 / Q8VHH7 / Adenylate cyclase type 3 / O60266* / adenylate cyclase 3*ENSMUSG0000002065432
Adcy9 / P51830 / Adenylate cyclase type 9 / O60503* / adenylate cyclase 9*ENSMUSG0000000558028


Protein motifs (from Interpro)
Interpro ID Name
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR029787  Nucleotide cyclase
 IPR030672  Adenylate cyclase
 IPR032628  Adenylate cyclase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006171 cAMP biosynthetic process TAS
 biological_processGO:0006182 cGMP biosynthetic process IBA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007190 activation of adenylate cyclase activity TAS
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007616 long-term memory IGI
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0010226 response to lithium ion IEA
 biological_processGO:0019933 cAMP-mediated signaling ISS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0071277 cellular response to calcium ion ISS
 biological_processGO:1904322 cellular response to forskolin ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0008074 guanylate cyclase complex, soluble IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004016 adenylate cyclase activity TAS
 molecular_functionGO:0004383 guanylate cyclase activity IBA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Glucagon signaling in metabolic regulation
PKA activation
PKA activation in glucagon signalling
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
G alpha (s) signalling events
G alpha (z) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
CREB phosphorylation through the activation of Adenylate Cyclase
Hedgehog off state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pkp3tm1.1Fvr/Pkp3tm1.1Fvr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

 MP:0000861 disorganized barrel cortex "derangement of the pattern of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [Principles of Neural Science:ISBN 0-8385-8034-3, J:64064]
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Allelic Composition: Ryr3tm1Tno/Ryr3+
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0000862 absent barrels in primary somatosensory cortex "missing pattern of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:64064]
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Allelic Composition: Ryr3tm1Tno/Ryr3+
Genetic Background: involves: 129S4/SvJae * C57BL/6N

Allelic Composition: Adcy1tm1.1Ito/Adcy1tm1.1Ito
Genetic Background: B6.129P2-Adcy1tm1.1Ito

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Usp14nmf375/Usp14nmf375
Genetic Background: B6;CByJ-Usp14nmf375/J

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Usp14nmf375/Usp14nmf375
Genetic Background: B6;CByJ-Usp14nmf375/J

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Usp14nmf375/Usp14nmf375
Genetic Background: B6;CByJ-Usp14nmf375/J

Allelic Composition: Adcy1tm1Ito/Adcy1tm1.1Ito,Tg(Emx1-cre)3Ito/0
Genetic Background: B6.Cg-Adcy1tm1Ito Adcy1tm1.1Ito Tg(Emx1-cre)3Ito

Allelic Composition: Adcy1tm1Ito/Adcy1tm1.1Ito,Emx1tm1(cre)Ito/Emx1+
Genetic Background: B6.129P2-Emx1tm1(cre)Ito Adcy1tm1Ito Adcy1tm1.1Ito

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kat2atm1Nkt/Kat2atm1Nkt,Kat2btm1Nkt/Kat2btm1Nkt
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0001908 abnormal somatosensory cortex function "anomalous activity of the area of the parietal lobe concerned with receiving general sensations" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ryr3tm1Tno/Ryr3+
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pkp3tm1.1Fvr/Pkp3tm1.1Fvr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Kat2atm1Nkt/Kat2atm1Nkt,Kat2btm1Nkt/Kat2btm1Nkt
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Usp14nmf375/Usp14nmf375
Genetic Background: B6;CByJ-Usp14nmf375/J

 MP:0003989 abnormal barrel cortex morphology "malformation of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Adcy1tm1Ito/Adcy1tm1.1Ito,Tg(Emx1-cre)3Ito/0
Genetic Background: B6.Cg-Adcy1tm1Ito Adcy1tm1.1Ito Tg(Emx1-cre)3Ito

Allelic Composition: Adcy1tm1Ito/Adcy1tm1.1Ito,Emx1tm1(cre)Ito/Emx1+
Genetic Background: B6.129P2-Emx1tm1(cre)Ito Adcy1tm1Ito Adcy1tm1.1Ito

 MP:0004000 impaired passive avoidance behavior "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Usp14nmf375/Usp14nmf375
Genetic Background: B6;CByJ-Usp14nmf375/J

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adcy1tm1Ito/Adcy1tm1.1Ito,Tg(Emx1-cre)3Ito/0
Genetic Background: B6.Cg-Adcy1tm1Ito Adcy1tm1.1Ito Tg(Emx1-cre)3Ito

Allelic Composition: Adcy1tm1Ito/Adcy1tm1.1Ito,Emx1tm1(cre)Ito/Emx1+
Genetic Background: B6.129P2-Emx1tm1(cre)Ito Adcy1tm1Ito Adcy1tm1.1Ito

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Usp14nmf375/Usp14nmf375
Genetic Background: B6;CByJ-Usp14nmf375/J

Allelic Composition: Adcy1tm1Drs/Adcy1tm1Drs,Adcy8tm1Ljm/Adcy8tm1Ljm
Genetic Background: involves: 129 * Black Swiss

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Usp14nmf375/Usp14nmf375
Genetic Background: B6;CByJ-Usp14nmf375/J

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Usp14nmf375/Usp14nmf375
Genetic Background: B6;CByJ-Usp14nmf375/J

Allelic Composition: Adcy1tm1Drs/Adcy1tm1Drs,Adcy8tm1Ljm/Adcy8tm1Ljm
Genetic Background: involves: 129 * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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