ENSMUSG00000020654


Mus musculus

Features
Gene ID: ENSMUSG00000020654
  
Biological name :Adcy3
  
Synonyms : Adcy3 / Adenylate cyclase type 3 / Q8VHH7
  
Possible biological names infered from orthology : adenylate cyclase 3 / O60266
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.1
Gene start: 4133103
Gene end: 4213525
  
Corresponding Affymetrix probe sets: 10394258 (MoGene1.0st)   1421959_s_at (Mouse Genome 430 2.0 Array)   1421960_at (Mouse Genome 430 2.0 Array)   1436928_s_at (Mouse Genome 430 2.0 Array)   1436929_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020984
Ensembl peptide - ENSMUSP00000115406
Ensembl peptide - ENSMUSP00000115644
Ensembl peptide - ENSMUSP00000122073
NCBI entrez gene - 104111     See in Manteia.
MGI - MGI:99675
RefSeq - XM_006514935
RefSeq - NM_001159536
RefSeq - NM_001159537
RefSeq - NM_138305
RefSeq - XM_006514932
RefSeq - XM_006514933
RefSeq - XM_006514934
RefSeq Peptide - NP_001153008
RefSeq Peptide - NP_001153009
RefSeq Peptide - NP_612178
swissprot - Q8VHH7
swissprot - B8JK56
Ensembl - ENSMUSG00000020654
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adcy3aENSDARG00000077145Danio rerio
 adcy3bENSDARG00000017437Danio rerio
 ADCY3ENSGALG00000016608Gallus gallus
 ADCY3ENSG00000138031Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adcy5 / P84309 / Adenylate cyclase type 5 / O95622* / adenylate cyclase 5*ENSMUSG0000002284035
Adcy6 / adenylate cyclase 6 / O43306*ENSMUSG0000002299434
Adcy8 / P97490 / Adenylate cyclase type 8 / P40145* / adenylate cyclase 8*ENSMUSG0000002237633
Adcy2 / adenylate cyclase 2 / Q08462*ENSMUSG0000002153631
Adcy7 / P51829 / Adenylate cyclase type 7 / P51828* / adenylate cyclase 7*ENSMUSG0000003165931
Adcy1 / O88444 / Adenylate cyclase type 1 / Q08828* / adenylate cyclase 1*ENSMUSG0000002043131
Adcy4 / Q91WF3 / Adenylate cyclase type 4 / Q8NFM4* / adenylate cyclase 4*ENSMUSG0000002222031
Adcy9 / P51830 / Adenylate cyclase type 9 / O60503* / adenylate cyclase 9*ENSMUSG0000000558027


Protein motifs (from Interpro)
Interpro ID Name
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR029787  Nucleotide cyclase
 IPR030672  Adenylate cyclase
 IPR032628  Adenylate cyclase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006171 cAMP biosynthetic process TAS
 biological_processGO:0006182 cGMP biosynthetic process IBA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IMP
 biological_processGO:0007190 activation of adenylate cyclase activity TAS
 biological_processGO:0007338 single fertilization IMP
 biological_processGO:0007340 acrosome reaction IMP
 biological_processGO:0007608 sensory perception of smell IDA
 biological_processGO:0008355 olfactory learning IMP
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0030317 flagellated sperm motility IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:1904322 cellular response to forskolin IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0008074 guanylate cyclase complex, soluble IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004016 adenylate cyclase activity TAS
 molecular_functionGO:0004383 guanylate cyclase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Glucagon signaling in metabolic regulation
PKA activation
PKA activation in glucagon signalling
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
G alpha (s) signalling events
G alpha (z) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
CREB phosphorylation through the activation of Adenylate Cyclase
Hedgehog off state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Adcy3tm1Drs/Adcy3tm1Drs,Omptm1Mom/Omp+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Adcy3tm1Drs/Adcy3tm1Drs,Olfr160tm4Mom/Olfr160+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Adcy3tm1Drs/Adcy3tm1Drs,Olfr16tm2Mom/Olfr16+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Adcy3Jll/Adcy3+
Genetic Background: C57BL/6J-Adcy3Jll

Allelic Composition: Adcy3Jll/Adcy3+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Adcy3Jll/Adcy3Jll
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Adcy3Jll/Adcy3+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Adcy3tm1.1Dek/Adcy3tm1.1Dek,Adcy6tm1.1Dek/Adcy6tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001983 abnormal olfactory system physiology "abnormal function of the system relating to smell " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcl6tm1.1Mtto/Bcl6tm1.1Mtto,Cd79atm1(cre)Reth/Cd79a+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2

 MP:0001984 abnormal olfaction "change in the ability to smell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Diaph1tm1.1Sna/Diaph1tm1.1Sna,Diaph2tm1.2Sna/Y
Genetic Background: B6N.Cg-Diaph1tm1.1Sna Diahp2tm1.2Sna

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adcy3Jll/Adcy3+
Genetic Background: C57BL/6J-Adcy3Jll

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adcy3Jll/Adcy3+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
Show

Allelic Composition: Adcy3tm1.1Dek/Adcy3tm1.1Dek,Adcy6tm1.1Dek/Adcy6tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0003666 impaired sperm capacitation "anomaly in the change undergone by spermatozoa in the female genital tract that enables them to penetrate and fertilize an egg" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96669]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004512 anosmia "loss of the sense of smell" [mberry:Melissa Berry_Genetic Resources Curator]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004542 impaired acrosome reaction "abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005236 abnormal olfactory nerve morphology "anomalous structure of the first cranial nerve, which conveys the sense of smell" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adcy3tm1Drs/Adcy3tm1Drs,Omptm1Mom/Omp+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Adcy3tm1Drs/Adcy3tm1Drs,Olfr17tm1Mom/Olfr17+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Adcy3tm1Drs/Adcy3tm1Drs,Olfr160tm4Mom/Olfr160+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Adcy3Jll/Adcy3+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adcy3Jll/Adcy3+
Genetic Background: C57BL/6J-Adcy3Jll

Allelic Composition: Adcy3Jll/Adcy3+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adcy3Jll/Adcy3+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0005618 decreased potassium excretion "less than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Adcy3tm1.1Dek/Adcy3tm1.1Dek,Adcy6tm1.1Dek/Adcy6tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Adcy3Jll/Adcy3+
Genetic Background: C57BL/6J-Adcy3Jll

Allelic Composition: Adcy3Jll/Adcy3+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Adcy3Jll/Adcy3Jll
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Adcy3Jll/Adcy3+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adcy3tm1.1Dek/Adcy3tm1.1Dek,Adcy6tm1.1Dek/Adcy6tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0008544 impaired olfaction "reduced ability to detect odors" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smarca4tm1Tich/Smarca4+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129/Sv

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adcy3Jll/Adcy3+
Genetic Background: C57BL/6J-Adcy3Jll

 MP:0009136 decreased brown fat cell size "reduction in the size of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322]
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Allelic Composition: Adcy3Jll/Adcy3+
Genetic Background: C57BL/6J-Adcy3Jll

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adcy3Jll/Adcy3+
Genetic Background: C57BL/6J-Adcy3Jll

Allelic Composition: Adcy3Jll/Adcy3+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Adcy3Jll/Adcy3Jll
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Acvrl1tm1Dgen/Acvrl1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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