ENSG00000138031


Homo sapiens

Features
Gene ID: ENSG00000138031
  
Biological name :ADCY3
  
Synonyms : ADCY3 / adenylate cyclase 3 / O60266
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p23.3
Gene start: 24819169
Gene end: 24919839
  
Corresponding Affymetrix probe sets: 209320_at (Human Genome U133 Plus 2.0 Array)   209321_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000401455
Ensembl peptide - ENSP00000399275
Ensembl peptide - ENSP00000402008
Ensembl peptide - ENSP00000476143
Ensembl peptide - ENSP00000475652
Ensembl peptide - ENSP00000406153
Ensembl peptide - ENSP00000260600
Ensembl peptide - ENSP00000384484
Ensembl peptide - ENSP00000389799
NCBI entrez gene - 109     See in Manteia.
OMIM - 600291
RefSeq - XM_017003193
RefSeq - XM_011532492
RefSeq - XM_011532493
RefSeq - XM_011532494
RefSeq - XM_011532496
RefSeq - XM_017003186
RefSeq - XM_017003187
RefSeq - XM_017003188
RefSeq - XM_017003189
RefSeq - XM_017003190
RefSeq - XM_017003191
RefSeq - XM_017003192
RefSeq - NM_001320613
RefSeq - NM_004036
RefSeq - XM_006711925
RefSeq - XM_011532489
RefSeq - XM_011532490
RefSeq - XM_011532491
RefSeq Peptide - NP_001307542
RefSeq Peptide - NP_004027
swissprot - C9J969
swissprot - H7C1A6
swissprot - H7C1S5
swissprot - U3KQR1
swissprot - A0A0A0MSC1
swissprot - O60266
swissprot - C9JYB5
swissprot - U3KQ91
swissprot - C9JLX3
Ensembl - ENSG00000138031
  
Related genetic diseases (OMIM): 617885 - {Obesity, susceptibility to, BMIQ19}, 617885
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adcy3aENSDARG00000077145Danio rerio
 adcy3bENSDARG00000017437Danio rerio
 ADCY3ENSGALG00000016608Gallus gallus
 Adcy3ENSMUSG00000020654Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADCY5 / O95622 / adenylate cyclase 5ENSG0000017317535
ADCY6 / O43306 / adenylate cyclase 6ENSG0000017423334
ADCY8 / P40145 / adenylate cyclase 8ENSG0000015589733
ADCY1 / Q08828 / adenylate cyclase 1ENSG0000016474231
ADCY7 / P51828 / adenylate cyclase 7ENSG0000012128131
ADCY4 / Q8NFM4 / adenylate cyclase 4ENSG0000012946731
ADCY2 / Q08462 / adenylate cyclase 2ENSG0000007829531
ADCY9 / O60503 / adenylate cyclase 9ENSG0000016210427


Protein motifs (from Interpro)
Interpro ID Name
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR029787  Nucleotide cyclase
 IPR030672  Adenylate cyclase
 IPR032628  Adenylate cyclase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003091 renal water homeostasis TAS
 biological_processGO:0006171 cAMP biosynthetic process IEA
 biological_processGO:0006182 cGMP biosynthetic process IBA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007190 activation of adenylate cyclase activity TAS
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0007340 acrosome reaction IEA
 biological_processGO:0007608 sensory perception of smell IEA
 biological_processGO:0008355 olfactory learning IEA
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0030317 flagellated sperm motility IEA
 biological_processGO:0034199 activation of protein kinase A activity TAS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0071377 cellular response to glucagon stimulus TAS
 biological_processGO:1904322 cellular response to forskolin IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0008074 guanylate cyclase complex, soluble IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004016 adenylate cyclase activity IEA
 molecular_functionGO:0004383 guanylate cyclase activity IBA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Glucagon signaling in metabolic regulation
PKA activation
PKA activation in glucagon signalling
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
G alpha (s) signalling events
G alpha (i) signalling events
G alpha (z) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
CREB phosphorylation through the activation of Adenylate Cyclase
Hedgehog off state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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