ENSG00000129467


Homo sapiens

Features
Gene ID: ENSG00000129467
  
Biological name :ADCY4
  
Synonyms : ADCY4 / adenylate cyclase 4 / Q8NFM4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q12
Gene start: 24318349
Gene end: 24335093
  
Corresponding Affymetrix probe sets: 230800_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000453259
Ensembl peptide - ENSP00000312126
Ensembl peptide - ENSP00000450481
Ensembl peptide - ENSP00000450477
Ensembl peptide - ENSP00000393177
Ensembl peptide - ENSP00000453893
Ensembl peptide - ENSP00000450843
Ensembl peptide - ENSP00000452250
NCBI entrez gene - 196883     See in Manteia.
OMIM - 600292
RefSeq - NM_001198568
RefSeq - NM_139247
RefSeq - NM_001198592
RefSeq Peptide - NP_001185521
RefSeq Peptide - NP_001185497
RefSeq Peptide - NP_640340
swissprot - Q8NFM4
swissprot - G3V258
swissprot - G3V262
swissprot - H0YJ57
swissprot - H0YLM0
swissprot - H0YN72
Ensembl - ENSG00000129467
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Adcy4ENSMUSG00000022220Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADCY2 / Q08462 / adenylate cyclase 2ENSG0000007829557
ADCY7 / P51828 / adenylate cyclase 7ENSG0000012128152
ADCY5 / O95622 / adenylate cyclase 5ENSG0000017317537
ADCY6 / O43306 / adenylate cyclase 6ENSG0000017423337
ADCY1 / Q08828 / adenylate cyclase 1ENSG0000016474235
ADCY8 / P40145 / adenylate cyclase 8ENSG0000015589735
ADCY3 / O60266 / adenylate cyclase 3ENSG0000013803132
ADCY9 / O60503 / adenylate cyclase 9ENSG0000016210429


Protein motifs (from Interpro)
Interpro ID Name
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR009398  Adenylate cyclase, conserved domain
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR029787  Nucleotide cyclase
 IPR030672  Adenylate cyclase
 IPR032628  Adenylate cyclase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003091 renal water homeostasis TAS
 biological_processGO:0006171 cAMP biosynthetic process IEA
 biological_processGO:0006182 cGMP biosynthetic process IBA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007190 activation of adenylate cyclase activity TAS
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0034199 activation of protein kinase A activity TAS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0071377 cellular response to glucagon stimulus TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008074 guanylate cyclase complex, soluble IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004016 adenylate cyclase activity IEA
 molecular_functionGO:0004383 guanylate cyclase activity IBA
 molecular_functionGO:0005080 protein kinase C binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Glucagon signaling in metabolic regulation
PKA activation
PKA activation in glucagon signalling
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
G alpha (s) signalling events
G alpha (i) signalling events
G alpha (z) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog off state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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