ENSMUSG00000031659


Mus musculus

Features
Gene ID: ENSMUSG00000031659
  
Biological name :Adcy7
  
Synonyms : Adcy7 / Adenylate cyclase type 7 / P51829
  
Possible biological names infered from orthology : adenylate cyclase 7 / P51828
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C3
Gene start: 88272403
Gene end: 88329962
  
Corresponding Affymetrix probe sets: 10573747 (MoGene1.0st)   1420970_at (Mouse Genome 430 2.0 Array)   1450065_at (Mouse Genome 430 2.0 Array)   1456307_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129252
Ensembl peptide - ENSMUSP00000132528
Ensembl peptide - ENSMUSP00000148207
Ensembl peptide - ENSMUSP00000096122
Ensembl peptide - ENSMUSP00000130594
NCBI entrez gene - 11513     See in Manteia.
MGI - MGI:102891
RefSeq - XM_011248283
RefSeq - NM_001037723
RefSeq - NM_001037724
RefSeq - NM_001109756
RefSeq - NM_007406
RefSeq - XM_011248277
RefSeq - XM_011248278
RefSeq - XM_011248279
RefSeq - XM_011248280
RefSeq - XM_011248281
RefSeq - XM_011248282
RefSeq - XM_006530580
RefSeq Peptide - NP_001032812
RefSeq Peptide - NP_001032813
RefSeq Peptide - NP_001103226
RefSeq Peptide - NP_031432
swissprot - P51829
swissprot - A0A1B0GT56
Ensembl - ENSMUSG00000031659
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adcy7ENSDARG00000060070Danio rerio
 ADCY7ENSGALG00000003837Gallus gallus
 ADCY7ENSG00000121281Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adcy2 / adenylate cyclase 2 / Q08462*ENSMUSG0000002153652
Adcy4 / Q91WF3 / Adenylate cyclase type 4 / Q8NFM4* / adenylate cyclase 4*ENSMUSG0000002222050
Adcy5 / P84309 / Adenylate cyclase type 5 / O95622* / adenylate cyclase 5*ENSMUSG0000002284036
Adcy6 / adenylate cyclase 6 / O43306*ENSMUSG0000002299436
Adcy1 / O88444 / Adenylate cyclase type 1 / Q08828* / adenylate cyclase 1*ENSMUSG0000002043135
Adcy3 / Q8VHH7 / Adenylate cyclase type 3 / O60266* / adenylate cyclase 3*ENSMUSG0000002065432
Adcy8 / P97490 / Adenylate cyclase type 8 / P40145* / adenylate cyclase 8*ENSMUSG0000002237632
Adcy9 / P51830 / Adenylate cyclase type 9 / O60503* / adenylate cyclase 9*ENSMUSG0000000558027


Protein motifs (from Interpro)
Interpro ID Name
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR009398  Adenylate cyclase, conserved domain
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR029787  Nucleotide cyclase
 IPR030672  Adenylate cyclase
 IPR032628  Adenylate cyclase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006171 cAMP biosynthetic process TAS
 biological_processGO:0006182 cGMP biosynthetic process IBA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007190 activation of adenylate cyclase activity TAS
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0060135 maternal process involved in female pregnancy IEA
 biological_processGO:0071361 cellular response to ethanol ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008074 guanylate cyclase complex, soluble IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004016 adenylate cyclase activity TAS
 molecular_functionGO:0004383 guanylate cyclase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Glucagon signaling in metabolic regulation
PKA activation
PKA activation in glucagon signalling
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
G alpha (s) signalling events
G alpha (z) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog off state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003303 peritoneal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the membrane that lines the abdominal cavity and covers most of the viscera" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Zfp335tm1.1Caw/Zfp335+,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0003360 depression-related behavior 
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Allelic Composition: Krt71Mhdarco13/Krt71+
Genetic Background: C3HeB/FeJ-Krt71Mhdarco13

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Adcy7tm1.1Pcst/Adcy7tm1.1Pcst,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Krt71Mhdarco13/Krt71+
Genetic Background: C3HeB/FeJ-Krt71Mhdarco13

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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