ENSG00000082212


Homo sapiens

Features
Gene ID: ENSG00000082212
  
Biological name :ME2
  
Synonyms : malic enzyme 2 / ME2 / P23368
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: 1
Band: q21.2
Gene start: 50878734
Gene end: 50954257
  
Corresponding Affymetrix probe sets: 209397_at (Human Genome U133 Plus 2.0 Array)   210153_s_at (Human Genome U133 Plus 2.0 Array)   210154_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000372384
Ensembl peptide - ENSP00000491152
Ensembl peptide - ENSP00000492733
Ensembl peptide - ENSP00000492638
Ensembl peptide - ENSP00000492393
Ensembl peptide - ENSP00000492377
Ensembl peptide - ENSP00000492309
Ensembl peptide - ENSP00000492272
Ensembl peptide - ENSP00000492085
Ensembl peptide - ENSP00000492067
Ensembl peptide - ENSP00000491954
Ensembl peptide - ENSP00000491793
Ensembl peptide - ENSP00000491724
Ensembl peptide - ENSP00000491520
Ensembl peptide - ENSP00000321070
NCBI entrez gene - 4200     See in Manteia.
OMIM - 154270
RefSeq - NM_002396
RefSeq - NM_001168335
RefSeq Peptide - NP_001161807
RefSeq Peptide - NP_002387
swissprot - A0A1W2PQY8
swissprot - A0A1W2PQT3
swissprot - A0A1W2PQH4
swissprot - A0A1W2PQH3
swissprot - A0A1W2PQF8
swissprot - A0A1W2PQ37
swissprot - A0A1W2PPY2
swissprot - A0A1W2PPH1
swissprot - A0A1W2PRY9
swissprot - P23368
swissprot - A0A1W2PRS2
swissprot - A0A1W2PRH1
swissprot - A0A1W2PR68
Ensembl - ENSG00000082212
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 me2ENSDARG00000100718Danio rerio
 Me2ENSMUSG00000024556Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ME3 / Q16798 / malic enzyme 3ENSG0000015137654
ME1 / P48163 / malic enzyme 1ENSG0000006583353


Protein motifs (from Interpro)
Interpro ID Name
 IPR001891  Malic oxidoreductase
 IPR012301  Malic enzyme, N-terminal domain
 IPR012302  Malic enzyme, NAD-binding
 IPR015884  Malic enzyme, conserved site
 IPR036291  NAD(P)-binding domain superfamily
 IPR037062  Malic enzyme, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006090 pyruvate metabolic process IBA
 biological_processGO:0006108 malate metabolic process IBA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1902031 regulation of NADP metabolic process IMP
 cellular_componentGO:0005739 mitochondrion IBA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004470 malic enzyme activity IEA
 molecular_functionGO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity IEA
 molecular_functionGO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity IBA
 molecular_functionGO:0008948 oxaloacetate decarboxylase activity IEA
 molecular_functionGO:0009055 electron transfer activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000082212 ME2 / P23368 / malic enzyme 2  / complex






 

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