ENSG00000065833


Homo sapiens

Features
Gene ID: ENSG00000065833
  
Biological name :ME1
  
Synonyms : malic enzyme 1 / ME1 / P48163
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q14.2
Gene start: 83210389
Gene end: 83431071
  
Corresponding Affymetrix probe sets: 204058_at (Human Genome U133 Plus 2.0 Array)   204059_s_at (Human Genome U133 Plus 2.0 Array)   211204_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000358719
NCBI entrez gene - 4199     See in Manteia.
OMIM - 154250
RefSeq - NM_002395
RefSeq - XM_011535836
RefSeq Peptide - NP_002386
swissprot - P48163
Ensembl - ENSG00000065833
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 me1ENSDARG00000053215Danio rerio
 ME1ENSGALG00000015849Gallus gallus
 Me1ENSMUSG00000032418Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ME3 / Q16798 / malic enzyme 3ENSG0000015137670
ME2 / P23368 / malic enzyme 2ENSG0000008221254


Protein motifs (from Interpro)
Interpro ID Name
 IPR001891  Malic oxidoreductase
 IPR012301  Malic enzyme, N-terminal domain
 IPR012302  Malic enzyme, NAD-binding
 IPR015884  Malic enzyme, conserved site
 IPR036291  NAD(P)-binding domain superfamily
 IPR037062  Malic enzyme, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process NAS
 biological_processGO:0006090 pyruvate metabolic process IBA
 biological_processGO:0006108 malate metabolic process IDA
 biological_processGO:0006741 NADP biosynthetic process TAS
 biological_processGO:0009725 response to hormone ISS
 biological_processGO:0009743 response to carbohydrate TAS
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0051262 protein tetramerization IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1902031 regulation of NADP metabolic process IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004470 malic enzyme activity IDA
 molecular_functionGO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity IEA
 molecular_functionGO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity ISS
 molecular_functionGO:0008948 oxaloacetate decarboxylase activity IEA
 molecular_functionGO:0009055 electron transfer activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0030145 manganese ion binding IDA
 molecular_functionGO:0043531 ADP binding TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050661 NADP binding TAS
 molecular_functionGO:0051287 NAD binding TAS


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
Pyruvate metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000065833 ME1 / P48163 / malic enzyme 1  / complex






 

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