ENSG00000151376


Homo sapiens

Features
Gene ID: ENSG00000151376
  
Biological name :ME3
  
Synonyms : malic enzyme 3 / ME3 / Q16798
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q14.2
Gene start: 86441108
Gene end: 86672636
  
Corresponding Affymetrix probe sets: 204663_at (Human Genome U133 Plus 2.0 Array)   231295_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433636
Ensembl peptide - ENSP00000440246
Ensembl peptide - ENSP00000437204
Ensembl peptide - ENSP00000435427
Ensembl peptide - ENSP00000434690
Ensembl peptide - ENSP00000434431
Ensembl peptide - ENSP00000315255
Ensembl peptide - ENSP00000376998
Ensembl peptide - ENSP00000431182
NCBI entrez gene - 10873     See in Manteia.
OMIM - 604626
RefSeq - XM_005273717
RefSeq - XM_017017137
RefSeq - XM_017017136
RefSeq - NM_001014811
RefSeq - NM_001161586
RefSeq - XM_017017138
RefSeq - NM_006680
RefSeq Peptide - NP_001155058
RefSeq Peptide - NP_001014811
RefSeq Peptide - NP_001338863
RefSeq Peptide - NP_006671
swissprot - Q16798
swissprot - Q6TCH8
swissprot - E9PNN2
swissprot - E9PKA0
swissprot - E9PMB9
swissprot - E9PND9
Ensembl - ENSG00000151376
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 me3ENSDARG00000002305Danio rerio
 ME3ENSGALG00000017246Gallus gallus
 Me3ENSMUSG00000030621Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ME1 / P48163 / malic enzyme 1ENSG0000006583367
ME2 / P23368 / malic enzyme 2ENSG0000008221252


Protein motifs (from Interpro)
Interpro ID Name
 IPR001891  Malic oxidoreductase
 IPR012301  Malic enzyme, N-terminal domain
 IPR012302  Malic enzyme, NAD-binding
 IPR015884  Malic enzyme, conserved site
 IPR036291  NAD(P)-binding domain superfamily
 IPR037062  Malic enzyme, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006090 pyruvate metabolic process IDA
 biological_processGO:0006108 malate metabolic process IDA
 biological_processGO:0009060 aerobic respiration TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0072592 oxygen metabolic process TAS
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005759 mitochondrial matrix IEA
 molecular_functionGO:0004470 malic enzyme activity IEA
 molecular_functionGO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity IEA
 molecular_functionGO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity IEA
 molecular_functionGO:0008948 oxaloacetate decarboxylase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048037 cofactor binding TAS
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000151376 ME3 / Q16798 / malic enzyme 3  / complex






 

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