ENSMUSG00000030621


Mus musculus

Features
Gene ID: ENSMUSG00000030621
  
Biological name :Me3
  
Synonyms : Me3 / NADP-dependent malic enzyme, mitochondrial / Q8BMF3
  
Possible biological names infered from orthology : malic enzyme 3 / Q16798
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: D3
Gene start: 89632392
Gene end: 89854359
  
Corresponding Affymetrix probe sets: 10554819 (MoGene1.0st)   1429071_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032856
Ensembl peptide - ENSMUSP00000146505
NCBI entrez gene - 109264     See in Manteia.
MGI - MGI:1916679
RefSeq - XM_006507190
RefSeq - NM_181407
RefSeq - XM_006507189
RefSeq Peptide - NP_852072
swissprot - Q8BMF3
swissprot - A0A140LHQ4
Ensembl - ENSMUSG00000030621
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 me3ENSDARG00000002305Danio rerio
 ME3ENSGALG00000017246Gallus gallus
 ME3ENSG00000151376Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Me1 / P06801 / NADP-dependent malic enzyme / P48163* / malic enzyme 1*ENSMUSG0000003241867
Me2 / Q99KE1 / NAD-dependent malic enzyme, mitochondrial / P23368* / malic enzyme 2*ENSMUSG0000002455651


Protein motifs (from Interpro)
Interpro ID Name
 IPR001891  Malic oxidoreductase
 IPR012301  Malic enzyme, N-terminal domain
 IPR012302  Malic enzyme, NAD-binding
 IPR015884  Malic enzyme, conserved site
 IPR036291  NAD(P)-binding domain superfamily
 IPR037062  Malic enzyme, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006090 pyruvate metabolic process IEA
 biological_processGO:0006108 malate metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 molecular_functionGO:0004470 malic enzyme activity ISO
 molecular_functionGO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity IEA
 molecular_functionGO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity IBA
 molecular_functionGO:0008948 oxaloacetate decarboxylase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Mc1rtm1.1(KOMP)Vlcg/Mc1rtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Mc1rtm1.1(KOMP)Vlcg/Ucd

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mc1rtm1.1(KOMP)Vlcg/Mc1rtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Mc1rtm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030621 Me3 / Q8BMF3 / NADP-dependent malic enzyme, mitochondrial / Q16798* / malic enzyme 3*  / complex






 

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